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What is Schultz Dale Reaction
Schultz Dale reaction is an anaphylactic reaction produced in vitro during the testing of immunomodulatory drugs
What is the rationale behind Schultz Dale Reaction
It is used to initiate the release of mediators of anaphylaxis like histamine which induce contraction in smooth muscles.
How is Schultz Dale Reaction induced
To induce Schultz Dale reaction, guinea pigs are used generally. The animals are sensitized against egg albumin and three weeks after this, they are sacrificed. Ileum of the sacrificed animals is isolated and the contractility of the isolates is tested
Can we use any other tissues for Schultz Dale reaction?
Yes. Researchers have used lungs, tracheae of guinea pigs and trachea of mice as well.