Resources

Contents of the powerpoint on Clinical pharmacokinetics in pregnancy and lactation include:
CONTENTS
Introduction
Alterations in pharmacokinetic parameters
Index of fetal drug exposure
Compartment characterisation
Teratogens
Drug transfer
Pharmacokinetics of
Antiepileptics
Antidepressants
Antiinfectives
References

Pharmacokinetics deals with the description of concentration changes of drugs in the body as a function of time.
In pregnancy and labour the body becomes a complex physiological unit which consists of mother, placenta and fetus.

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Contents of the powerpoint on Bone marrow targeting and targeting to lysosomal diseases include:
CONTENTS

Introduction
Physiology of bone marrow
Bone marrow targets for drug delivery
Colloidal carriers for bone marrow targeting
Nanospheres/nanoparticles
Liposomes
Lysosomal storage diseases
Targeting exogenous enzymes
Conclusion
References

Even biodistribution of pharmaceuticals throughout the body;

The lack of drug specific affinity toward a pathological site;

The necessity of a large total dose of a drug;

Non-specific toxicity and other adverse side-effects.

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Contents of the powerpoint on Aptamers and anti sense agents include:
INTRODUCTION

ANTISENSE AGENTS

DEFINITION
MECHANISM
ADVANTAGES
CELLULAR ACTIVITY
CELLULAR UPTAKE
CLINICAL TRIAL SUBSTANCES

APTAMERS

DEVELOPMENT
PROPERTIES
ADVANTAGES AND DISADVANTAGES
APPLICATIONS

CONCLUSION

REFERENCES

The term ‘Antisense Therapeutics’ or ‘Antisense Technology’ encompasses several types of nucleic acids that have the ability to modulate gene expression. The most common types of nucleic acids included in this term are antisense oligonucleotides (ODNs), ribozymes (RNA enzymes) and more recently, DNAzymes (DNA enzymes).

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Contents of the powerpoint on Volume Of Distribution include:
Objective
Definition
Protein binding of drugs
Tissue binding of drugs
Factors affecting volume of distribution
Steady state volume of distribution
Relationship between clearance & VD & t1/2
Significance
Conclusion
References

To understand and describe the processes by which drugs are distributed throughout the body

To differentiate between apparent volume of distribution & true physiological volume

To understand the effect of protein and tissue binding on volume of drug distribution.

The volume of distribution (VD) , also known as apparent volume of distribution, is a pharmacological term used to quantify the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing.

It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration.

The volume of distribution is a hypothetical volume of fluid into which a drug is distributed, it’s a useful in predicting amount of drug in the body.

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Contents of the powerpoint on Validation Of Raw Materials include:
INTRODUCTION TO VALIDATION
DEFINITION OF VALIDATION
QUALITY ATTRIBUTES
WHY TO VALIDATE
WHEN TO VALIDATE
DEFINITION OF RAW MATERIAL
STEPS INVOLVED IN RAW MATERIAL VALIDATION
CONCLUSION
REFERENCES

Validation is the scientific study of a system
To prove that the facility/system/equipment/method is consistently doing what it is supposed to do (i.e., that the process is under control).

We want to make decisions based on good science and not hunches and assumptions!

To determine the process variables and acceptable limits for these variables, and to set-up appropriate in-process controls.

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Contents of the powerpoint on Types Of Tablets And Their Charecteristics include:
Introduction
Classification of tablets
Characteristics of tablets
Conclusion
References

Tablet is defined as a compressed solid dosage form containing medicaments with or without excipients.

According to the Indian Pharmacopoeia Pharmaceutical tablets are solid, flat or biconvex dishes, unit dosage form, prepared by compressing a drugs or a mixture of drugs, with or without diluents.

They vary in shape and differ greatly in size and weight, depending on amount of medicinal substances and the intended mode of administration.

It is the most popular dosage form and 70% of the total medicines are dispensed in the form of Tablet.

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Contents of the powerpoint on Steam Sterilization Theory And Equipment include:
Definitions
Sterile: Free from any living organisms
Sterilization: Process of killing or removing microorganisms from a product to insure that it is sterile

Type of agents
Chemical
Physical
Moist heat
Dry heat

Most clinics use physical agents

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Contents of the powerpoint on Plasticizers include:
INTRODUCTION
IDEAL PROPERTIES
CLASSIFICATION OF PLASTICIZERS
MECHANISM OF PLASTICIZATION
PLASTICIZERS USED IN
SOFTGELATIN CAPSULES AND TABLETS
EVALUATION OF PLASTICIZERS
APPLICATIONS
CONCLUSION
REFERENCES
A plasticizer is a substance which when added to a material, usually a plastic, makes it flexible, resilient and easier to handle.

They are colorless, odorless liquids produced by a simple chemical reaction, where by molecules of water are eliminated from petrochemical products.

They are not just additives. They are major components that determine the physical properties of polymer products.

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Contents of the powerpoint on pH Partition Theory include:
INTRODUCTION
pH-PARTITION THEORY
DRUG pKa AND GASTROINTESTINAL pH
LIPOPHILICITY AND DRUG ABSORPTION
DEVIATIONS FROM THE pH PARTITION THEORY
A UNIFYING HYPOTHESIS
CONCLUSION
REFERENCES

DRUG ABSORPTION:
Drug absorption is defined as the process of movement of unchanged drug from the site of administration to systemic circulation.

FACTORS INFLUENCING GI ABSORPTION OF A DRUG FROM ITS DOSAGE FORM:
They are classified in to two types:
PHARMACEUTIC FACTORS
PATIENT RELATED FACTORS

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• Contents of the powerpoint on Non Compartmental Pharmacokinetics include:
• Introduction to noncompartmental pharmacokinetic approach
• Differences between compartment and noncompartment models
• Concepts of noncompartmental model
• Statistical moments theory-Mean residence time
• Different pharmacokinetic parameters in noncompartment model
• Noncompartment pharmacokinetics is a new approach devised to study the time course of drug in the body with out assuming any compartment model.
  Based on the statistical moment theory.

Model independent method
Overcomes some of the drawbacks associated with
classical compartment modeling.
Basic assumption is that drug or metabolite follows
first-order kinetics.

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