Contents of the powerpoint on Ion exchangers used in controlled drug delivery include:
MECHANISM OF ION EXCHANGE
FACTORS AFFECTING ION EXCHANGE
PREPARATION OF DRUG RESINATES
EVALUATION OF DRUG RESINATES
Ion-exchange resins have been studied in pharmaceutical applications since the early 1950s,leading to patenting and commercialisation of some resin based formulations.
Resins have found use as pharmacologically-active ingredients and as pharmaceutical excipients that improve drug stability ,mask the taste of a drug, enhance the dissolution of poorly soluble drugs, or achieve sustained or controlled drug delivery.
Advantageous properties, such as a high capacity for drug loading ,an easily executed loading procedure, good drug-retaining properties, and more uniform drug release makes the ion exchangers, as such, attractive for drug delivery systems.
Ion-exchange materials, such as macroreticular resins, gels, membranes and fibers, contain two components: a water insoluble structural component consisting of a polymer framework, and a functional component consisting of fixed acidic or basic ion-exchange groups.
Ion exchange systems are advantageous for drugs that are highly susceptible to degradation by enzymatic processes, since they offer a protective mechanism by temporarily altering the substrate.
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