Cetirizine comes as a tablet, a chewable tablet, an extended release tablet, and a syrup (liquid) to take by mouth. It is usually taken once a day with or without food.
Cetirizine hydrochloride, is an orally active and selective H1-receptor antagonist. The chemical name is (±) – [2- [4- [ (4-chlorophenyl)phenylmethyl] -1- piperazinyl] ethoxy]acetic acid, dihydrochloride. Cetirizine hydrochloride is a racemic compound with an empirical formula of C21H25ClN2O3•2HCl.
The molecular weight is 461.82
Cetirizine USES
Seasonal Allergic Rhinitis:
This is indicated for the relief of symptoms associated with seasonal allergic rhinitis due to allergens such as ragweed, grass and tree pollens in adults and children 2 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, nasal pruritus, ocular pruritus, tearing, and redness of the eyes.
Perennial Allergic Rhinitis:
Cetrizine is indicated for the relief of symptoms associated with perennial allergic rhinitis due to allergens such as dust mites, animal dander and molds in adults and children 6 months of age and older. Symptoms treated effectively include sneezing, rhinorrhea, postnasal discharge, nasal pruritus, ocular pruritus, and tearing.
Chronic Urticaria:
Cetrizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 months of age and older. It
significantly reduces the occurrence, severity, and duration of hives and significantly reduces pruritus.
Citrizine Adult and kids dosages
Tablet
5 mg
10 mg
Tablet, oral-disintegrating
10 mg
Tablet, chewable
5 mg
10 mg
Syrup
5 mg/5 ml
Solution
5 mg/5 ml
Geriatric
5 mg orally once per day, may increase to 10 mg per day maximum, depending on the severity of the symptoms, not to exceed 5 mg per day in patients over 77 years old
Cetrizine side effects
drowsiness
excessive tiredness
dry mouth
stomach pain
diarrhea
vomiting
Cetirizine Mechanism of Actions:
Cetirizine, a human metabolite of hydroxyzine, is an antihistamine; its principal effects are mediated via selective inhibition of peripheral H1 receptors. The
antihistaminic activity of cetirizine has been clearly documented in a variety of animal and human models. In vivo and ex vivo animal models have shown negligible anticholinergic and
antiserotonergic activity. In clinical studies, however, dry mouth was more common with cetirizine than with placebo. In vitro receptor binding studies have shown no measurable affinity
for other than H1 receptors. Autoradiographic studies with radiolabeled cetirizine in the rat have shown negligible penetration into the brain. Ex vivo experiments in the mouse have shown that
systemically administered cetirizine does not significantly occupy cerebral H1 receptors.
Cetirizine Pharmacokinetics:
Absorption:
Cetirizine was rapidly absorbed with a time to maximum concentration (Tmax) of approximately 1 hour following oral administration of tablets or syrup in adults. Comparable bioavailability was found between the tablet and syrup dosage forms. When healthy volunteers
were administered multiple doses of cetirizine (10 mg tablets once daily for 10 days), a mean peak plasma concentration (Cmax) of 311 ng/mL was observed. No accumulation was observed.
Cetirizine pharmacokinetics were linear for oral doses ranging from 5 to 60 mg. Food had no effect on the extent of cetirizine exposure (AUC) but Tmax was delayed by 1.7 hours and Cmax
was decreased by 23% in the presence of food.
Distribution:
The mean plasma protein binding of cetirizine is 93%, independent of concentration in the range of 25-1000 ng/mL, which includes the therapeutic plasma levels
observed.
Metabolism:
A mass balance study in 6 healthy male volunteers indicated that 70% of the administered radioactivity was recovered in the urine and 10% in the feces. Approximately 50%
of the radioactivity was identified in the urine as unchanged drug. Most of the rapid increase in peak plasma radioactivity was associated with parent drug, suggesting a low degree of first-pass
metabolism. Cetirizine is metabolized to a limited extent by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity. The enzyme or enzymes responsible for this
metabolism have not been identified.
Elimination:
The mean elimination half-life in 146 healthy volunteers across multiple pharmacokinetic studies was 8.3 hours and the apparent total body clearance for cetirizine was
approximately 53 mL/min.
Interaction Studies
Pharmacokinetic interaction studies with cetirizine in adults were conducted withpseudoephedrine, antipyrine, ketoconazole, erythromycin and azithromycin. No interactions were
observed. In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. The
disposition of theophylline was not altered by concomitant cetirizine administration.
Trade names of Cetirizine
| A Cet (10mg) A Cet (60ml) A Cold A Cold Susp. A -Rest Aalervin Plus (60 ml) Aaptol CZ Aceper Acet (10mg) Acit (10mg) Affycet (10mg) Aglocet Aglocet Aglocet (10mg) Aglocet (30ml) Agrocet (10mg) Agrus NS Agrus NS Aiday (10mg) Airtis (5mg) (Cetirizine)Alcare (10mg) Alce (10mg) Alcet (10mg) Alcet (10mg) (Acron Pharma) Alcet (10mg) (Acron Pharma) Alcet (10mg) (Jocund India) Alcet (10mg) (Pharmatech) Alcet (Suzikem Drugs) (10mg) Alcoryl Alday (10mg) Alday tab (10mg) Alego (10mg) Alerbloc (10mg) Alerbloc (60ml) Alergid (10mg) Alergo (10mg) Alerid Alerid Alerid Alerid (10mg)Alerid (30ml) Alerid Cold Alerid Cold Alernyl Alertac (10mg) Alertac (60ml) Alertac Paed (5mg) Alervin (10mg) Alervin (60ml) Alervin Plus Alerzo (10mg) Alger (5mg) Alger (60ml) Algine (10mg) Alid (10mg) All Care Plus Allercet Allercet Allercet Allercet (10mg) Allercet (60ml) Allercet P (5mg) Allerhin (10mg) Allerhin (60ml) Allerzine (10mg) Allicet (10mg) Allset Alocet (60ml) Alquit (10mg) Alrin Plus Alvin (10mg) Alzine Plus Ambrolite-D (5mg/10mg/5mg/1.5mg/5mL) Ambrolite-D (5mg/10mg/5mg/1.5mg/5mL) Amven-C (2.5mg/30mg) Analar (10mg) Analer -C Ancet (10mg) Anncold Anoril Antized (10mg) Antized (30ml) Antized Plus Anzin (10mg) Ariwa Arizine (10mg) Arrest Arzyt (10mg) Atcet (10mg) Atcet MD (10mg) Atozine (10mg) Avcet (10mg) Avil-NU Avizin (10mg) Avizin (60ml) AZ (10mg) Bancet (10mg) Bealert (10mg) Benz AP Benz -AP Bio act (10mg) Bio -Cold Bioder Plus Bio-Drug Laboratories Pvt Ltd Biozin (10mg) Bocet -BD Brick Brodcet |
Cetiriz (10mg) Cetiriz (30ml) Cetirizine (10mg) Cetirizine-Di Hcl (10mg) Cetiz (10mg) Cetiz (10mg) (safe) Cetiz (10mg) (vega pharma) Cetlar (10 mg) Cetlong Cetlong Cetlong (10mg) Cetlong (50ml) Cetmac (10mg) Cetmac (30ml) Cetmax (10mg) Cet-Max (10mg) Cetmex (20mg) Cetnac (10mg) Cetnaz (10mg) Cetnet (10mg) Cetnyl Cetoday (10mg) Cetoday Plus Ceton – P Ceton (10mg) Ceton (30ml) Cetos (10mg) Cetoz (10mg) Cetpine (30ml) Cet-Q (10mg) Cetra Cetra (10mg) Cetracare MD (10mg) Cetract (10mg) Cetrad (30ml) Cetrahist (30ml) Cetram (10mg) Cetramac (10mg) Cetree (10mg) Cetrezol (10mg) Cetrezol (5mg) Cetrezol (60ml) Cetrezol-D Cetrezol-D Forte Cetri (10mg) Cetri -Plus Cetricent-DT (10mg) Cetrich (10mg) Cetricon (10mg) Cetrid (10mg) Cetrid OD (10mg) Cetridoc (10mg) Cetrid-OD Cetriken (10mg) Cetril (10mg) Cetril (30ml) Cetrila (10mg) Cetrila (60ml) Cetrila Plus Cetrila Plus (50 ml) Cetril-DT (10mg) Cetrilin (10mg) Cetrilin (30ml) Cetrilin (5mg) Cetrimin (10mg) Cetrimol (10mg) Cetrimol P Cetrimol Plus Cetrina-MD (10mg) Cetrine Cetrine Cetrine (10mg) Cetrine (60ml) Cetrino (10mg) Cetrisan (10mg) Cetrish (10mg) Cetrison (10mg) Cetrison (60ml) Cetrisyn (10mg) Cetritab (10mg) Cetritop (10mg) Cetriwal (10mg) Cetriwin (10mg) Cetrix Cetriz (10mg) Cetrizet (10mg) Cetrizet (5mg) Cetrizine (10mg) Cetrizine (10mg) (Low Cost) Cetroffin (10mg) Cetrose (10mg) Cetscal (10mg) Cettop (10mg) Cetup (10mg) (UPS Healthcare) Ceture-DT (10mg) Cetven DT (10mg) Cetven-DT Cetvil (10mg) Cetvil (60ml) Cet-Z (10mg) Cetzen (10mg) Cetzest Cetzest Cetzid-DT (10mg) Cetzikan (10mg) Cetzin (30ml) Cetzine Cetzine Cetzine Cetzine (10mg) Cetzine (60ml) Cetzy (10mg) Cez Cez (10mg) Cezcold Cezen (10mg) Cezor (10mg) Cheston Cold Cheston Cold (Susp.) Cinzim Cistin (10mg) Cistin (60ml) Citerid (10mg) CITI (10mg) Citiz (10mg) Citizen DT (10mg) Citmol -D Citol (60ml) Citol DT (10mg) Citol Plus Citraclor (10mg) Citrazan (10mg) Citri A (10mg) Citrimin (10mg) Citrimin (30ml) Citrimin D Citrimin D (50 ml) Citriz (10mg) Citrizine (10mg) Cizeb (10mg) Claritec (10mg) Cofstop Z Cold Best Cold Releive Cold Relief Coldace CT Coldar + Coldar + (50 ml) Coldariv Coldariv – All Colday Plus Colday Plus (60 ml) Coldec (5mg/500mg/10mg/5mg) Coldeon Plus Colder + (50 ml) Coldmed Plus Coldrest Coldrid Coldstil Coldtil Coldwar Tab Coldy Combit Confree Cope (10mg) Cor-4 Coriz Corycet Coryza – CT Coszin (10mg) Coszin (30ml) CPS – 30 Crab (10mg) CT (10mg) CT Cold CTZ (10mg) Cypzine (10mg) CZ 3 (10mg) CZ 3 (60ml) Cz Cold CZ-3 CZ-3 |
D – CD D – Ice D Cet (10mg) D Quill Daily (10mg) Decet -BD Decet -BD (100 ml) Decet -BD (200 ml) Decet -OD Decocet Plus Dexphen Dextur Dezist Dio 1 (10mg) Disnee tablets Dnip Dofcet (10mg) Doriz (10mg) Drinzine Drykof E Cet MD (10mg) Ecitra (10mg) Effmin – CZ Ekon (30ml) Ekon DT (10mg) Ekon DT (5mg) Elart (10mg) Elcet (10mg) Elcold Elgnil Elgnil (10mg) Elgnil cold Eltrazin (10mg) Eltrazin (10mg) Eltrizin (10mg) ELU Embargo (10mg) Encet – D Plus Encet (10mg) Encold-P Tablet (5mg/325mg/5mg/30mg) Endocard India Pvt.Ltd Enecet (30ml) Enecet -P Enocet (10mg) Ephiros Ephiros Esnopil Esnopil Syrup Etric DT (10mg) Etrizin (10mg) Excet (10mg) Excet (60ml) Eze DT (10mg) Ezi Fastcet (10mg) Fastcet (30ml) Fazine (5mg) Fazine DT (10mg) Fedrine 555 Fila-Cet Flamoset (60ml) Flomicet (10mg) Floramin (10mg) Flu 4XN Fluban Flugo Plus Fomicet (10mg) Formicet (10mg) Fricold Fulday (10mg) Glycold Grecet (10mg) Gripcold -Plus GRS Cet (10mg) Haricold (100 ml) Haricold (60 ml) Hicet Hicet (10mg) Hicet (30ml) Hicet DT (10mg) (Flora) Hicet-DC (10mg/10mg) Hiikold CZ Hisdin CT (10mg) Hisnofil Hisnofil (10mg) Hist OD (10mg) Histacet (10mg) Histacet -DA Histacid (10mg) Histanit (50ml) Histazin (10mg) Histodan Z Hycet (10mg) Hydrozet Ifycet – P2 Ifycet DT (10mg) Ifycet P Illah (10mg) IN Cold Inalam (10mg) Incetin (10mg) Incetin (60ml) Incez Incez Incez (60ml) Incez DT (10mg) Incid L (10mg) Incid L (60ml) Incold Syrup Indikof -A Intazin (10mg) Intazin (30ml) Intazin (5mg) Isorid Isorid Jecet (10mg) Jocet (10mg) Jolly Jpee (10mg) Jyocet (10mg) Jyocet -P Kap Kazicold Kidcet Kidcet (60ml) Kidcold Z Kofcet DT (10mg) Kofrid Kofrid D (60 ml) Kofrid D Syr (100ml) Kold Clear Kold Time Kolder Plus Konokold |
L Cid (10mg) L R G (10mg) Lacold Lancizin (10mg) Lancizin (60ml) Lecet (10mg) Lemohist C Lergi (10mg) Leucold Lexicet (10mg) Lgnil (30ml) Lifcet (10mg) Lifcet Cold Lifcet Cold (60 ml) Lynacold Lynacold (60 ml) M Cet (10mg) M Cet (30ml) M Cit DT (10mg) Marcold Tab Mastifen-C Mcet (10mg) Mcet (30ml) M-CIT Merihist Metacet -Cold Metacold Metriz (10mg) Morazin (10mg) Morazin (60ml) Moredrill MucoRespules-CZ (30mg/2.5mg/5mL) Myzin (10mg) N Cet Cold N Zin (10mg) N Zin (30ml) Nacet (10mg) Nacold Nam Cold (60 ml) Nam Cold Paed DPS (125mg/15mg/2mg) Nam Cold paed drops Nam Cold Syr Nam Cold Z Nancold Natcold Plus Nbcet (10mg) Nemeriv – CP Neusonil (10mg) Nimucet Cold Nine Cold (325mg/10mg/5mg/30mg/100mg) No Aller (10mg) Noalzy (10mg) Noalzy Plus Noco Noco Syp Nucod -PP Nymopt Cold Ocet (10mg) Ocitiriz (10mg) Odacet (10mg) Odacet (30ml) Odacet (60ml) Odiday (60ml) Odiday DT (10mg) Okacet (30ml) Okacet cold Olcet (10mg) Olcit (10mg) Onacold SF Onacold Syrup Oncet (10mg) Oncet -CF Oneday (10mg) Onrhin Opner -Fast Opticet (10mg) Oricet Osalka (100ml) Oshzin (10mg) P -Cold P -Dex Cold Pace (Bewell) Pamagin C Pamagin C tab Pancet (10mg) Paracet Paracet (60 ml) Paracet DT (10mg) Paracold Susp Parcet Parcet PP Plus-War Precold Prenoc-Cold Pseudosit |
C Day (10mg) C -Knot C T Cold C Tec (10mg) Carcet FC Carcet Forte CCF CCFS Ce-10 (10mg) Cecold Cedo Plus Ceetive PlusCefid (10mg) Cepar Cold Ceriz (10mg) Ceriz (30ml) Cerizine FT (5mg) Certen (10mg Certen D Certiwon Certiwon (10mg) Cet (10mg) CET (10mg) (libra) Cet CCF Cet PLUS Cetafed Cetag (10mg) Cetall (10mg) Cetanj DP |
Cold tablet names in Telugu
Cetirizine is indicated for the relief of nasal and ocular symptoms of seasonal and perennial allergic rhinitis.
– Cetirizine is indicated for the relief of symptoms of chronic idiopathic urticaria.
Posology and method of administration
Children aged from 6 to 12 years: 5mg twice daily (a half tablet twice daily).
Adults and adolescents over 12 years of age: 10mg once daily (1 tablet)
The tablets need to be swallowed with a glass of liquid.
Cetrizine Overdose
Symptoms
Symptoms observed after an overdose of cetirizine are mainly associated with CNS effects or with effects that could suggest an anticholinergic effect. Adverse events
reported after an intake of at least 5 times the recommended daily dose are: confusion, diarrhoea, dizziness, fatigue, headache, malaise, mydriasis, pruritus, restlessness,
sedation, somnolence, stupor, tachycardia, tremor, and urinary retention.
Management
There is no known specific antidote to cetirizine. Should overdose occur symptomatic or supportive treatment is recommended. Gastric lavage should be considered
following ingestion of a short occurrence. Alternatively consider activated charcoal.
Cetirizine is not effectively removed by dialysis.