Cetrizine COLD act Tablet Syrup || Child Adults Dose || Uses || Side Effects || Structure

Cetirizine comes as a tablet, a chewable tablet, an extended release tablet, and a syrup (liquid) to take by mouth. It is usually taken once a day with or without food.
Cetirizine hydrochloride, is an orally active and selective H1-receptor antagonist. The chemical name is (±) – [2- [4- [ (4-chlorophenyl)phenylmethyl] -1- piperazinyl] ethoxy]acetic acid, dihydrochloride. Cetirizine hydrochloride is a racemic compound with an empirical formula of C21H25ClN2O3•2HCl.

The molecular weight is 461.82

cetrizine kids adult dosage side affects

Cetirizine USES

Seasonal Allergic Rhinitis:

This is indicated for the relief of symptoms associated with seasonal allergic rhinitis due to allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes.

Perennial Allergic Rhinitis:

Cetrizine is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.

Chronic Urticaria:

Cetrizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It
significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.

Citrizine Adult and kids dosages

Tablet

5 mg
10 mg
Tablet, oral-disintegrating

10 mg
Tablet, chewable

5 mg
10 mg
Syrup

5 mg/5 ml
Solution

5 mg/5 ml
Geriatric

5 mg orally once per day, may increase to 10 mg per day maximum, depending on the severity of the symptoms, not to exceed 5 mg per day in patients over 77 years old

Cetrizine side effects

drowsiness
excessive tiredness
dry mouth
stomach pain
diarrhea
vomiting

Cetirizine Mechanism of Actions:

Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. The
antihistaminic activity of cetirizine has been clearly documented in a variety of animal and human models. In vivo and ex vivo animal models have shown negligible anticholinergic and
antiserotonergic activity. In clinical studies, however, dry mouth was more common with cetirizine than with placebo. In vitro receptor binding studies have shown no measurable affinity
for other than H1 receptors. Autoradiographic studies with radiolabeled cetirizine in the rat have shown negligible penetration into the brain. Ex vivo experiments in the mouse have shown that
systemically administered cetirizine does not significantly occupy cerebral H1 receptors.

Cetirizine Pharmacokinetics:

Absorption:

Cetirizine was rapidly absorbed with a time to maximum concentration (Tmax) of approximately 1 hour following oral administration of tablets or syrup in adults. Comparable bioavailability was found between the tablet and syrup dosage forms. When healthy volunteers
were administered multiple doses of cetirizine (10 mg tablets once daily for 10 days), a mean peak plasma concentration (Cmax) of 311 ng/mL was observed. No accumulation was observed.
Cetirizine pharmacokinetics were linear for oral doses ranging from 5 to 60 mg. Food had no effect on the extent of cetirizine exposure (AUC) but Tmax was delayed by 1.7 hours and Cmax
was decreased by 23% in the presence of food.

Distribution:

The mean plasma protein binding of cetirizine is 93%, independent of concentration in the range of 25-1000 ng/mL, which includes the therapeutic plasma levels
observed.

Metabolism:

A mass balance study in 6 healthy male volunteers indicated that 70% of the administered radioactivity was recovered in the urine and 10% in the feces. Approximately 50%
of the radioactivity was identified in the urine as unchanged drug. Most of the rapid increase in peak plasma radioactivity was associated with parent drug, suggesting a low degree of first-pass
metabolism. Cetirizine is metabolized to a limited extent by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity. The enzyme or enzymes responsible for this
metabolism have not been identified.

Elimination:

The mean elimination half-life in 146 healthy volunteers across multiple pharmacokinetic studies was 8.3 hours and the apparent total body clearance for cetirizine was
approximately 53 mL/min.

Interaction Studies
Pharmacokinetic interaction studies with cetirizine in adults were conducted withpseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were
observed. In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. The
disposition of theophylline was not altered by concomitant cetirizine administration.

Trade names of Cetirizine

 

A Cet (10mg)
A Cet (60ml)
A Cold
A Cold Susp.
A -Rest
Aalervin Plus (60 ml)
Aaptol CZ
Aceper
Acet (10mg)
Acit (10mg)
Affycet (10mg)
Aglocet
Aglocet
Aglocet (10mg)
Aglocet (30ml)
Agrocet (10mg)
Agrus NS
Agrus NS
Aiday (10mg)
Airtis (5mg) (Cetirizine)Alcare (10mg)
Alce (10mg)
Alcet (10mg)
Alcet (10mg) (Acron Pharma)
Alcet (10mg) (Acron Pharma)
Alcet (10mg) (Jocund India)
Alcet (10mg) (Pharmatech)
Alcet (Suzikem Drugs) (10mg)
Alcoryl
Alday (10mg)
Alday tab (10mg)
Alego (10mg)
Alerbloc (10mg)
Alerbloc (60ml)
Alergid (10mg)
Alergo (10mg)
Alerid
Alerid
Alerid
Alerid (10mg)Alerid (30ml)
Alerid Cold
Alerid Cold
Alernyl
Alertac (10mg)
Alertac (60ml)
Alertac Paed (5mg)
Alervin (10mg)
Alervin (60ml)
Alervin Plus
Alerzo (10mg)
Alger (5mg)
Alger (60ml)
Algine (10mg)
Alid (10mg)
All Care Plus
Allercet
Allercet
Allercet
Allercet (10mg)
Allercet (60ml)
Allercet P (5mg)
Allerhin (10mg)
Allerhin (60ml)
Allerzine (10mg)
Allicet (10mg)
Allset
Alocet (60ml)
Alquit (10mg)
Alrin Plus
Alvin (10mg)
Alzine Plus
Ambrolite-D (5mg/10mg/5mg/1.5mg/5mL)
Ambrolite-D (5mg/10mg/5mg/1.5mg/5mL)
Amven-C (2.5mg/30mg)
Analar (10mg)
Analer -C
Ancet (10mg)
Anncold
Anoril
Antized (10mg)
Antized (30ml)
Antized Plus
Anzin (10mg)
Ariwa
Arizine (10mg)
Arrest
Arzyt (10mg)
Atcet (10mg)
Atcet MD (10mg)
Atozine (10mg)
Avcet (10mg)
Avil-NU
Avizin (10mg)
Avizin (60ml)
AZ (10mg)
Bancet (10mg)
Bealert (10mg)
Benz AP
Benz -AP
Bio act (10mg)
Bio -Cold
Bioder Plus
Bio-Drug Laboratories Pvt Ltd
Biozin (10mg)
Bocet -BD
Brick
Brodcet
Cetiriz (10mg)
Cetiriz (30ml)
Cetirizine (10mg)
Cetirizine-Di Hcl (10mg)
Cetiz (10mg)
Cetiz (10mg) (safe)
Cetiz (10mg) (vega pharma)
Cetlar (10 mg)
Cetlong
Cetlong
Cetlong (10mg)
Cetlong (50ml)
Cetmac (10mg)
Cetmac (30ml)
Cetmax (10mg)
Cet-Max (10mg)
Cetmex (20mg)
Cetnac (10mg)
Cetnaz (10mg)
Cetnet (10mg)
Cetnyl
Cetoday (10mg)
Cetoday Plus
Ceton – P
Ceton (10mg)
Ceton (30ml)
Cetos (10mg)
Cetoz (10mg)
Cetpine (30ml)
Cet-Q (10mg)
Cetra
Cetra (10mg)
Cetracare MD (10mg)
Cetract (10mg)
Cetrad (30ml)
Cetrahist (30ml)
Cetram (10mg)
Cetramac (10mg)
Cetree (10mg)
Cetrezol (10mg)
Cetrezol (5mg)
Cetrezol (60ml)
Cetrezol-D
Cetrezol-D Forte
Cetri (10mg)
Cetri -Plus
Cetricent-DT (10mg)
Cetrich (10mg)
Cetricon (10mg)
Cetrid (10mg)
Cetrid OD (10mg)
Cetridoc (10mg)
Cetrid-OD
Cetriken (10mg)
Cetril (10mg)
Cetril (30ml)
Cetrila (10mg)
Cetrila (60ml)
Cetrila Plus
Cetrila Plus (50 ml)
Cetril-DT (10mg)
Cetrilin (10mg)
Cetrilin (30ml)
Cetrilin (5mg)
Cetrimin (10mg)
Cetrimol (10mg)
Cetrimol P
Cetrimol Plus
Cetrina-MD (10mg)
Cetrine
Cetrine
Cetrine (10mg)
Cetrine (60ml)
Cetrino (10mg)
Cetrisan (10mg)
Cetrish (10mg)
Cetrison (10mg)
Cetrison (60ml)
Cetrisyn (10mg)
Cetritab (10mg)
Cetritop (10mg)
Cetriwal (10mg)
Cetriwin (10mg)
Cetrix
Cetriz (10mg)
Cetrizet (10mg)
Cetrizet (5mg)
Cetrizine (10mg)
Cetrizine (10mg) (Low Cost)
Cetroffin (10mg)
Cetrose (10mg)
Cetscal (10mg)
Cettop (10mg)
Cetup (10mg) (UPS Healthcare)
Ceture-DT (10mg)
Cetven DT (10mg)
Cetven-DT
Cetvil (10mg)
Cetvil (60ml)
Cet-Z (10mg)
Cetzen (10mg)
Cetzest
Cetzest
Cetzid-DT (10mg)
Cetzikan (10mg)
Cetzin (30ml)
Cetzine
Cetzine
Cetzine
Cetzine (10mg)
Cetzine (60ml)
Cetzy (10mg)
Cez
Cez (10mg)
Cezcold
Cezen (10mg)
Cezor (10mg)
Cheston Cold
Cheston Cold (Susp.)
Cinzim
Cistin (10mg)
Cistin (60ml)
Citerid (10mg)
CITI (10mg)
Citiz (10mg)
Citizen DT (10mg)
Citmol -D
Citol (60ml)
Citol DT (10mg)
Citol Plus
Citraclor (10mg)
Citrazan (10mg)
Citri A (10mg)
Citrimin (10mg)
Citrimin (30ml)
Citrimin D
Citrimin D (50 ml)
Citriz (10mg)
Citrizine (10mg)
Cizeb (10mg)
Claritec (10mg)
Cofstop Z
Cold Best
Cold Releive
Cold Relief
Coldace CT
Coldar +
Coldar + (50 ml)
Coldariv
Coldariv – All
Colday Plus
Colday Plus (60 ml)
Coldec (5mg/500mg/10mg/5mg)
Coldeon Plus
Colder + (50 ml)
Coldmed Plus
Coldrest
Coldrid
Coldstil
Coldtil
Coldwar Tab
Coldy
Combit
Confree
Cope (10mg)
Cor-4
Coriz
Corycet
Coryza – CT
Coszin (10mg)
Coszin (30ml)
CPS – 30
Crab (10mg)
CT (10mg)
CT Cold
CTZ (10mg)
Cypzine (10mg)
CZ 3 (10mg)
CZ 3 (60ml)
Cz Cold
CZ-3
CZ-3
D – CD
D – Ice
D Cet (10mg)
D Quill
Daily (10mg)
Decet -BD
Decet -BD (100 ml)
Decet -BD (200 ml)
Decet -OD
Decocet Plus
Dexphen
Dextur
Dezist
Dio 1 (10mg)
Disnee tablets
Dnip
Dofcet (10mg)
Doriz (10mg)
Drinzine
Drykof
E Cet MD (10mg)
Ecitra (10mg)
Effmin – CZ
Ekon (30ml)
Ekon DT (10mg)
Ekon DT (5mg)
Elart (10mg)
Elcet (10mg)
Elcold
Elgnil
Elgnil (10mg)
Elgnil cold
Eltrazin (10mg)
Eltrazin (10mg)
Eltrizin (10mg)
ELU
Embargo (10mg)
Encet – D Plus
Encet (10mg)
Encold-P Tablet (5mg/325mg/5mg/30mg)
Endocard India Pvt.Ltd
Enecet (30ml)
Enecet -P
Enocet (10mg)
Ephiros
Ephiros
Esnopil
Esnopil Syrup
Etric DT (10mg)
Etrizin (10mg)
Excet (10mg)
Excet (60ml)
Eze DT (10mg)
Ezi
Fastcet (10mg)
Fastcet (30ml)
Fazine (5mg)
Fazine DT (10mg)
Fedrine 555
Fila-Cet
Flamoset (60ml)
Flomicet (10mg)
Floramin (10mg)
Flu 4XN
Fluban
Flugo Plus
Fomicet (10mg)
Formicet (10mg)
Fricold
Fulday (10mg)
Glycold
Grecet (10mg)
Gripcold -Plus
GRS Cet (10mg)
Haricold (100 ml)
Haricold (60 ml)
Hicet
Hicet (10mg)
Hicet (30ml)
Hicet DT (10mg) (Flora)
Hicet-DC (10mg/10mg)
Hiikold CZ
Hisdin CT (10mg)
Hisnofil
Hisnofil (10mg)
Hist OD (10mg)
Histacet (10mg)
Histacet -DA
Histacid (10mg)
Histanit (50ml)
Histazin (10mg)
Histodan Z
Hycet (10mg)
Hydrozet
Ifycet – P2
Ifycet DT (10mg)
Ifycet P
Illah (10mg)
IN Cold
Inalam (10mg)
Incetin (10mg)
Incetin (60ml)
Incez
Incez
Incez (60ml)
Incez DT (10mg)
Incid L (10mg)
Incid L (60ml)
Incold Syrup
Indikof -A
Intazin (10mg)
Intazin (30ml)
Intazin (5mg)
Isorid
Isorid
Jecet (10mg)
Jocet (10mg)
Jolly
Jpee (10mg)
Jyocet (10mg)
Jyocet -P
Kap
Kazicold
Kidcet
Kidcet (60ml)
Kidcold Z
Kofcet DT (10mg)
Kofrid
Kofrid D (60 ml)
Kofrid D Syr (100ml)
Kold Clear
Kold Time
Kolder Plus
Konokold
L Cid (10mg)
L R G (10mg)
Lacold
Lancizin (10mg)
Lancizin (60ml)
Lecet (10mg)
Lemohist C
Lergi (10mg)
Leucold
Lexicet (10mg)
Lgnil (30ml)
Lifcet (10mg)
Lifcet Cold
Lifcet Cold (60 ml)
Lynacold
Lynacold (60 ml)
M Cet (10mg)
M Cet (30ml)
M Cit DT (10mg)
Marcold Tab
Mastifen-C
Mcet (10mg)
Mcet (30ml)
M-CIT
Merihist
Metacet -Cold
Metacold
Metriz (10mg)
Morazin (10mg)
Morazin (60ml)
Moredrill
MucoRespules-CZ (30mg/2.5mg/5mL)
Myzin (10mg)
N Cet Cold
N Zin (10mg)
N Zin (30ml)
Nacet (10mg)
Nacold
Nam Cold (60 ml)
Nam Cold Paed DPS (125mg/15mg/2mg)
Nam Cold paed drops
Nam Cold Syr
Nam Cold Z
Nancold
Natcold Plus
Nbcet (10mg)
Nemeriv – CP
Neusonil (10mg)
Nimucet Cold
Nine Cold (325mg/10mg/5mg/30mg/100mg)
No Aller (10mg)
Noalzy (10mg)
Noalzy Plus
Noco
Noco Syp
Nucod -PP
Nymopt Cold
Ocet (10mg)
Ocitiriz (10mg)
Odacet (10mg)
Odacet (30ml)
Odacet (60ml)
Odiday (60ml)
Odiday DT (10mg)
Okacet (30ml)
Okacet cold
Olcet (10mg)
Olcit (10mg)
Onacold SF
Onacold Syrup
Oncet (10mg)
Oncet -CF
Oneday (10mg)
Onrhin
Opner -Fast
Opticet (10mg)
Oricet
Osalka (100ml)
Oshzin (10mg)
P -Cold
P -Dex Cold
Pace (Bewell)
Pamagin C
Pamagin C tab
Pancet (10mg)
Paracet
Paracet (60 ml)
Paracet DT (10mg)
Paracold Susp
Parcet
Parcet PP
Plus-War
Precold
Prenoc-Cold
Pseudosit
C Day (10mg)
C -Knot
C T Cold
C Tec (10mg)
Carcet FC
Carcet Forte
CCF
CCFS
Ce-10 (10mg)
Cecold
Cedo Plus
Ceetive PlusCefid (10mg)
Cepar Cold
Ceriz (10mg)
Ceriz (30ml)
Cerizine FT (5mg)
Certen (10mg
Certen D
Certiwon
Certiwon (10mg)
Cet (10mg)
CET (10mg) (libra)
Cet CCF
Cet PLUS
Cetafed
Cetag (10mg)
Cetall (10mg)
Cetanj DP

 

 

 

 

Cold tablet names in Telugu

Cetirizine is indicated for the relief of nasal and ocular symptoms of seasonal and perennial allergic rhinitis.
– Cetirizine is indicated for the relief of symptoms of chronic idiopathic urticaria.

Posology and method of administration
Children aged from 6 to 12 years: 5mg twice daily (a half tablet twice daily).
Adults and adolescents over 12 years of age: 10mg once daily (1 tablet)
The tablets need to be swallowed with a glass of liquid.

Cetrizine Overdose

Symptoms
Symptoms observed after an overdose of cetirizine are mainly associated with CNS effects or with effects that could suggest an anticholinergic effect. Adverse events
reported after an intake of at least 5 times the recommended daily dose are: confusion, diarrhoea, dizziness, fatigue, headache, malaise, mydriasis, pruritus, restlessness,
sedation, somnolence, stupor, tachycardia, tremor, and urinary retention.
Management
There is no known specific antidote to cetirizine. Should overdose occur symptomatic or supportive treatment is recommended. Gastric lavage should be considered
following ingestion of a short occurrence. Alternatively consider activated charcoal.
Cetirizine is not effectively removed by dialysis.

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