Contents of the powerpoint on Vaccine adjuvants include:
MECHANISMS OF ADJUVANT ACTION
PROPERTIES OF IDEAL ADJUVANT
TYPES OF ADJUVANTS
MF59:a oil-in-water emulsion
Microorganism – derived adjuvants
Nucleic acid – based adjuvants
USES OF ADJUVANTS
A vaccine is a biological preparation that improves immunity to a particular disease.
A vaccine may contain one or more of the following
Organisms inactivated by chemical or physical means whilst retaining adequate immunogenic properties;
living organisms that are naturally avirulent or that have been treated to attenuate their virulence whilst retaining adequate immunogenic properties;
antigens extracted from or secreted by the infectious agent ;
antigens produced by chemical synthesis in vitro.
A vaccine adjuvant is a component that potentiates the immune response to an antigen and/or modulates it towards the desired immune response.
In the traditional vaccines impurities or other components of organisms act as adjuvants,
For example diphtheria-tetanus- pertussis (DTP) vaccine contains two potent adjuvants from whole cell pertussis vaccine (LPS and PT), whole cell typhoid and cholera vaccines have potent adjuvants (LPS and cholera toxin).
Therefore, purified, synthetic vaccines require potent adjuvants.
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