A. Drugs acting directly on cells (Cytotoxic drugs)

1. Alkylating agents Mechlorethamine (Mustine HCl)
Nitrogen mustards Cyclophosphamide, Ifosfamide,
Chlorambucil, Melphalan.
Ethylenimine Thio-TEPA
Alkyl sulfonate Busulfan
Nitrosoureas Carmustine (BCNU),
Lomustine (CCNU),
Triazine Dacarbazine (DTIC)

2. Antimetabolites
Folate antagonist Methotrexate (Mtx)
Purine 6-Mercaptopurine (6-MP),
antagonist 6-Thioguanine (6-TG),
Azathioprine, Fludarabine
Pyrimidine 5-Fluorouracil (5-FU), Cytarabine
antagonist (cytosine arabinoside)

3. Vinca alkaloids

Vincristine (Oncovin), Vinblastine

4. Taxanes

Paclitaxel, Docetaxel

5. Epipodophyllo Etoposide
Toxin

6. Camptothecin Topotecan, Irinotecan
Analogues

7. Antibiotics

Actinomycin D (Dactinomycin)
Doxorubicin, Daunorubicin
(Rubidomycin), Mitoxantrone
Bleomycins, Mitomycin C

8. Miscellaneous

Hydroxyurea, Procarbazine,
L-Asparaginase, Cisplatin,
Carboplatin, Imatinib

B. Drugs altering hormonal milieu

1. Glucocorticoids Prednisolone and others
2. Estrogens Fosfestrol, Ethinylestradiol
3. Selective estrogen Tamoxifen, Toremifene
receptor modulators
4. Selective estrogen Fulvestrant
receptor down regulator
5. Aromatase inhibitors Letrozole, Anastrozole,
Exemestane
6. Antiandrogen Flutamide, Bicalutamide
7. 5-a reductase Finasteride, Dutasteride
inhibitors
8. GnRH analogues Naferelin, Triptorelin
9. Progestins Hydroxyprogesterone
caproate, etc.

Miscellaneous Drugs

Immunosuppressants
1. Calcineurin inhibitors (Specific T-cell inhibitors)
Cyclosporine (Ciclosporin), Tacrolimus
2. Antiproliferative drugs (Cytotoxic drugs)
Azathioprine, Cyclophosphamide, Methotrexate,
Chlorambucil, Mycophenolate mofetil (MMF),
Sirolimus
3. Glucocorticoids
Prednisolone and others
4. Antibodies
Muromonab CD3, Antithymocyte globulin (ATG),
Rho(D) immuneglobulin