Nutraceuticals and Dietary Supplements Course Syllabus Text Books

Nutraceuticals and Dietary Supplements -(2 Hr/Wk)

Course Objectives
1. To make the learner understand the concept of nutraceuticals and dietary supplements along with the classification with respect to
health benefits, chemical nature and mechanism of action
2. To expose the learner to the health benefits of various classes of phytochemicals along with their salient chemical features,
pharmacokinetics, doses and marketed preparations
3. To introduce to the learner the formulation challenges of nutraceuticals and health supplements and the importance of the safety and
stability of nutraceutical formulations
4. To make the learner aware of the regulatory aspects of nutraceuticals in India and major countries
Course Outcomes
Upon completion of the course student will be able to –
1. Explain concept of nutraceuticals and dietary supplements, classify these based on chemical nature, health benefits and mechanism
of action
2. Discuss the chemistry of phytochemicals, their health benefits, pharmacokinetics, interactions with food and recommended doses
along with the marketed preparations
3. Explain the challenges in formulating nutraceuticals
4. Understand the significance of safety and stability studies of nutraceuticals
5. Describe the labeling and regulatory aspects for manufacture and sale of nutraceutical products.
No. Details Hours
1 Introduction to Nutraceuticals
Definitions of Nutraceuticals, Functional foods, and Dietary supplements, Nutrigenomics. Link between Food and
Medicine. Food and No- food sources of nutraceutical factors, Nutraceutical factors in specific foods. Classification
of Nutraceutical. Factors based on chemical nature and mechanism of action. Safety, Scientific evidence and
market trends: Local and Global.
Self-study: Public health nutrition, maternal and child nutrition, nutrition and ageing, nutrition education in
community, Limitations of Nutraceuticals
2 Phytochemicals as Nutraceuticals:
Occurrence, Structure, Properties, Metabolism and Pharmacokinetics, Therapeutic uses, Recommended Doses and
Marketed Preparations of following
a) Carotenoids- Lycopene, Lutein, Zeaxanthene, Astaxanthene
b) Phenolics and Polyphenolics as Antioxidants – – Reservetrol , Grapeseed
extract, Tea, Pycnogenol, Avenanthramides from Oats, Rutin, Soy Isoflavones,
c) Sulphur Compounds- Glucosinates
d) Prebiotics / Probiotics-Fructo-oligosaccharides, Lactobacillum.
e) Dietary fibres – Soluble and insoluble any two examples each.
f) Lignans – Flax Lignans
g) Essential Fatty acids- Fish oils, α- Linolenic acid from Flax.
h) Quinones- Tocopherol.
i) Proteins and Minerals- Melatonin, Glutathione, Shilajit, Carnitine.
j) Marine nutraceuticals – Collagen from fish skin
3 Formulations and Challenges
Challenges involved in processing, extraction and concentration of nutraceutical constituents, formulations and
delivery systems, safety, storage and stability evaluation of formulations.
Labeling of Nutraceuticals
4 Safety and Toxicity of Nutraceuticals
Adverse Effects, Interactions, Adulteration- Intentional, counterfeiting, undeclared labeling, toxic contaminants
5 Regulatory issues of Nutraceuticals and Dietary Supplements
a) EU, US and Indian guidelines.
b) Regulatory Aspects; FSSAI, FDA, FPO, MPO, AGMARK. HACCP and
GMPs on Food Safety. Adulteration of foods.
c) Pharmacopoeial Specifications for dietary supplements and nutraceuticals


1. Handbook of Nutraceuticals and Functional Foods, Second Edition, Eds Robert E.C. Wildman, CRC Press, Taylor and Francis
2. Nutraceuticals: A Guide for Healthcare Professionals, Brian Lockwood
3. Nutraceuticals in Health and Disease Prevention edited by Klaus Kramer, Peter-Paul Hoppe, Lester Packer, Marcel Decker New
4. Nutraceuticals: Efficacy, Safety and Toxicity edited by Ramesh C. Gupta Academic Press, Elsevier Publication
5. Handbook of Nutraceuticals Volume I: Ingredients, Formulations, and Applications edited by Yashwant Vishnupant Pathak, CRC
Press, Taylor and Francis
6. Nutraceuticals edited by Alexandru Grumezescu, Academic Press Elsevier
7. Nutraceuticals, Glycemic Health and Type 2 Diabetes, Eds Vijai K. Pasupuleti, James W. Anderson, Wiley Blackwell Publications
8. Regulation of Functional Foods and Nutraceuticals: A Global Perspective, Ed Clare M. Hasler, Blackwell Publishing
9. Developing New Functional Food and Nutraceutical Products edited by Debasis Bagchi, Sreejayan Nair, Academic Press, Elsevier
10. Phytosterols as Functional Food Components and Nutraceuticals, Ed Paresh C. Dutta, Marcel Decker Publishing
11. Phenolics in Food and Nutraceuticals, Fereidoon Shahidi, Marian Naczk, CRC press
12. Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals, Eds Yoshinori Mine, Eunice Li-Chan, Bo Jiang, Wiley
13. Marine Nutraceuticals and Functional Foods, Ed Colin Barrow, Fereidoon Shahidi, CRC press
14. Role of dietary fibres and nutraceuticals in preventing diseases, K. T Agusti and P.Faizal, B S Publication
15. Goldberg, I. Functional Foods. Chapman and Hall, New York.
16. Labuza, T.P. Functional Foods and Dietary Supplements: Safety, Good Manufacturing Practice (GMPs) and Shelf Life Testing in
Essentials of Functional Foods, Eds M.K. Sachmidl and T.P. Labuza, Aspen Press.

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