Contents of the powerpoint on Theories and mechanisms of dissolution testing include:
OUT LINE
Definitions
Theories of Dissolution
Mechanisms of drug release
Wagner theory
Zero order release
First order release
Hixon -Crowel model
Higuchi model
Peppas model
Weibull model
Conclusion
Definitions:
Dissolution:
Dissolution is defined as a process in which a solid substance solubilizes in a given solvent i.e. mass transfer from solid surface to the liquid phase.
Dissolution rate:
Dissolution rate is defined as the amount of solute dissolved in a given solvent under standard conditions of temperature, pH, solvent composition and constant solid surface area.
It is a dynamic process
The rate of dissolution of drug substance is determined by the rate at which solvent-solute forces of attraction overcome the cohesive forces present in solid
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