NIPER Daily Booster Pack

Notes on Pharmacy related softwares for NIPER JEE preparation

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 Useful softwares: May be asked as questions in NIPER JEE

Chem Office / Chem Draw ultra: It is used to draw the structures of drug molecules in 2D and then to convert them in 3D, to find the IUPAC name of the unknown compound, to find the structure of the drug from its IUPAC name, to give NMR spectrum (approx) of unknown drug.

Software used to visualize the protein/ peptide 3D structure: Pymol, Rasmol, Jmol, Molmol, and VMD.

Structure Activity Relationship 2D QSAR, 3D QSAR: CoMFA,CoMSIA

Sequence alignment of proteins & nucleic acids: BLAST, FASTA, PROSPECTUS, COPIA

Gene finding and sequence analysis: Genscan, Glimmer

For sequence alignment of proteins: CLUSTAL W, CLUSTAL X

3D structure visualization, molecular dynamics, energy minimization: AMBER, CHARMM, HyperChem, chem2pac, GROMOS, GROMACS, MOE, SCHRODINGER

Molecular dynamics: MM2, MOPAC, AM1, PM

For quantum chemistry calculations: Gaussian

For statistical calculations: Sigmastat, Graphpad Prism, Sigma plot

For molecular design and drug design: Tripose, VLife

Structure drawing, 3D visualization of drugs and proteins: Alchemi, Cache, SYBYL

Cluster of many software used mainly for homology modeling: EMBOSS, GCG, Sybyl, Schrodinger.

For Docking (checking drug molecular fitting into receptor): Autodock, GOLD.

Toxicity prediction: Topkat

 

[gview file=”http://pharmawiki.in/wp-content/uploads/2012/06/Softwares.pdf”]

NIPER JEE – Mnemonics for drugs

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Mnemonics for easily remembering drugs and their adverse effects

Steroids side effects: BECLOMETHASONE:

  • Buffalo hump
  • Easy bruising
  • Cataracts
  • Larger appetite
  • Obesity
  • Moonface
  • Euphoria
  • Thin arms & legs
  • Hypertension/ Hyperglycaemia
  • Avascular necrosis of femoral head
  • Skin thinning
  • Osteoporosis
  • Negative nitrogen balance
  • Emotional liability

For more drugs Download pdf here

[gview file=”http://pharmawiki.in/wp-content/uploads/2012/06/Mnemonics-in-Tabular-form.pdf”]

Test Organisms for Microbiological Assay of Antibiotics

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Test Organisms for Microbiological Assay of Antibiotics
Antibiotic Test Organism ATCC No. NCTC No. (NCIB No.)
Amikacin Staphylococcus aureus

29737

7447
Amphotericin B Saccharomyces cerevisiae

9763

10716
Bacitracin Micrococcus luteus

10240

7743
Bleomycin Mycobacterium smegmatis

607
Carbenicillin Pseudomonas aeruginosa

25619
Doxycycline Staphylococcus aureus

29737

7447
Erythromycin Micrococcus luteus

9341

(8553)
Framycetin Bacillus pumilus

14884

8241
Bacillus subtilis

6633

 8236,10400
Gentamicin Staphylococcus epidermidis

12228

(8553)
Kanamycin sulphate Bacillus pumilus

14884

8241
Staphylococcus aureus

29737

7447
Kanamycin B Bacillus subtilis

6633

8236
Neomycin Staphylococcus epidermids

12228

(8553)
Novobiocin Staphylococcus epidermids

12228

(8553)
Nystatin SaccharomycesCerevisiae

2601

10716
Oxytetracycline Bacillus cereus var, mycoides

11778

10320
Staphylococcus aureus

29737

7447
Polymyxin B Bordetella bronchiseptica

4617

8344
Rifampicin Bacillus subtilis

6633

8236
Streptomycin Bacillus subtilis

6633

8236
Klebsiella pnumoniae

10031

(9111)
Tetracycline Bacillus Cereus

11778

10320

To download as pdf click here

NIPER JEE 2012 (syllabus) updated: 07/06/12 !!!

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NIPER JEE Syllabus

 (There is NO OFFICIAL syllabus provided for NIPER-JEE exam, but things outside this are rarely asked)

 Natural Products:

 

  1. In natural products more stress should be given on phytochemistry part rather than biological aspects but you should know about biological sources and chemical constituents of important ones.

 

  1. Methods of extraction, isolation and characterization of natural products. Various separation techniques used for isolation of natural products.

 

  1. Biosynthetic pathways.

 

  1. Primary metabolites, their examples.

 

  1. Secondary metabolites, various classes of secondary metabolites – Here most important part is chemistry of these classes. (e.g. Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins, anthocyanidines etc).

 

  1. Important therapeutic classes: antidiabetics, hepatoprotectives, immmunomodulators, neutraceuticals, natural products for gynecological disorders, anti-cancer, anti-viral (mainly anti-HIV), adaptogens etc. dietary antioxidants, marine natural products, plant growth regulators.

 

  1. Standardization of natural products.

 

  1. What is difference between natural products and pharmacognosy?

 

  1. Some knowledge about types and preparation of ayurvedic formulations like asava, arista etc.

 

  1. Stereochemistry and spectroscopy applied to some phytochemical constituents/ pure natural products- NMR, IR. Stereochemistry: Fischer, Sawhorse and Newman projection formulae.

 

References:
For various therapeutic classes: Trease and Evans

For spectroscopy: Silverstein, Pavia, Kemp

Download full syllabus here

[gview file=”http://pharmawiki.in/wp-content/uploads/2012/06/NIPER-JEE-Syllabus-2012-Updated.pdf”]

 

FDA Approved and Recalled drugs from Jan 2012 to May 2012

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FDA-Approved Drugs in 2012

Dermatology/Plastic Surgery

Sklice (ivermectin) lotion; Sanofi Pasteur; For the treatment of head lice, Approved February 2012

Endocrinology

Korlym (mifepristone); Corcept Therapeutics; For the control of hyperglycemia in adults with endogenous Cushing’s syndrome, Approved February 2012

Hematology

Elelyso (taliglucerasealfa); Pfizer Inc; For the treatment of Gaucher disease, Approved May 2012

Omontys (peginesatide); Affymax; For the treatment of anemia due to chronic kidney disease, Approved March 2012

Musculoskeletal

Stendra (avanafil); Vivus; For the treatment of erectile dysfunction, Approved April 2012

Oncology

Afinitor (everolimus); Novartis Pharmaceuticals Corporation; For the treatment of renal angiomyolipoma associated with tuberous sclerosis complex, Approved April 2012

Erivedge (vismodegib); Genentech; For the treatment of basal cell carcinoma, Approved January 2012

Inlyta (axitinib); Pfizer; For the treatment of advanced renal cell carcinoma, Approved January 2012

 

click here for more

[gview file=”http://pharmawiki.in/wp-content/uploads/2012/06/FDA-2012-Newly-approved-drugs-imp-for-niper-jee.pdf”]

FDA Approved and Recalled drugs from May 2011 to Dec 2011

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FDA-Approved Drugs in 2011

Cardiology/Vascular Diseases

Brilinta (ticagrelor); AstraZeneca; For the reduction of thrombotic events in patients with acute coronary syndrome, Approved July 2011

Edarbyclor (azilsartanmedoxomilandchlorthalidone); Takeda Pharmaceutical; For the treatment of hypertension, Approved December of 2011

Xarelto (rivaroxaban); Janssen Pharmaceuticals; For the reduction in the risk of stroke and systemic embolism resulting from atrial fibrillation, Approved November 2011

Dermatology/Plastic Surgery

Firazyr (icatibant); Shire; For the treatment of acute attacks of hereditary angioedema, Approved August of 2011

laViv (azficel–T); Fibrocell Science; For the improvement of nasolabial fold wrinkles in adults, Approved June 2011

Endocrinology

Tradjenta (linagliptin); Boehringer Ingelheim; For the treatment of type II diabetes, Approved May 2011

Gastroenterology

Dificid (fidaxomicin); Optimer Pharmaceuticals; For the treatment of Clostridium difficile-associated diarrhea, Approved May 2011

Incivek (telaprevir); Vertex; For the treatment of genotype 1 chronic hepatitis C, Approved May 2011

Victrelis (boceprevir); Merck; For the treatment of chronic hepatitis C genotype 1, Approved May 2011

 

for more click here

[gview file=”http://pharmawiki.in/wp-content/uploads/2012/06/FDA-2011-Newly-approved-drugs-imp-for-niper-2012.pdf”]