Contents of the powerpoint on Bioavailability And First-Pass Metabolism include:
INTRODUCTION
PHARMACOKINETICS
BIOAVAILABILITY
4. FIRST PASS METABOLISM
5. PRIMARY SYSTEMS EFFECT PRESYSTEMIC METABOLISM
6. HEPATIC ENZYMES
7. DRUG INTERACTIONS INVOLVING DRUG METABOLISM
8. EVIDENCES OF FIRST PASS EFFECT
9. LIVER EXTRACTION RATIO
10. RELATIONSHIP BETWEEN ABSOLUTE BIOAVAILABILITY AND LIVER EXTRACTION
11. ESTIMATION OF REDUCEDS BIOAVAILABILITY DUE TO LIVER METABOLISM & VARIABLE BLOOD FLOW
12. HEPATIC EXTRACTION RATIOS
13. RELATIONSHIP BETWEEN BLOOD FLOW, INTRINSIC CLEARANCE AND HEPATIC CLEARANCE
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