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Acidifying Agents- Achlorhydria – Acidifying Agents in Pharmaceuticals

What does Achlorhydria mean?

Acidifying agents

Acidifying agents are used in condition where there is absence or insufficient secretion of hydrochloric acid in stomach which leads to disease called Achlorhydria or Hypochlorhydria. Achlorhydria can be treated by various acidifying agents like ammonium chloride, dilute HCl, Calcium chloride etc.

Causes of Achlorhydria:

What causes Achlorhydria?

The cause of achlorhydria in first case may be subtotal gastrectomy, atrophic gastritis, carcinoma, gastric polyp etc while in later case it may be chronic nephritis, tuberculosis, hyperthyroidism, chronic alcoholism, sprue, pellagra etc. The symptoms vary with associated disease but they generally include mild diarrhoea or frequent bowl movement, epigastric pain and sensitivity to spicy food.

The pH of stomach is 1.5 -2 when empty and rises to pH 5-6 when food is ingested. The pH of stomach is so low because of the secretion of HCl. Gastric HCl act by destroying the bacteria in the ingested food and drinks. It softens the fibrous food and promotes the formation of the proteolytic enzyme pepsin. This enzyme is formed from pepsinogen at acidic pH (>6). Pepsin helps in the metabolism of proteins in the ingested food. Therefore lack of HCl in the stomach can cause Achlorhydria.

Types of achlorhydria

Two types of achlorhydria are known:
1) where the gastric secretion is devoid of HCl, even after stimulation with histamine phosphate
2) where gastric secretion is devoid of HCl, but secreted upon stimulation with histamine phosphate.

 

 

 

What is an acidifying agent?

What drugs acidify urine?

Acidifying Agents in Pharmaceuticals

Acetic Acid
Acetic Acid, Glacial
Citric Acid, Anhydrous
Citric Acid Monohydrate
Fumaric Acid
Hydrochloric Acid
Hydrochloric Acid, Diluted
Malic Acid
Nitric Acid
Phosphoric Acid
Phosphoric Acid, Diluted
Propionic Acid
Sulfuric Acid
Tartaric Acid

 

 

 

 

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