Contents of the powerpoint on Efflux transporters include:
CONTENTS
INTRODUCTION
P-glycoprotein
Distribution & Structure
Substrates&inhibitors
Mechanism of drug transport
Pharmacokinetic implications of p-gp
Multidrug resistance associated proteins
Structure
Members of MRP family
Substrates&inhibitors
Transport cycle of MRPs
Clinical relavance of efflux transporters
Conclusion
References
Efflux transporters are positioned so as to encounter potentially harmful substances face-to-face — in important places like the intestine, the placenta, and the blood-brain and blood-testes barriers, making them an excellent first line of defense.
Embedded within a cell’s membrane, this protein protects a cell by ejecting a variety of molecules — in many cases, toxins —on contact. The cell might be a bacterium, in which case the “toxins” are antibiotics.
With cancer cells, the “poisons” are chemotherapy drugs.
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