[PPT] Volume Of Distribution


Contents of the powerpoint on Volume Of Distribution include:
Objective
Definition
Protein binding of drugs
Tissue binding of drugs
Factors affecting volume of distribution
Steady state volume of distribution
Relationship between clearance & VD & t1/2
Significance
Conclusion
References

To understand and describe the processes by which drugs are distributed throughout the body

To differentiate between apparent volume of distribution & true physiological volume

To understand the effect of protein and tissue binding on volume of drug distribution.

The volume of distribution (VD) , also known as apparent volume of distribution, is a pharmacological term used to quantify the distribution of a medication between plasma and the rest of the body after oral or parenteral dosing.

It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration.

The volume of distribution is a hypothetical volume of fluid into which a drug is distributed, it’s a useful in predicting amount of drug in the body.

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[PPT] Validation Of Raw Materials


Contents of the powerpoint on Validation Of Raw Materials include:
INTRODUCTION TO VALIDATION
DEFINITION OF VALIDATION
QUALITY ATTRIBUTES
WHY TO VALIDATE
WHEN TO VALIDATE
DEFINITION OF RAW MATERIAL
STEPS INVOLVED IN RAW MATERIAL VALIDATION
CONCLUSION
REFERENCES

Validation is the scientific study of a system
To prove that the facility/system/equipment/method is consistently doing what it is supposed to do (i.e., that the process is under control).

We want to make decisions based on good science and not hunches and assumptions!

To determine the process variables and acceptable limits for these variables, and to set-up appropriate in-process controls.

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[PPT] Types Of Tablets And Their Charecteristics


Contents of the powerpoint on Types Of Tablets And Their Charecteristics include:
Introduction
Classification of tablets
Characteristics of tablets
Conclusion
References

Tablet is defined as a compressed solid dosage form containing medicaments with or without excipients.

According to the Indian Pharmacopoeia Pharmaceutical tablets are solid, flat or biconvex dishes, unit dosage form, prepared by compressing a drugs or a mixture of drugs, with or without diluents.

They vary in shape and differ greatly in size and weight, depending on amount of medicinal substances and the intended mode of administration.

It is the most popular dosage form and 70% of the total medicines are dispensed in the form of Tablet.

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[PPT] Steam Sterilization Theory And Equipment


Contents of the powerpoint on Steam Sterilization Theory And Equipment include:
Definitions
Sterile: Free from any living organisms
Sterilization: Process of killing or removing microorganisms from a product to insure that it is sterile

Type of agents
Chemical
Physical
Moist heat
Dry heat

Most clinics use physical agents

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[PPT] Plasticizers


Contents of the powerpoint on Plasticizers include:
INTRODUCTION
IDEAL PROPERTIES
CLASSIFICATION OF PLASTICIZERS
MECHANISM OF PLASTICIZATION
PLASTICIZERS USED IN
SOFTGELATIN CAPSULES AND TABLETS
EVALUATION OF PLASTICIZERS
APPLICATIONS
CONCLUSION
REFERENCES
A plasticizer is a substance which when added to a material, usually a plastic, makes it flexible, resilient and easier to handle.

They are colorless, odorless liquids produced by a simple chemical reaction, where by molecules of water are eliminated from petrochemical products.

They are not just additives. They are major components that determine the physical properties of polymer products.

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[PPT] pH Partition Theory


Contents of the powerpoint on pH Partition Theory include:
INTRODUCTION
pH-PARTITION THEORY
DRUG pKa AND GASTROINTESTINAL pH
LIPOPHILICITY AND DRUG ABSORPTION
DEVIATIONS FROM THE pH PARTITION THEORY
A UNIFYING HYPOTHESIS
CONCLUSION
REFERENCES

DRUG ABSORPTION:
Drug absorption is defined as the process of movement of unchanged drug from the site of administration to systemic circulation.

FACTORS INFLUENCING GI ABSORPTION OF A DRUG FROM ITS DOSAGE FORM:
They are classified in to two types:
PHARMACEUTIC FACTORS
PATIENT RELATED FACTORS

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[PPT] Non Compartmental Pharmacokinetics

  • Contents of the powerpoint on Non Compartmental Pharmacokinetics include:
  • Introduction to noncompartmental pharmacokinetic approach
  • Differences between compartment and noncompartment models
  • Concepts of noncompartmental model
  • Statistical moments theory-Mean residence time
  • Different pharmacokinetic parameters in noncompartment model
  • Noncompartment pharmacokinetics is a new approach devised to study the time course of drug in the body with out assuming any compartment model.
    Based on the statistical moment theory.

Model independent method
Overcomes some of the drawbacks associated with
classical compartment modeling.
Basic assumption is that drug or metabolite follows
first-order kinetics.

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[PPT] Micheleis Menten Kinetics


Contents of the powerpoint on Micheleis Menten Kinetics include:
Linear and Non linear kinetics
Causes
The Michelis Menten kinetics
Introduction
Assumptions
Derivation
Important conclusions
Understanding Km and Vmax
Determination of Km and Vmax
In vitro , Lineweaver-Burk plot
In vivo
Applications

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[PPT] Methods Of Determining Absorption Rate Constant


Contents of the powerpoint on Methods Of Determining Absorption Rate Constant include:
Introduction
Methods To Detect Absorption Rate Constant

Method of Residuals
Wagner-Nelson Method
Loo – Riegelman Method
Deconvolution Method
Estimation of ka from Urinary Data

Significance of Absorption Rate Constants
Conclusion
References

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[PPT] Lozenges – Drug Delivery Vehicles


Contents of the powerpoint on Lozenges – Drug Delivery Vehicles include:
INTRODUCTION
SHAPES OF LOZENGES
TYPES OF LOZENGES
RAW MATERIALS
FORMULATION
MANUFACTURING
PACKAGING
STORAGE
QUALITY CONTROL
RECENT ADVANCES
CONCLUSION

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