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Autotaxin – Lysophosphatidic acid (LPA).

Autotaxin is a lysophospholipase D that occurs in plasma and serum and cleaves lysophosphatidylcholine, thereby forming lysophosphatidic acid (LPA). This enzyme occurs as a 125 kDa protein, attached to intracellular vesicles with a single transmembrane domain, and as a soluble extracellular enzyme generated from the former by proteolytic processing and secretion.


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