Projects

List of B.Pharmacy & M. Pharmacy Projects to be done as a part of academic curriculum. Topics and ideas for project work of Pharmacy students are here today for you to help you a little bit in your academics to excel. When you are new to take up B.Pharm & M. Pharm project work we can say research work we http://pharmawiki.in are here today to help you choosing project title and topic. Topics for project in Pharmacology, Pharmaceutics, Pharmaceutical chemistry, pharmacognosy for B.Pharmacy & M. Pharmacy students in masters and bachelors final year. These Topics for project in Pharmacy for B.Pharmacy & M. Pharmacy will be of great help for the students who are going for the second year of master’s of pharmacy and also for the final year B.Pharmacy students.

B.Pharmacy & M. Pharmacy Projects topics

B.Pharmacy & M. Pharmacy Projects: Titles Project Work Topics {Pharmaceutics}

by
B.Pharmacy & M. Pharmacy Projects: Titles Project Work Topics {Pharmaceutics}

Hello Buddies. Here are few topics and title which can be used for B.Pharmacy & M. Pharmacy Projects in the final year. Particularly these are the Titles Project Work Topics for Pharmaceutics specialization. 

PHARMACEUTICS: B.Pharmacy & M. Pharmacy Projects: Topics For Project Work Of Pharmaceutics Students

 

  1. Formulation and evaluation of topical formulations of Bosweellic acids guggulosterones for the treatment of rheumatoid arthritis
  2. Supramolecular: Nanomedicine and nanotechnology pre-concentration, separation and recovery of toxic trace metal
  3. Supercritical fluid technology
  4. Studies on design and development of dissolvable oral drug delivery systems of a poorly water soluble non-steroidal anti-inflammatory drug
  5. Designing of a polyherbal formulation for metabolic disorder
  6. Development of lipidic drug delivery system for bioavailability improvement of the poorly water soluble antihypertensive drug
  7. Formulation, development of rapidly dissolving films containing anti-histaminic drug
  8. Formulation and Evaluation of colon targeted drug delivery systems
  9. Formulation, development and evaluation of controlled drug delivery of analgesics via novel routes
  10. B.Pharmacy & M. Pharmacy Projects: Titles Project Work Topics {Pharmaceutics}

b pharm projects topics and review articles:

  1. Rotary Tableting Press
  2. Finished Goods Quality Assurance.
  3. The Perfect Excipient
  4. Product Composition Affects Material Selection
  5. Fractional Experimental Design. Study of the Incompatibility of Benzocaine in Throat Lozenges
  6. Moisture content of tablet
  7. Stability of the colorant
  8. Changes in tablet hardness. friability. dissolution rate
  9. Formulation and evaluation of colon targeted drug delivery system of mebeverine hydrochloride
  10. Any significant pharmaceutical problem with the drug product related to its formulation, drug delivery and bio-availability.
  11. Methods and types of dosage form which already exsits in the market.
  12. Points you have to study and review for literature purpose:
  13. One should have to study the history of the drug thoroughly.
  14. Early and common problems related to exsisting dosage forms.

M.pharm project topics in pharmaceutics

  1. Drug-induced diseases and Teratogenicity
  2. Drug dependences, Drug abuse, addictive drugs and their treatment, complications.
  3. Introduction to drying processes – Study of Tray Dryers: fluidized Bed Dryer.
  4. Vacuum Dryer and Freeze Dryer.
  5. Viscosity-Imparting Agents in Disperse Systems
  6. Oral Aqueous Suspensions
  7. Topical Suspensions A review
  8. Bio-availability of drugs, including factors affecting it
  9. complete data base of drug available by any source like internet, libraries etc.
  10. Complete physico0chemical parameter of pure drug.
  11. Study of complete drug profile from authenticated sources like pharmacopoeias, FDA online sites etc.
  12. study of depth of the drug and its available formulations and problems related with that available problems.
  13. Development and assessment of Novel In-situ Ocular gels of Ketorolac Tromethamine
  14. Dissolution improvement of weakly soluble drugs using hot melt Extrusion Technology.
  15. Dissolution rate Enhancement of Glimepiride and olanzapine by spray drying technique.
  16. Enhancement of dissolution rate of aceclofenac with meglumin as a novel ternary component
  17. Formulation and estimate of Aceclofenac Topical Emulgels.

B.PHARMACY & M. PHARMACY PROJECTS: TOPICS FOR PROJECT WORK OF PHARMACEUTICS STUDENTS

  • Formulation and estimation of atomoxetine HCL buccal drug delivery system
  • Formulation and assessment of capecitabine tablets for colon specific drug delivery system
  • Formulation and Evaluation of cyclobenzaprine hydrochloride loaded sustained release microspheres.
  • Formulation and evaluation of diclofenac sodium matrix tablets using new natural polymer
  • Formulation and evaluation of duloxetine HCL delayed release enteric coated capsules
  • Formulation and evaluation of fast disintergrating tablets and films for carbinoxamine maleate
  • Formulation and evaluation of frusemide semi solid matrix capsules by liquid filling technology
  • Formulation and Evaluation of Glipizide microemulsion.
  • Formulation and evaluation of implantable drug delivery system for temozolamide
  • Formulation and evaluation of ornidazole topical emulgels
  • Formulation and Evaluation pantoprazole sodium enteric coated tablets using different super disintegrants.
  • Screening, optimization and characterization of polymers for orally dissolving films.

 

PHARMACEUTICS Project Topics: B.Pharmacy

 

Formulation, Evaluation And Validation Of Orally Disintegrating Rizatriptan Benzoate Tablet.

Sustained Release Effervescent Floating Bilayer Tablets A Review Of Novel Approach.

Nanocapsules: Nano Novel Drug Delivery System.

Formulation And Evaluation Of Atomoxetine Hydrochloride Sustained Release Tablets.

Nano-Particles Containing Anticancer Drug.

Solubility Enhancement Of Poorly Water Soluble Drug By Spherical Crystallization Technique.

In-Vitro Antiproliferative Activity Of M. Azedarach.

Impact And Management Tool For Identification And Reduction Of Human Errors In Pharmaceuticals Industry.

Solid Dispersion- A Review.

Validation-In Pharmaceutical Industry : Cleaning Validation – A Brief.

A Review On Gastro-Intestinal Drug Esomeprazole.

Effect Of Ascorbic Acid On Dissolution Stability Of Rifampicin In Market Fixed Dose Combination Products For Tuberculosis.

Prepration And Evaluation Of Nano-Emulsion Formulation By Using Spontaneous Emulsification.

Preparation Method, Properties And Crosslinking Of Hydrogel: A Review.

Formulation Development And In Vitro Evaluation Of Mouth Dissolving Tablets Of Pioglitazone Hydrochloride.

Formulation And Evaluation Of Orodispersible Tablets To Enhance Dissolution Rate Of Lamotrigine By Using Solid Dispersion Technique.

Formulation And Evaluation Of Metformin Hydrochloride Buccal Patch

Recent Pharmaceutics project topics – Current research topics

  1. Lipid Based Solid Self-Emulsifying Delivery System Of Pitavastatin Calcium: Development And Characterization
  2. Design And Characterization Of Paclitaxel Loaded Nanoparticles With Piperine
  3. Development And Characterization Of Topical Microemulsion Of Tranexamic Acid
  4. Exploring Career Advancement Of Pharmacy Support Staff Within Two Queensland Hospitals: A Qualitative Study
  5. Significant Predictors For Topiramate Pharmacokinetics: A Systematic Review Of Population Pharmacokinetic Studies
  6. Nanocapsule Formation By Interfacial Polymer Deposition Following Solvent Displacement
  7. Stability Indicating Reverse Phase High Performance Liquid Chromatography Method For Simultaneous Estimation Of Allantoin, Hydroquinone And Tretenoin In Cream Formulation.
  8. Process Control And End-Point Determination Of A Fluid Bed Granulation By Application Of Near Infra-Red Spectroscopy
  9. Chirality And Its Importance In Pharmaceutical Field-An Overview
  10. Recent Advances In Nanosponges As Drug Delivery System
  11. Fabrication Of Mebendazole Loaded Solid Lipid Nanoparticles: Formulation, Optimization, Characterization, Stabilization, And In-Vitro Evaluation
  12. In Vitro Evaluation And Characterization Of The Nanoparticulate System Of Novel Taxane Derivative
  13. A Comprehensive Review On Solid Lipid Nanoparticles As Delivery Vehicle For Enhanced Pharmacokinetic And Pharmacodynamic Activity Of Poorly Soluble Drugs

The above topics are from the recent work of the scientists and researchers. You can get an idea of the current trend in the Pharmaceutics department. Try to get more information on these type of research work from scholars or research papers and try to do your own way of the topics so that you can get amazing project for your M Pharmacy or B Pharmacy Project topics.

mpharmacy project topics idea name
ou m.pharmacy secind year project work dates
topics for m pharm thesis
m.pharm ceutics chemicals names
msc pharmacy project topic on pharmacognosy
project topics in pharmaceutics
regulatory affairs project titles
m pharm thesis
m pharma cwutics ke projact

official new project of pharmaceutical analysis
m.pharm p.ceutics various project

 

This article is updated now. M.pharm pharmaceutics project new list 2022

INDIAN JOURNALS List to Submit Pharmacy Research Papers – 50* Science

by
INDIAN JOURNALS List to Submit Pharmacy Research Papers - Science

Hello Readers. Here is the Indian Journals List to Submit Pharmacy Research Papers. You can submit your original work of your M Pharmacy or PhD on these journals. You know the value of the published papers in your career. So don not neglect write your paper under the guidance of your mentors and publish your research articles. You need to send your abstract then your approval will depend on the norms of the journal you submit. This is a list you can go through and find the best related journal to publish your paper or article.

List Indian Journals List to Submit Pharmacy Research Papers

1. Business India

2. Business Today

3. Business World

4. Chemical Weekly

5. CIMS

6. CSIR News

7. Current Literature on Science of Science

8. Current Science

9. Dataquest Magazine

10. Decision

11. DESIDOC Bulletin of Information Technology

12. Digit

13. Down to Earth

14. Drug One

15. Drugs & Pharmaceuticals-Current R & D Highlights

16. Drugs & Pharmaceuticals-Industry Highlights

17. Drugs Cases

18. Economic & Political Weekly

19. Electronics For You

20. Express Pharma

21. Fortune India

22. IDMA Bulletin

23. India Today

24. Indian Drug Reviews

25. Indian Drugs

26. Indian Journal of Biochemistry & Biophysics

27. Indian Journal of Chemical Technology

28. Indian Journal of Chemistry

29. Indian Journal of Experimental Biology

30. Indian Journal of History of Science

31. Indian Journal of Microbiology

32. Indian Journal of Pharmaceutical Education

33. Indian Journal of Pharmacology

34. Indian Management

35. Industrial Products Finder

36. Journal of Chemical Sciences

37. Journal of Food Science& Technology

38. Journal of Intellectual Property Rights

39. Journal of Marketing & Communication

40. Journal of Medicinal & Aromatic Plant Science

41. Journal of Scientific & Industrial Research

42. Management Review

43. Medicinal and Aromatic Plants Abstracts

44. MIMS India

45. Nandini Chemical Journal

46. Official Journal of the Patent Office

47. Outlook

48. Paradigm

49. Pharma Buz 50. PTI Science Service

51. Punjab University Research Journal

52. Scientific American India

53. Survey

54. Swamy News

55. Udymita Samachar Patra

56. University News

57. Vikalpa

58. Vision

59. Yojana

INDIAN JOURNALS List to Submit Pharmacy Research Papers - Science

This is a list of  Indian Journals List you can go through and find the best related journal to publish your Submit Pharmacy Research paper or article.

HPLC Detectors – Types Comparison Principles {PDF PPT}*

by
HPLC Detectors - Types Comparison Principles {PDF PPT}*

Here in this article we provide HPLC Detectors – Types Comparison Principles {PDF PPT}*.Different types of HPLC Detectors are given here for you for educational purpose. The HPLC detectors are used to detect the solute present in the eluent comes from the HPLC column. Different HPLC detectors are used in analysis of different types of samples to detect solute having different chemical nature.

HPLC Detectors – Types:

  1. 1. Ultraviolet/visible spectroscopic detectors{UV Detector/ VIS Detector}

    – Fixed Wavelength Detector
    – Variable Wavelength Detector
    – Diode array Detector
    PDA Detector

  2. 2. Refractive-Index Detector

    -Deflection Detector
    -Refractive Detector (Fresnel refractometer)

  3. 3. Evaporative Light Scattering Detector

  4. 4. Multi-Angle Light Scattering Detector

  5. 5. Mass Spectrometer

  6. 6. Conductivity Detector

  7. 7. Fluorescence Detector

  8. 8. Chemiluminescence Detector

  9. 9. Optical Rotation Detector

  10. 10. Electro Chemical Detector

HPLC Detectors Comparision – Best Detectors properties:

Regardless of the principle of operation, an ideal LC detector should have the following properties:
Low drift and noise level (particularly crucial in trace analysis).
High sensitivity.
Fast response.
Wide linear dynamic range (this simplifies quantitation).
Low dead volume (minimal peak broadening).
Cell design which eliminates remixing of the separated bands.
Insensitivity to changes in type of solvent, flow rate, and temperature.
Operational simplicity and reliability.
It should be tuneable so that detection can be optimized for different compounds.
It should be non-destructive.

HPLC Detectors Uses:

Most common Detectors of HPLC:

Refractive index
UV/Vis
Fixed wavelength (no longer used)
Variable wavelength
Diode array
Fluorescence

Less common, but important Detectors:

Conductivity
Mass-spectrometric (LC/MS)
Evaporative light scattering

HPLC Detectors - Types Comparison Principles {PDF PPT}*

HPLC Detectors – Types Comparison Principles {PDF PPT}*:

Variable-wavelength UV detectors:

Detectors which allow the selection of the operating wavelength called variable wavelength detectors and they are are particularly useful in three cases:
offer best sensitivity for any absorptive component by selecting an appropriate wavelength;
individual sample components have high absorptivity at different wavelengths and thus, operation at a single wavelength would reduce the system’s sensitivity;

Depending on the sophistication of the detector, wavelength change is done manually or programmed on a time basis into the memory of the system.

Any chemical compound could interact with the electromagnetic field. Beam of the electromagnetic radiation passed through the detector flow-cell will experience some change in its intensity due to this interaction. Measurement of this changes is the basis of the most optical HPLC detectors.
Radiation absorbance depends on the radiation wavelength and the functional groups of the chemical compound. Electromagnetic field depending on its energy (frequency) can interact with electrons causing their excitation and transfer onto the higher energetical level, or it can excite molecular bonds causing their vibration or rotation of the functional group. The intensity of the beam which energy corresponds to the possible transitions will decrease while it is passing through the flow-cell. According to the Lambert-Bear law absorbance of the radiation is proportional to the compound concentration in the cell and the length of the cell.

HPLC Detectors – Types Comparison Principles Power point {PDF PPT}

Multi-Angle Light Scattering Detector:

For the SEC analysis, MW of analyte is estimated from the calibration curve drown using a set of known standards. However, by using a MALS, MW can be determined directly without the need of calibration curve. Also MALS can provide an absolute MW of the analyte with very low detection limit.

Refractive index detectors:

These bulk property detectors are based on the change of refractive index of the eluant from the column with respect to pure mobile phase. Although they are widely used, the refractive index detectors suffer from several disadvantages – lack of high sensitivity, lack of suitability for gradient elution, and the need for strict temperature control (±0.001 °C) to operate at their highest sensitivity. A pulseless pump, or a reciprocating pump equipped with a pulse dampener, must also be employed. The effect of these limitations may to some extent be overcome by the use of differential systems in which the column eluant is compared with a reference flow of pure mobile phase. The two chief types of RI detector are as follows.

Deflection refractometer:

The deflection refractometer, which measures the deflection of a beam of monochromatic light by a double prism in which the reference and sample cells are separated by a diagonal glass divide. When both cells contain solvent of the same composition, no deflection of the light beam occurs; if, however, the composition of the column mobile phase is changed because of the presence of a solute, then the altered refractive index causes the beam to be deflected. The magnitude of this deflection is dependent on the concentration of the solute in the mobile phase.

Fresnel refractometer:

The Fresnel refractometer which measures the change in the fractions of reflected and transmitted light at a glass-liquid interface as the refractive index of the liquid changes. In this detector both the column mobile phase and a reference flow of solvent are passed through small cells on the back surface of a prism. When the two liquids are identical there is no difference between the two beams reaching the photocell, but when the mobile phase containing solute passes through the cell there is a change in the amount of light transmitted to the photocell, and a signal is produced. The smaller cell volume (about 3 ilL) in this detector makes it more suitable for high-efficiency columns but, for sensitive operation, the cell windows must be kept scrupulously clean.

HPLC Detectors – Types Comparison Principles PDF word document {PDF PPT}

Mass Spectrometer:

The analytes are detected based on their MW. The obtained information is especially useful for compound structure identification. However, its use is not limited to structure identification and can be used to quantify very low detection limit of elemental and molecular components.

hplc detectors pdf,
detectors used in gc,
hplc detectors principles,
hplc detectors ppt,
hplc detectors wikipedia, 
advantages of uv detector in hplc0, 
hplc detectors comparison,
pda detector in hplc

B.Pharmacy & M. Pharmacy Projects: Topics for project work of Pharmacology students

by
B.Pharmacy & M. Pharmacy Projects: Topics for project work of Pharmacology students

B.Pharmacy & M. Pharmacy Projects: Topics for project work of Pharmacology students are here today for you to help you a little bit in your academics to excel.  Topics for project in Pharmacology for B.Pharmacy & M. Pharmacy. These Topics for project in Pharmacology for B.Pharmacy & M. Pharmacy will be of great help for the students who are going for the second year of master’s of pharmacy and also for the final year B.Pharmacy students.

Topics for project in Pharmacology for B.Pharmacy & M. Pharmacy:

  • Emerging therapy for cancer.
  • Computer aided drug designing for targeted drug delivery systems.
  • Effect of combination therapy of Moxifloxacin and Dexamethasone on rats infected with Staphylococcus aureus.
  • Genetic level therapy for neonatal problems.
  • Which is superior -Azithromycin or Erythromycin?
  • Novel/Recent changes in fluoroquinolones.
  • Intradermal Anti-Rabies Vaccine – The new armament.
  • How to increase efficiency – Dosage or Concentration?
  • Common hazards of steroid use in hypertensives.
  • Emerging therapy for dengue.
  • Novel Routes of Insulin for Diabetes Treatment.
  • Applications of Nanotechnology in Cancer.
  • Colon Specific Drug Delivery System: An Overview.
  • Prostaglandins.
  • Parkinson’s disease novel drugs.
  • Advances in Thrombin Inhibitors.

New B.Pharmacy & M. Pharmacy Projects:

  1. Ophthalmic Inserts.
  2. Antioxidants from Natural Sources.
  3. Newer approaches in Treatment of pain: N – Type Calcium Channel Blocker.
  4. Nan robots and its Application in Medicine.
  5. Evaluation and Characterization of Bioadhesive Drug Delivery Systems.
  6. Gene Therapy in Cancer.
  7. Toxicology study of the effects of poisons.
  8. Theoretical pharmacology.
  9. Posology – how medicines are dosed.
  10. Pharmacognosy – deriving medicines from plants.

B.Pharmacy & M. Pharmacy Projects: Topics for project work of Pharmacology students

Latest B.Pharmacy & M. Pharmacy Projects:

Tumour Specific Drug Delivery: Novel Approches
Automated Drug Delivery System

New Approaches for Targeting to Treat Tuberculosis

Peptide Synthesis
Herbal Drugs Used in Skin Disorders
Peroxisome Proliferator Activated Receptor
A Molecular Update in G-Protein Coupled Receptor
Methods of Drug Discovery – Dynamics of Transition
Principles of Plant Toxins
Metered Dose Inhaler Technology
Molecular Modelling and Its Applications
Co-Processed Excipients
Erythropoeitin : An Update
Solid Phase Synthesis In Combinatorial Chemistry
Novel Liposomal Drug Delivery Systems And Their Applications
Computer Aided Drug Design
Biosensors
Dissolution Enhancement Techniques

 Click here to see  Ceutics B.Pharmacy & M. Pharmacy Projects: Titles Project Work Topics {Pharmaceutics}

Pharmacology B.Pharmacy & M. Pharmacy Projects:

Herbal Anticancer Drugs.
Clinical pharmacology – the medical field of medication effects on humans.
Neuropharmacology and Topic:Psychopharmacology (effects of medication on behavior and nervous system functioning),
Pharmacogenetics (clinical testing of genetic variation that gives rise to differing response to drugs)
Pharmacogenomics (application of genomic technologies to new drug discovery and further characterization of older drugs).
Pharmacoepidemiology (study of effects of drugs in large numbers of people).
Emerging therapy for diabetes.
Metabolic pharmacology/biochemistry.
Food-drug interaction.
Drug-drug interaction.
Clinical trial.
Toxicology related topics,
Pharmacological study of any unknown drugs.

Medicinal Chemistry Projects or Pharma Chemistry Projects for Masters / B Pharmacy

In Medicinal chemistry Projects B pharmacy and M Pharmacy students can take up wide variety of research topics which deals with Synthesis, Characterization and Docking Studies of some products, or Green Synthesis and Characterization of products, or In Silco Molecular Modeling or Cellular Redox State Modifications or High Throughput Kinetic Assay for Screening Potential Inhibitors. You can also try Method Development for Characterization of Novel products. Just you can make a list of your interested research topics for your B pharm and M Pharm projects and give them to your Guide. He or she will mentor you according to the current trend, necessity and resources availability.  

Below are few examples of projects for pharmacy students who are interested in Medicinal Chemistry. These are the current trending and ongoing project list from different places and institutes.

  1. Synthesis of Mukanadin B and Analogues as Possible Neuroprotective Agents
  2. Synthesizing novel self assembled monolayer conductive polymers for improving biocompatible and norotrophic devices
  3. Synthesis of Biologically Active Lignan Natural Products via an Acyl-Claisen Rearrangement and an Unusual 1,4-diaryl Rearrangement
  4. Studies towards the asymmetric synthesis of 1,4-benzodioxane neolignans
  5. Total Synthesis of the Dineolignan Ophiocerol and Derivatives
  6. Synthesis of bioactive natural products and associated analogues
  7. Vaccine design for lectin targets
  8. Design and synthesis of rat selective toxicants
  9. Development of bioactive 3C protease inhibitors as therapeutics to treat the common cold
  10. Novel Selective Ligands of the CB1/D2 Receptor Heterodimer
  11. Method Development for Characterization of Novel Copper Chelators in Patients with Diabetes
  12. Synthetic investigation of neurologically active therapeutic agents
  13. Synthesis of cyclic peptides isolated from a psychrophile\
  14. Total Synthesis of Aspergillus Spiroketal and its analogues
  15. Asymmetric gold-catalysed synthesis of the paecilospirone spiroacetal \
  16. Total synthesis of lasionectrin and related analogues as novel anti-malaria agents
  17. Synthesis of marine derived natural products Aigialospirol and its analogues
  18. Total synthesis of terreinol, a spiroketal natural product, and investigation into
  19. enantioselective oxidative spiroketalisation
  20. Studies towards onchidal’s acetycholine esterase inhibitory activit
  21. Design and synthesis of rat selective toxicants
  22. Development of bioactive 3C protease inhibitors as therapeutics to treat the common cold
  23. Novel Selective Ligands of the CB1/D2 Receptor Heterodimer
  24. Method Development for Characterization of Novel Copper Chelators in Patients with Diabetes
  25. Synthetic investigation of neurologically active therapeutic agents
  26. Synthesis of cyclic peptides isolated from a psychrophile
  27. Total Synthesis of Aspergillus Spiroketal and its analogues
  28. Asymmetric gold-catalysed synthesis of the paecilospirone spiroacetal
  29. Total synthesis of lasionectrin and related analogues as novel anti-malaria agents
  30. Synthesis of marine derived natural products Aigialospirol and its analogues
  31. Total synthesis of terreinol, a spiroketal natural product, and investigation into enantioselective oxidative spiroketalisation
  32. Studies towards onchidal’s acetycholine esterase inhibitory activity.

You can add any good ideas which you really think that will help pharmacy students and pharmawiki readers. Hope these Topics for project in Pharmacology for B.Pharmacy & M. Pharmacy really helped you. Keep tuned for more good updates.

An important rule for Drug selection for M.pharm Project- Lipinski’s Rule of five

by

How do you select a Drug for your M.pharm / Ph.D project based on Lipinski’s rule?

Selection of drug for M.Pharm / Ph.D projects is a very tough task. Getting a New drug itself is a challenging task. Then again there is another problem if the drug you selected is not available in the market. We get a doubt whether the drug is suitable to be made into a tablet or an emulsion. Of course we can know this by bioavailability studies in mice or another animals (maybe humans if the drug is safe) but again how would you feel if at the end of the day you dont get the results you expected?

So before we select a drug for oral use , (this includes not only tablets, capsules, emulsions and suspensions but also novel systems including Liposomes, nanoparticles, Gastro retentive drug delivery systems (GRDDs) and so on,) we need to ensure that our drug satisfies the Lipinski’s rule of Five.

What is Lipinski’s rule of Five

Lipinski’s rule states that, in general, an orally active drug has no more than one violation of the following criteria:

  • Not more than 5 hydrogen bond donors (nitrogen or oxygen atoms with one or more hydrogen atoms)
  • Not more than 10 hydrogen bond acceptors (nitrogen or oxygen atoms)
  • A molecular mass less than 500 daltons
  • An octanol-water partition coefficient log P not greater than 5

How this rule benefits your project?

The rule describes molecular properties important for a drug’s pharmacokinetics in the human body, including their absorption, distribution, metabolism, and excretion (“ADME”). However, the rule does not predict if a compound is pharmacologically active.
  1. This rule helps Pharmaceutics/Industrial Pharmacy students in proper selection of the drug and knowing whether the drug is suitable for oral formulations.
  2. For Medicinal chemistry students involved in drug designing, CADD, understanding this rule will help you a lot in designing suitable homologues of rugs and fine tuning your drug with suitable modifications

An Example from Lipinski’s original paper

Quoting from Christopher A. Lipinski … “Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings”:

“In the USAN set we found that the sum of Ns and Os in the molecular formula was greater than 10 in 12% of the compounds. Eleven percent of compounds had a MWT of over 500. Ten percent of compounds had a CLogP larger than 5 (or an MLogP larger than 4.15) and in 8% of compounds the sum of OHs and NHs in the chemical structure was larger than 5.

The Lipinski “Rule of Five” states that compounds are likely to have good absorption and permeation in biological systems and are more likely to be successful drug candidates if they meet the following criteria:

  1. five or fewer hydrogen-bond donors
  2. ten or fewer hydrogen-bond acceptors
  3. molecular weight less than or equal to 500
  4. calculated logP less than or equal to 5

*Compound classes that are substrates for biological transporters are exceptions to the rule.

If two parameters are out of range, a “poor absorption or permeability is possible” alert is a very visible educational tool for the chemist and serves as a tracking tool for the research organization.

More Resources

For more information and understanding follow these related resources:

  1. A powerpoint illustrating the basics is here:  Lipinski
  2. Wikipedia’s page on Lipinski’s rule of five http://en.wikipedia.org/wiki/Lipinski’s_Rule_of_Five
  3. The original paper of Lipinski is titled “Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings” and is avaialable on Science direct here or here Direct download
  4. There is a page on Facebook (YES!!!) which can be found here

  5. Lipinski Rule-of-5 calculator in ChemDraw/Excel . Get it here or here