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Breast cancer resistance protein (BCRP)

The breast cancer resistance protein (BCRP) belongs to the G-branch of the ABC-transporter family (ABCG2). In contrast to most other ABC-proteins, BCRP consists of only one transmembrane domain (TDM) with one nucleotide binding fold (NBF) at its C-terminus.

Because of this structural characteristic BCRP as well as other ABC-transporters with only one TMD are termed half transporters.

To achieve functional activity these transporters have to form hetero- or homodimers.

BCRP is involved in the multidrug resistance of certain tumors and transports endogenous compounds like cholesterol and steroid hormones.

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