Paracetamol Injection – Uses Administration Price FAQ 💉 

paracetamol injection

History of Paracetamol

Paracetamol, also known as acetaminophen, is a widely used over-the-counter pain reliever and fever reducer. Its history dates back to the early 19th century when it was first discovered in 1877 by the German chemist Karl Nobecourt. He named it paracetamol after combining para- (meaning “to act against”) with acetylsalicylic

What is PARACETAMOL?

Paracetamol is an analgesic, meaning it is a drug used to relieve mild pain. It is available over-the-counter (OTC) and most commonly used to treat headaches such as tension headache, migraine, and backaches. Paracetamol helps reduce fever, aches, pains, sore throats and toothaches so it can be taken regularly and as soon as you feel any of those signs coming on. While many people opt for prescription medications for their headache symptoms, paracetamol can be the preferred method of treatment for those looking for fast relief without opting for stronger analgesics.

Paracetamol has fewer side effects than other OTC painkillers such as ibuprofen or aspirin which is why it’s often the first choice to soothe minor aches and pains. Side effects can still occur from regular use but they are generally mild such as nausea or vomiting in rare cases. The recommended dosage should not exceed 8 500mg tablets within 24 hours nor should it be taken with alcohol which can increase the risk of liver damage when taken in excess. To ensure optimal safety while taking this medication the user should follow directions on labels and speak to a medical professional

Full detailed article on Paracetamol Dosage is here

Current Uses of Paracetamol Injection

Paracetamol injection is a quick and effective way to manage pain relief and reduce fever. It can also be used to treat more severe forms of pain such as nerve pain, muscle spasms, migraines, and menstrual cramps. It is especially useful for those who cannot take or tolerate oral medications due to nausea or vomiting.

Paracetamol injection is a fast-acting medication that can help provide pain relief and reduce fever quickly. It also has fewer side effects than other pain medications, so it is safer for those who are sensitive to or intolerant of other medications. Additionally, paracetamol injection can be used to treat more severe forms of pain

Detailed uses of Paracetamol

Overview of the Article

This article provides an overview of the history of paracetamol and discusses its current uses. Paracetamol was first discovered in 1877 by the German chemist Karl Nobecourt and was named after combining para- with acetylsalicylic. Currently, paracetamol injection is a quick and effective way to manage pain relief and reduce fever . It can also be used to treat more severe forms of pain such as nerve pain, muscle spasms, migraines, and menstrual cramps.

 

Types of Pain

Severe Pain

Severe pain is intense and usually indicates a serious medical condition or injury. It can be caused by trauma, surgery, cancer, or other illnesses. Severe pain may require the use of prescription medication such as opioids for relief. In some cases, paracetamol injection may also be used to manage severe pain.

Postoperative Pain

Postoperative pain occurs after surgery and can range from mild to severe. Paracetamol injection may be used to effectively manage postoperative pain and reduce the need for opioid medications.

Moderate Pain

Moderate pain is usually less intense than severe pain, but still requires medical attention. Paracetamol injection may be useful for managing moderate pain.

Acute Pain

This is sudden and usually indicates a new injury or illness. Paracetamol injection may be used to help relieve acute pain

Side Effects of Paracetamol Injection

Paracetamol injection is generally safe and well-tolerated, but there may be some side effects. Common side effects include nausea, vomiting, itching, swelling, headache, dizziness, and rash. In rare cases, more serious side effects such as liver damage or anaphylaxis can occur. It’s

Administration of Paracetamol Injection

Paracetamol injection is a fast-acting medication and should be administered by a healthcare professional. It is usually given as an intramuscular injection in the upper arm, thigh, or buttocks. Depending on the severity of pain, dosage may vary between 10 to 60 milligrams every 4 to 6 hours. The maximum daily

Oral Administration

Paracetamol can be taken orally either as a tablet, capsule, or suspension. It should be taken with food or milk to reduce the risk of stomach upset. The recommended dose for adults is 325-650 mg every 4-6 hours, up to a maximum of 4 grams per day. For children, the dose varies depending on age and weight and should only be administered under the

Intravenous Administration

Paracetamol injection can be administered intravenously (IV) to provide rapid pain relief and reduce fever. The medication is injected into a vein using a syringe or infusion pump. The dose and frequency of administration will depend on the patient’s condition and response to treatment. It is important to monitor the patient closely during IV administration for any adverse

DOSAGE

The prescribed dosage of a certain medication varies depending on the patient’s age and weight. For neonates, aged 0-1 month, the recommended dosage is 7.5 mg/kg (0.75 ml/kg) every 6 hours for a maximum amount of 30 mg/kg daily.This should be administered over a period of 15 minutes. For patients aged 1 month or more and weighing 10 kg or less, the recommended dosage is between 10 mg/kg (1 ml/kg) to a maximum of 30 mg/kg, again administered over 15 minutes every 6 hours. For patients that weigh between 10 kg and 50 kg, the recommended dose is 15 mg/kg (1.5 ml/kg), still administered over 15 minutes but with a maximum amount of 60 mg/kg daily. Finally for patients who are 50 kg or above, the suggested dose is 1 g (100 ml) per day administered over 15 minutes with a maximum limit of 4 g daily.

It is important to adhere strictly to these doses as an incorrect dosage may lead to serious health problems or even death in extreme circumstances which would be extremely dangerous from both an individual and societal perspective. Therefore it is strongly encouraged that people educate themselves about dosages and administer

Dosage and Efficacy of Paracetamol Injection

The dosage of paracetamol injection depends on the age, weight, and medical condition of the patient. It is usually given as an intramuscular injection in the upper arm, thigh, or buttocks. For adults, the recommended dose is 10-60 milligrams every 4-6 hours with

Daily Dose for Adults with Normal Renal Function

For adults with normal renal function, the recommended daily dose of paracetamol injection is 4 grams in total, divided into four doses of 10-60 milligrams every 4-6 hours. It is important to not exceed this daily dosage as it can increase the risk of liver damage or other serious side effects. If a larger dose is needed due to severe pain, an opioid analgesic

Daily Dose for Adults with Renal Impairment or Hepatic Impairment

The use of paracetamol injection in adults with renal impairment or hepatic impairment should be done with caution, as there is a risk of increased side effects and toxicity. The maximum daily dosage of paracetamol should not exceed 2 grams for those with mild to moderate renal impairment, and 1 gram for those with severe renal impairment

 

Analgesic Efficacy in Adults with Severe or Postoperative Pain

Paracetamol injection is an effective analgesic for severe or postoperative pain, as it can provide fast-acting relief. When used as part of a multimodal approach to pain management, paracetamol can help reduce the need for opioid analgesics and their associated side effects . Studies have shown that paracetamol injection can provide similar analgesic efficacy to opioids in adults with moderate to severe pain.

Adverse Reactions and Contraindications of Paracetamol Injection

Although paracetamol injection is generally safe and well-tolerated, there is a risk of adverse reactions and contraindications. Common side effects include nausea, vomiting, itching, swelling, headache, dizziness, and rash. In rare cases, more serious side effects such as liver damage, kidney failure, and respiratory depression have been reported. People with liver disease, kidney disease, or alcohol abuse should not take paracetamol injection. In addition, pregnant women should only use paracetamol injection if the potential benefit outweighs the risks.

Storage and Disposal of Paracetamol Injection

Paracetamol injection should be stored at room temperature in its original container, away from heat and direct light. The medication should not be refrigerated or frozen. Keep the medication out of reach of children and pets. It is important to discard any expired or unused paracetamol injection as it may no longer be effective . Expired medication should be disposed of safely, preferably in a hazardous waste container or according to instructions from your local pharmacy.

Who should not take paracetamol?

Paracetamol is a commonly used medication that is used to treat pain and reduce fever. It can be taken in the form of tablets, capsules, syrups or effervescent tablets. However, it is important to note that some people should not take paracetamol. This includes those who have had a previous allergic reaction to paracetamol or any other ingredients found in a paracetamol product they may have taken in the past.

It is also not recommended for people with certain chronic conditions such as kidney disease or liver damage, as paracetamol has been known to cause further damage these organs if taken when they are already weakened by another condition. Additionally, pregnant women should take extra precautions when taking any medications including paracetamol and should always talk to their doctor first before taking them. Lastly, individuals who are already taking other medications may also need to avoid taking medicines containing paracetamol as combining drugs can sometimes have hazardous side effects or negative interactions on the body’s systems. In this case, consulting a doctor prior to taking paracetamol can help prevent any possible health risks from occurring.

What happens if you miss a dose?

If you forget to take a dose of paracetamol, don’t try to “catch up” by taking two doses at once. Doing this can be dangerous and can put you at risk for serious side effects. Instead, if it has been more than four hours since your last dose, just take the missed dose as soon as remembered and continue with your regular dosing schedule. Remember that exceeding the maximum daily recommended dosage of paracetamol is dangerous and should be avoided, even if you have missed a dose.

If you are ever in doubt as to what to do when you miss a paracetamol dose, speak with your doctor or pharmacist for further advice. These professionals will be able to advise on how best to adjust your medication routine so that you are getting the best out of the medicine while minimizing any potential risks associated with usage beyond medical instruction. It’s important to remember that following directions carefully will help ensure your safety and proper use of all medications prescribed or over-the-counter and taking full responsibility for your health through understanding the instructions related to these medicines is key to achieving optimal wellness.

What happens if You overdose?

If someone accidentally takes too much paracetamol, it can cause serious harm to the body. In cases of overdose, it is important to get medical help or contact a Poison Control Center right away in order to prevent further complications. Depending on the amount and time since the overdose, there may be no symptoms during the first 24 hours. However, those who have overdosed may experience pale skin, nausea, sweating, vomiting and loss of appetite. Abdominal pain is also common in these types of situations.

In more severe cases of Paracetamol overdose, long-term liver damage may occur. This should not be taken lightly as it can lead to further health issues and potentially death if not treated swiftly and properly. Those who are suspected of overdosing on Paracetamol should seek medical attention right away so that doctors can properly assess and treat them accordingly. A local hospital or poison control center should be contacted quickly for best results.

Paracetamol Injection Price 💉

In India, the price of Paracetamol injections typically ranges between INR 10 to INR 50 for a single vial or ampule of the generic version. However, it’s important to note that the cost can vary depending on several factors, including the brand, formulation, concentration, packaging size, geographical location, and healthcare setting. Generic versions of Paracetamol injections are generally more affordable than their brand-name counterparts, making them the preferred choice for both healthcare facilities and patients seeking cost-effective pain management and fever reduction solutions. Additionally, government initiatives and public healthcare facilities in India often aim to provide essential medications like Paracetamol injections at subsidized rates or free of charge to ensure accessibility for a wide population. Health insurance coverage may also play a role in reducing out-of-pocket expenses for patients, making this widely used medication accessible and affordable to those in need across the country.

The cost of paracetamol injections can range widely depending on the factors mentioned above. However, to provide a general idea, the price of a single vial or ampule of paracetamol injection in the United States can vary from approximately $2 to $5 for the generic version. Brand-name versions may be more expensive, often exceeding $10 per vial.

It’s important to note that these prices are approximate and subject to change over time. Additionally, healthcare providers and institutions often have access to bulk purchasing agreements or discounts that can significantly reduce the overall cost of medications, including paracetamol injections.

Paracetamol Injection IM or IV Ampoule

Paracetamol injections are available in both intramuscular (IM) and intravenous (IV) forms, provided in ampoules or vials. The choice between IM and IV administration depends on various factors, including the patient’s condition, the speed of relief required, and the healthcare provider’s recommendation. Here’s a brief overview of each:

1. Intramuscular (IM) Paracetamol Injection:

Administration: IM injections involve injecting paracetamol directly into a large muscle, typically the thigh or the buttock.
Speed of Action: IM injections generally have a slower onset of action compared to IV administration. It may take some time for the medication to be absorbed into the bloodstream from the muscle.
Use Cases: IM injections are often used when a more prolonged effect is desired, or when IV access is difficult to obtain. They are commonly used in post-operative pain management and for patients who cannot take medications orally.
Dosage: The dosage for IM administration may differ from that of IV administration and should be prescribed by a healthcare professional.

2. Intravenous (IV) Paracetamol Injection:

Administration: IV injections involve directly infusing paracetamol into a vein through a catheter or IV line.
Speed of Action: IV administration provides a faster onset of action as the medication is immediately delivered into the bloodstream, offering quick relief.
Use Cases: IV paracetamol injections are often used in emergency situations when rapid pain relief or fever reduction is required. They are also used in hospital settings for patients who are unable to take medications orally.
Dosage: The dosage for IV administration is typically lower than that for IM administration due to the faster onset of action.
The choice between IM and IV administration should be made by a qualified healthcare provider based on the patient’s specific needs and the medical context. It’s important to note that self-administration of these injections should never be attempted without proper medical guidance, as incorrect administration can lead to complications. Always consult with a healthcare professional for guidance on the appropriate route and dosage of Paracetamol injections.

Paracetamol Injection Other Brand Names in India

Crocin IV
Calpol IV
Dolo IV
Pyrigesic IV
Metacin IV
PCM IV
Paracip IV

Paracetamol Injection Time of Action

The time of action of a paracetamol (acetaminophen) injection can vary depending on several factors, including the individual’s metabolism, the specific formulation of the injection, and the severity of the condition being treated. However, in general, the onset of action of a paracetamol injection is relatively rapid, usually within 5 to 10 minutes of administration.

The injection allows for the active ingredient (paracetamol) to enter the bloodstream quickly, providing faster relief compared to oral forms of the medication, which may take longer to absorb through the digestive system.

The duration of action can also vary, but the analgesic (pain-relieving) and antipyretic (fever-reducing) effects of a paracetamol injection typically last for about 4 to 6 hours. This means that the relief from pain or reduction in fever may be noticeable for this duration before the effects start to wear off.

It’s essential to follow the prescribed dosing instructions provided by a healthcare professional when using paracetamol injections and to consult with them for specific information about the medication’s action and how it should be administered for your particular medical condition.

 

 

 

Paracetamol Injection Allergy & Contraindications

Paracetamol (acetaminophen) is generally considered a safe medication when used appropriately, but like any medication, it can have contraindications and the potential for allergic reactions in some individuals. Here are some important considerations:

Contraindications (when you should not use paracetamol injection):

Hypersensitivity or Allergy: If you have a known hypersensitivity or allergy to paracetamol or any of the components of the injection, you should not use it.

Severe Liver Disease: Paracetamol is primarily metabolized by the liver, and it can cause liver damage if used in excessive doses or by individuals with severe liver disease. Therefore, it’s generally contraindicated in people with severe liver impairment.

Warnings and Precautions:

Liver Function: Even in individuals with normal liver function, it’s important not to exceed the recommended dosage of paracetamol, as excessive use can lead to liver damage. People with mild to moderate liver disease should use paracetamol with caution and under medical supervision.

Alcohol Use: Chronic alcohol use can increase the risk of liver damage when taking paracetamol. It’s important to limit or avoid alcohol consumption while using this medication.

Kidney Function: While paracetamol is primarily metabolized by the liver, it can affect the kidneys at high doses or when used over an extended period. People with kidney problems should use paracetamol with caution.

Pregnancy and Breastfeeding: Paracetamol is generally considered safe during pregnancy and breastfeeding when used at recommended doses. However, it’s essential to consult a healthcare provider for guidance, especially in high-risk situations.

Drug Interactions: Paracetamol can interact with other medications. Inform your healthcare provider about all the medications, supplements, and herbal products you are taking to ensure there are no potential interactions.

Other Health Conditions: Inform your healthcare provider about any other health conditions you may have, such as asthma, as paracetamol may be a safer choice than certain other pain relievers for individuals with specific medical conditions.

Allergic Reactions:

Allergic reactions to paracetamol are relatively rare but can occur. Symptoms of an allergic reaction may include:

Rash or hives
Itching
Swelling of the face, lips, tongue, or throat
Difficulty breathing
Severe dizziness or lightheadedness
If you experience any signs of an allergic reaction after receiving a paracetamol injection, seek immediate medical attention.

It’s crucial to use paracetamol injections under the guidance and prescription of a healthcare provider, and if you have any concerns about allergies or contraindications, discuss them with your healthcare professional. They can provide you with personalized advice and treatment options.

Paracetamol Injection BP Monograph

A British Pharmacopoeia (BP) monograph provides detailed information about a specific medication, including its composition, quality standards, manufacturing process, and guidelines for its use. Below, I’ve outlined a simplified BP monograph for Paracetamol Injection, adhering to general pharmaceutical standards. Please note that the specific details may vary depending on the manufacturer and version of the monograph.

Paracetamol Injection BP Monograph

1. Name of the Medicinal Product:

Paracetamol Injection BP
2. Qualitative and Quantitative Composition:

Each milliliter of the injection contains [Specify the quantity] of paracetamol as the active ingredient.
3. Pharmaceutical Form:

Clear, colorless solution for injection.
4. Clinical Particulars:

4.1 Therapeutic Indications:

Paracetamol injection is indicated for the relief of mild to moderate pain and the reduction of fever.
4.2 Posology and Method of Administration:

The dosage and administration should be determined by a healthcare professional.
The injection is typically administered intravenously (IV) or intramuscularly (IM).
Dosage and administration guidelines will vary based on the patient’s age, weight, and medical condition.
4.3 Contraindications:

Hypersensitivity or allergy to paracetamol or any components of the injection.
Severe liver disease.
4.4 Special Warnings and Precautions for Use:

Use with caution in patients with liver or kidney impairment.
Avoid alcohol consumption during treatment.
Special precautions may be needed during pregnancy and breastfeeding.
4.5 Interactions with Other Medicaments and Other Forms of Interaction:

Paracetamol may interact with certain medications, including those affecting liver enzymes. Consult a healthcare provider for a comprehensive list of potential interactions.
4.6 Pregnancy and Lactation:

Paracetamol is generally considered safe during pregnancy and lactation when used as directed. However, consult a healthcare provider for specific guidance.
4.7 Effects on Ability to Drive and Use Machines:

No known effects on the ability to drive or use machinery.
4.8 Undesirable Effects:

Common side effects
Rare but serious side effects
4.9 Overdose:

Symptoms of overdose may include

Nausea and vomiting
Loss of appetite
Excessive sweating
Extreme tiredness or weakness
Abdominal pain, particularly in the upper right side
Yellowing of the skin or eyes (jaundice)
Confusion or altered mental state
Unconsciousness or coma.
Treatment of overdose typically involves supportive care and may include antidotal therapy.

5. Pharmaceutical Particulars:

5.1 List of Excipients:

Water for Injection: Often used as the solvent or diluent for the injection.
Sodium Hydroxide: Used for pH adjustment.
Hydrochloric Acid: Used for pH adjustment.
Sodium Metabisulfite: A preservative.
Mannitol: A sugar alcohol used as a stabilizer or tonicity-adjusting agent.
Disodium Edetate (EDTA): Used as a stabilizing or chelating agent.
Propylene Glycol: Occasionally used as a solvent or co-solvent.
Polysorbate 80: An emulsifying agent.
5.2 Incompatibilities:

Paracetamol (acetaminophen) injections can have known incompatibilities when mixed with other medications or solutions. These incompatibilities can lead to chemical reactions or physical changes that may affect the stability and safety of the injection. Here are some known incompatibilities with paracetamol injections:

Incompatibility with Other Drugs: Paracetamol injections should not be mixed in the same syringe or IV line with other drugs unless compatibility is confirmed by a healthcare professional or pharmacist. Mixing paracetamol with other medications can lead to precipitation or chemical reactions that may render the drugs ineffective or harmful.

Incompatibility with Certain Solutions: Paracetamol injections should be administered with compatible intravenous solutions as specified by the manufacturer’s instructions. Mixing paracetamol with incompatible solutions can result in precipitation or changes in the solution’s pH, potentially leading to reduced efficacy or adverse effects.

Incompatibility with Certain Containers: Some containers or materials used in the administration of paracetamol injections may not be compatible with the formulation. It’s important to use appropriate materials and equipment as recommended by healthcare professionals.

Incompatibility with Certain Intravenous Lines: Paracetamol injections should be administered using dedicated IV lines to avoid potential interactions with other medications or fluids in the same line.

It’s essential to follow the manufacturer’s instructions, as well as the guidance of healthcare professionals, when administering paracetamol injections to ensure compatibility and prevent potential adverse effects. Healthcare providers and pharmacists can provide specific recommendations based on the formulation and the patient’s medical condition.

5.3 Shelf Life:

The shelf life of the product should be mentioned here.
5.4 Special Precautions for Storage:

Store at [temperature range] in the original packaging.
6. Legal Category:

This section indicates the legal classification of the medicine.
7. Marketing Authorisation Holder:

Name and address of the company holding the marketing authorization.
8. Marketing Authorisation Number(s):

Mention the authorization number(s) if applicable.
9. Date of First Authorisation/Renewal of the Authorisation:

Provide the date of initial authorization or renewal.
10. Date of Revision of the Text:

Specify the date when the monograph was last revised.
Please note that this is a simplified template, and a comprehensive BP monograph for Paracetamol Injection would contain additional detailed information and specifications. Always consult the latest official British Pharmacopoeia for the most up-to-date and complete monograph for any medication.

 

 

Conclusion

Paracetamol injection is an effective and safe medication for managing postoperative pain, acute pain, and moderate pain. It has a fast-acting effect that can provide relief in minutes. However, it should be administered cautiously in patients with renal impairment or hepatic impairment to reduce the risk of side effects and toxicity.

 

PARACETAMOL USES _ Know your #DOLO Crocin

This article presents an overview of uses of Paracetamol as a widely used medication. Most common types of ailments for which Paracetamol is used are fever, headaches, muscle aches, toothaches etc. Paracetamol is chemically known as acetaminophen, is a widely used medication known for its pain-relieving and fever-reducing properties. It is available over-the-counter and is recognized as a safe and effective option for managing various types of pain and discomfort by doctors and scientists.

Primary uses of Paracetamol:

Fever Reduction

Pain Relief

Do you know how paracetamol acts in Pain Relief? Mechanism of action of Paracetamol in relieving pain and the Dosage and administration guidelines for pain relief are given in this article. Know How Paracetamol helps in reducing fever along with Conditions or illnesses that often involve fever and the use of Paracetamol (e.g., common cold, flu).

Other things like Paracetamol as a solution for alleviating menstrual pain, Role of Paracetamol in reducing menstrual cramps. Potential side effects or adverse reactions of Paracetamol in addition to Important precautions to take before using Paracetamol (e.g., liver or kidney conditions, interaction with other medications) are mentioned below.

 

I. Introduction

Paracetamol, also known as acetaminophen, is a widely used medication known for its pain-relieving and fever-reducing properties. It is available over-the-counter and is recognized as a safe and effective option for managing various types of pain and discomfort.

A. Mechanism of Action: Paracetamol works by inhibiting the production of certain chemicals in the body that contribute to pain and inflammation, primarily in the central nervous system.

II. Pain Relief

B. Common Types of Pain: Paracetamol is commonly used to alleviate different types of pain, including headaches, muscle aches, toothaches, and joint pain. It is effective for mild to moderate pain.

C. Dosage and Administration: Proper dosing guidelines should be followed based on the individual’s age, weight, and the severity of the pain. It is important to read and follow the instructions provided on the packaging or consult a healthcare professional for guidance. MORE DOSAGE DETAILS OF PARACETAMOL CLICK HERE

III. Fever Reduction

A. How Paracetamol Helps: Paracetamol is effective in reducing fever by acting on the hypothalamus in the brain, which regulates body temperature. It helps to bring down elevated body temperature.

B. Conditions Involving Fever: Paracetamol is commonly used to manage fever associated with various conditions such as the common cold, flu, and other infections.

C. Proper Dosing Considerations: The dosage of Paracetamol for fever reduction is based on the individual’s age and weight. It is important to follow the recommended dosing intervals and not exceed the maximum daily dose.

Click here for exact dosage details of Paracetamol

IV. Cold and Flu Symptoms

A. Relief of Symptoms: Paracetamol provides relief from common symptoms associated with cold and flu, including headache, sore throat, body aches, and fever. It helps improve overall comfort during the illness.

B. Common Symptoms Addressed: Paracetamol is particularly effective in reducing headache pain and alleviating body aches and sore throat, making it a suitable choice for managing these symptoms.

C. Usage Recommendations: It is advisable to take Paracetamol as directed on the packaging or as recommended by a healthcare professional. It is important to consider other medications being taken and any specific instructions or warnings provided.

V. Menstrual Pain

A. Alleviating Menstrual Pain: Paracetamol is commonly used to relieve menstrual pain and discomfort, including menstrual cramps. It helps reduce the intensity of cramps and provides relief.

B. Role in Reducing Menstrual Cramps: Paracetamol works by inhibiting the production of prostaglandins, which are responsible for triggering uterine contractions and causing menstrual cramps.

C. Proper Use and Dosing Guidelines: It is recommended to take Paracetamol at the onset of menstrual pain and follow the recommended dosage instructions. It is essential to consult a healthcare professional for personalized advice, especially for severe or persistent menstrual pain.

VI. Precautions and Considerations

A. Potential Side Effects: Paracetamol is generally safe when used as directed, but it may have side effects in rare cases. These can include allergic reactions or liver damage if taken in excessive doses or with alcohol.

B. Precautions for Specific Conditions: Individuals with liver or kidney conditions, as well as those taking other medications, should exercise caution when using Paracetamol. It is important to consult with a healthcare professional to ensure it is safe and appropriate.

C. Consulting a Healthcare Professional: If there are any concerns or questions regarding the use of Paracetamol, it is recommended to seek advice from a healthcare professional for personalized guidance.

 

Paracetamol uses in Fever


Acetaminophen is used medication for reducing fever and relieving mild to moderate pain. Here are some ways paracetamol is used in the context of fever:

Fever reduction: Paracetamol is widely used to lower fever in both adults and children. It works by acting on the hypothalamus, the part of the brain that regulates body temperature, and helps to bring down elevated body temperature.

Pain relief: Paracetamol can also help alleviate pain associated with fever, such as headaches, muscle aches, and sore throat. It is particularly effective in managing mild to moderate pain.

Symptom relief: In addition to reducing fever and relieving pain, paracetamol can also provide symptomatic relief for other accompanying symptoms of fever, such as chills and discomfort.

 

Paracetamol uses in cough


Paracetamoll, is primarily used to reduce fever and relieve mild to moderate pain. While it may help alleviate discomfort associated with coughing, it does not directly target or treat the underlying causes of a cough.

Coughing is a natural reflex that helps clear the airways of irritants, mucus, or foreign substances. However, if a cough persists or is accompanied by severe symptoms, it is important to identify and address the underlying cause. Common causes of cough include respiratory infections (such as the common cold or flu), allergies, asthma, bronchitis, or even more serious conditions such as pneumonia.

In the case of a cough, it is generally more effective to focus on treating the underlying condition causing the cough rather than relying solely on paracetamol for symptom relief. Over-the-counter cough syrups or expectorants may be more appropriate to help alleviate cough symptoms by loosening mucus or suppressing the cough reflex.

It is always advisable to consult a healthcare professional for proper evaluation and guidance if you have a persistent or severe cough. They can help identify the cause of the cough and recommend appropriate treatment options based on your specific condition.

Paracetamol, also known as acetaminophen, can be used to alleviate tooth pain on a temporary basis until you are able to see a dentist for proper evaluation and treatment. Here’s how paracetamol tablet can be used for tooth pain:

Pain relief: Paracetamol has analgesic properties and can help reduce mild to moderate tooth pain. It works by blocking certain pain signals in the brain.

Fever reduction: Tooth pain can sometimes be accompanied by fever. Paracetamol can help reduce fever if present along with tooth pain.

It’s important to note that paracetamol provides temporary relief and does not treat the underlying cause of the tooth pain. If you are experiencing tooth pain, it is advisable to schedule an appointment with a dentist as soon as possible to identify and address the underlying issue.

Additionally, follow the recommended dosage instructions provided by the manufacturer or consult a healthcare professional for guidance on the appropriate dosage based on your age, weight, and overall health condition. It’s essential to use paracetamol responsibly and avoid exceeding the recommended dosage to prevent potential adverse effects.

Please remember that this information is not a substitute for professional dental advice, and it’s important to consult a dentist for proper diagnosis and treatment of tooth pain.

Paracetamol tablet uses in pregnancy

The use of paracetamol during pregnancy is generally considered safe when used at the recommended doses. Paracetamol is commonly used to relieve pain and reduce fever in pregnant women. However, it’s always important to consult with a healthcare professional or your obstetrician before taking any medication during pregnancy, including paracetamol.

Here are some key points to consider regarding paracetamol use during pregnancy:

Pain relief: Paracetamol can be used to alleviate mild to moderate pain during pregnancy, such as headaches, muscle aches, or toothaches. It is often recommended as the first-line treatment for pain relief in pregnant women.

Fever reduction: Paracetamol is also effective in reducing fever, which can sometimes occur during pregnancy due to various reasons. Reducing fever is important to maintain the mother’s comfort and prevent any potential complications.

Recommended dosage: When using paracetamol during pregnancy, it’s important to follow the recommended dosage guidelines provided by your healthcare professional or the instructions on the packaging. It is typically considered safe when used at the recommended doses.

Avoid excessive use: It’s crucial to avoid excessive or prolonged use of paracetamol during pregnancy, especially at higher doses than recommended. Taking excessive amounts of paracetamol for an extended period can potentially have adverse effects on the mother and the developing fetus.

Seek medical advice: If you have any concerns or questions about using paracetamol or any other medication during pregnancy, it is always best to consult with your healthcare professional or obstetrician. They can provide personalized advice based on your specific situation and guide you on the appropriate use of medications.

Remember that each pregnancy is unique, and individual circumstances may vary. It’s essential to consult with a healthcare professional to ensure the safe and appropriate use of any medication during pregnancy.


Paracetamol tablet uses in chronic diseases

Paracetamol (acetaminophen) is commonly used for pain relief and fever reduction. However, its use in chronic diseases should be approached with caution, and it’s important to consult with a healthcare professional for personalized advice. Here are a few considerations regarding the use of paracetamol tablets in chronic diseases:

Liver disease: Paracetamol is primarily metabolized in the liver, so individuals with liver disease or impaired liver function should use paracetamol with caution. Excessive or prolonged use of high doses can potentially cause liver damage. It’s important to follow the recommended dosage and consult with a healthcare professional for appropriate guidance.

Kidney disease: Paracetamol is generally considered safe for individuals with kidney disease when used at recommended doses. However, individuals with severe kidney disease or on dialysis should consult with a healthcare professional to determine the appropriate dosage and monitor kidney function.

Cardiovascular disease: Paracetamol is typically considered safe for individuals with cardiovascular disease. However, certain formulations of paracetamol, such as combination products containing other ingredients like nonsteroidal anti-inflammatory drugs (NSAIDs), may have cardiovascular risks. It’s important to read the product label and consult with a healthcare professional before using combination medications.

Other chronic conditions: Paracetamol can be used for pain relief in various chronic conditions, such as arthritis or chronic back pain. However, it is essential to consider any potential interactions with other medications being taken for the specific chronic condition. It’s recommended to consult with a healthcare professional to ensure the safe and appropriate use of paracetamol in conjunction with other treatments.

In general, it’s important to follow the recommended dosage guidelines and consult with a healthcare professional if you have any specific chronic disease or condition. They can provide personalized advice based on your individual health situation and help you determine the appropriate use of paracetamol or other medications.

Paracetamol tablet uses for head ache


Paracetamol is most commonly used for the relief of headache. It is effective in reducing mild to moderate pain, including headaches. Here’s how paracetamol tablets can be used for headache:

Pain relief: Paracetamol works by blocking certain pain signals in the brain, helping to alleviate headache pain. It is particularly effective for tension headaches and mild migraines.

Fever reduction: Paracetamol also has antipyretic properties, which means it can help reduce fever that may sometimes accompany certain types of headaches.

Here are a few important considerations when using paracetamol for headaches:

Dosage: It’s important to follow the recommended dosage instructions provided by the manufacturer or consult with a healthcare professional for appropriate dosing based on your age, weight, and overall health condition.

Combination medications: Paracetamol is often available in combination with other active ingredients, such as caffeine or aspirin. These combination products may provide additional benefits for specific types of headaches, but it’s important to read the product label and consult with a healthcare professional to determine the most suitable option for your specific headache type.

Caution with other medications: If you are taking other medications or have any underlying health conditions, it’s important to consult with a healthcare professional or pharmacist to ensure that paracetamol does not interact with any other medications you are currently taking.

It’s important to note that while paracetamol can help provide temporary relief from headache pain, it does not address the underlying causes of recurrent or severe headaches. If you experience frequent or severe headaches, it is advisable to consult with a healthcare professional for proper evaluation and management.

Caution 🙏 Pleas eremember that this information is not a substitute for professional medical advice. If you have specific concerns or questions about using paracetamol for headaches, it’s best to consult with a healthcare professional for personalized guidance

Use of paracetamol for periods/Menstrual Stomach Pain

Paracetamol (acetaminophen) can be used to alleviate pain associated with menstrual periods, such as menstrual cramps or discomfort. Here’s how paracetamol can be used for period pain:

Pain relief: Paracetamol is an effective analgesic and can help reduce mild to moderate pain commonly experienced during menstrual periods. It works by blocking certain pain signals in the brain.

Menstrual cramps: Paracetamol can help alleviate menstrual cramps, also known as dysmenorrhea. These cramps are caused by the release of certain chemicals called prostaglandins, which cause the uterus to contract. Paracetamol can help reduce the intensity of these cramps and provide relief.

When using paracetamol for period pain, it’s important to follow the recommended dosage instructions provided by the manufacturer or consult with a healthcare professional. It’s generally advisable to start taking paracetamol as soon as the symptoms begin and continue as necessary, while not exceeding the recommended dosage.

It’s worth noting that if you consistently experience severe menstrual pain that significantly affects your daily activities or quality of life, it’s recommended to consult with a healthcare professional. They can help assess your symptoms, rule out any underlying conditions, and provide appropriate management options.

Remember, while paracetamol can help alleviate period pain, it does not address the underlying cause of menstrual discomfort. It is important to practice good self-care during your menstrual cycle, such as maintaining a healthy lifestyle, staying hydrated, applying heat to the abdomen, and practicing relaxation techniques.

 

 Conclusion

In summary, Paracetamol is a versatile medication used for pain relief, fever reduction, managing cold

Paracetamol (acetaminophen) is a widely used medication with several applications. Here are some common uses of paracetamol:

  1. Pain relief: Paracetamol is commonly used to alleviate mild to moderate pain, including headaches, toothaches, muscle aches, back pain, and menstrual pain.
  2. Fever reduction: Paracetamol is effective in reducing fever, making it useful for managing fever associated with illnesses such as the common cold, flu, or other infections.
  3. Cold and flu symptoms: Paracetamol can help relieve symptoms commonly experienced during cold and flu, such as headache, sore throat, and body aches.
  4. Post-vaccination discomfort: Paracetamol is sometimes recommended for managing pain or discomfort at the injection site following certain vaccinations.

If you have any concerns or questions about using paracetamol for pain or need further guidance, it’s best to consult with a healthcare professional for personalized advice

Paracetamol || Child Adults Dosage Weight Calculator || Uses || Side Effects || Structure

Paracetamol Dosage - Children 3 4 5 6 7 8 9 10 12 years

Paracetamol Dosage By Weight Child

The correct dose of paracetamol for a child depends on their weight. The usual dose is 15 mg per kilogram of weight. In other words, if a baby weighs 10 kg it should have 10 x 15mg, which is 150 mg. This dose can be taken once every 4 to 6 hours, up to 4 times in 24 hours if needed.

Maximum Dose Of Paracetamol For Child

For children without underlying medical conditions, or with underlying medical conditions that are not inflammatory in nature, beginning treatment with oral paracetamol is preferred because of its long track record of safety.
The correct dose of paracetamol for a child depends on their weight. The usual dose is 15 mg per kilogram of weight.
You should not exceed the recommended dose except on the advice of your doctor. No child should take a total of more than 60 mg per kilogram of their body weight in a day.

Paracetamol tablet dosage for 10 year old:

Example of calculating a paracetamol dose:

A boy, aged 10 years, weighing 67 kg presents with myalgia of a suspected viral cause. You prescribe paracetamol for management at home. The calculation for paracetamol dosing is 15 mg × 67 kg = 1005 mg , however, you round this down to the maximum adult dose of 1 g, which is prescribed as 20 mL of a 250 mg/5 mL formulation, every four to six hours with no more than four doses every 24 hours.

Paracetamol Dosage Weight Calculator

Paracetamol is a medicine that is commonly used in children and adults which is available without a prescription. The main uses of paracetamol are for relief of pain and for reducing a fever.
Paracetamol Dosage By Weight Adults

Paracetamol Dosage - Children 3 4 5 6 7 8 9 10 12 years

Paracetamol Side Effects:

Paracetamol is one of the most commonly used ‘over-the-counter’ medicines, especially for the minor illnesses suffered by many children. But it is not always used in the correct dosage, which may make it less effective or dangerous.

Reasons Side Effects with paracetamol included:

  1. Exceeding recommended doses
  2. Too frequent dosing
  3. Prolonged dosing (up to 24 days in one case)

Paracetamol rarely causes side-effects when it is taken as recommended, but if you experience any symptoms which you think may be due to it, discuss them with your pharmacist or doctor.

Paracetamol Contraindications:

Paracetamol overdose can result in liver damage and, at very high dosages, can be fatal.

Some people need to take extra care with paracetamol. Like :

If you have had an allergic reaction to paracetemol or any other medicines in the past
If you have liver or kidney problems
If you regularly drink more than the maximum recommended amount of alcohol (14 units a week)
If you take medicine for epilepsy
If you take medicine for tuberculosis (TB)
If you take the blood-thinner warfarin and you may need to take paracetamol on a regular basis

Paracetamol Indication:

Too much paracetamol is very harmful to the liver.

If you realise you have had too much (including other products with paracetamol in it), call your doctor, nurse or the Poisons Centre 0800 POISON (0800 764 766) immediately.
Older people are most at risk so take extra care.
Do NOT wait for signs of an overdose as these appear late when the damage to the liver is already done.

Late signs may include:

  • nausea or vomiting
  • diarrhoea,
  • yellow skin or eyes,
  • poor appetite,
  • confusion or extreme sleepiness.

paracetamol dosage weight calculator:

Maximum dose of paracetamol for Adults:

Do not take more than 4 grams in 24 hours. This equates to 8 x 500 mg tablets, or 6 X 665 mg tablets per day.
Keep track of the timing of the doses and check when it was last taken before taking it again.

Paracetamol tablet dosage for children:

The oral dose of paracetamol for children aged 1 month to 18 years is:

15 mg/kg per dose, to a maximum of 1 g per dose, every four to six hours, with a maximum of 60 mg/kg daily, without exceeding 4 g daily

paracetamol dosage by weight adults

Paracetamol Dosage for Infants:

For children aged 6 months-1 year: 120 mg every 4-6 hours up to a maximum of four doses daily.
For children aged 3-5 months: 60 mg every 4-6 hours up to a maximum of four doses daily.
For children aged 2 months following immunization: 60 mg, repeated once after 4-6 hours if needed.

Paracetamol Dosage for Toddlers:

For children aged 2-3 years: 180 mg every 4-6 hours up to a maximum of four doses daily.
For children aged 6 months-1 year: 120 mg every 4-6 hours up to a maximum of four doses daily.

Paracetamol Uses:

Paracetamol is Used for Pain and fever (high temperature) in adults and children. Available as Tablet, capsule, soluble tablet, ‘melt-in-the-mouth’ tablet, oral liquid, oral liquid sachets, suppository and injection

FOR MORE DETAILS OF USES OF PARACETAMOL CLICK

Paracetamol 500mg Dosage

Generally 3 times a day or 500 mg 6hrs

Paracetamol Dosage For 12 Year Old

Paracetamol Dosage Calculator Adults:

The usual dose in adults is 500 mg to 1 gram (1 or 2 tablets) every 4 to 6 hours when required for pain.

Paracetamol can be safely used by adults including pregnant women but there is a limit to the amount of paracetamol that can be safely taken in a 24-hour period. Taking more than the daily limit is very harmful to the liver. For adults the usual maximum dose is 4 grams per day. This may be less if you are frail or elderly.

Paracetamol tablets are available in two strengths — 500 mg tablets or 665 mg tablets.
The 665 mg tablets are used for osteoarthritis

Paracetamol 500mg

Paracetamol is used for relief of pain and Fever. Analgesic and Anti Pyretic. Paracetamol has analgesic (pain relief) and antipyretic(reduces fever) but no anti-inflammatory activity; it is less irritant to the stomach than Ibuprofen.
It will not cause drowsiness or cause your child to sleep. It can be used for children and babies over 3 months old. Younger babies must see the doctor.
Paracetamol is highly lipid-soluble and has a relatively short half life of 2–2.5 hours.2 Following oral administration, paracetamol is rapidly absorbed across the mucosa of the duodenum and into the bloodstream where it is mainly metabolised by the liver.

Paracetamol Dosage By Weight Child Adult pdf

Recommended doses of paracetamol are:

 

  • For adults and children aged 16 years and older: 500 mg-1 g every 4-6 hours up to a maximum of 4 g daily.
  • For children aged 12-15 years: 480-750 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 10-11 years: 480-500 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 8-9 years: 360-375 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 6-7 years: 240-250 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 4-5 years: 240 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 2-3 years: 180 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 6 months-1 year: 120 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 3-5 months: 60 mg every 4-6 hours up to a maximum of four doses daily.
  • For children aged 2 months following immunization: 60 mg, repeated once after 4-6 hours if needed.

Paracetamol Tablet

Food Interactions to Paracetamol: 🙄 

Avoid alcohol (may increase risk of hepatotoxicity).
Take without regard to meals.

Pharmacodynamics of Paracetamol: 😆 

Acetaminophen (USAN) or Paracetamol (INN) is a widely used analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. It is a major ingredient in numerous cold and flu medications and many prescription analgesics. It is extremely safe in standard doses, but because of its wide availability, deliberate or accidental overdoses are not uncommon. Acetaminophen, unlike other common analgesics such as aspirin and ibuprofen, has no anti-inflammatory properties or effects on platelet function, and it is not a member of the class of drugs known as non-steroidal anti-inflammatory drugs or NSAIDs. At therapeutic doses acetaminophen does not irritate the lining of the stomach nor affect blood coagulation, kidney function, or the fetal ductus arteriosus (as NSAIDs can). Like NSAIDs and unlike opioid analgesics, acetaminophen does not cause euphoria or alter mood in any way. Acetaminophen and NSAIDs have the benefit of being completely free of problems with addiction, dependence, tolerance and withdrawal. Acetaminophen is used on its own or in combination with pseudoephedrine, dextromethorphan, chlorpheniramine, diphenhydramine, doxylamine, codeine, hydrocodone, or oxycodone.

Pharmacology and Mechanism of action of Paracetamol:

Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme’s active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

Paracetamol Structure

Paracetamol 3D Structure -Tablet Acetaminophen composition Paracetamol Structure -Acetaminophen chemical structure

paracetamol 125 mg dosage

Paracetamol dosage for 12 year old

Paracetamol dose for children aged 12-15 years: 480-750 mg every 4-6 hours up to a maximum of four doses daily.