Pharmaceutical Equipment

Pharmaceutical equipment

In today’s life pharmaceutical products hold a very important position.  Most of us in our daily life need them some way or the other.  There is no respite from this by any means for the masses.  There are different types of pharmaceutical equipment available for use.  The list is quite big and has difference in use for different purposes.  Today we look at some of the most commonly used pharmaceutical equipment that are generally in use.

Pharmaceutical equipment Basics

Starting with the Automated/Integrated Workcell, it is quite often used in the Pharmaceutical industry.  It runs on quite a complex procedure and has got different types of intricacy with it.  Then there is the analytical balance that is used basically for class of balance designed to measure small mass in the sub-milligram ranges.  It has an enclosed dust door that help to provide a perfect pin point measurement.  Another one of the most important equipment that is used is termed as Autoclave.  This works as a pressure chamber.  It helps to carry out complex and difficult industrial processes.  It requires elevated temperature and pressure which is quite difference from that of the ambient air pressure.  Next is the BOD Incubator.  It is one of the finest pieces of incubator that works on low temperature.  There are different other types of other equipment that are used which provides the best result in pharmaceutical testing.

Now selection of a perfect equipment for a specific work is very important and requires years of experience and exposure to pharmaceutical work.  One needs to go through different stages of learning before one can get assured of the right equipment for the right process in action.  This is very much needed as the accuracy of the test depends entirely on the selection of apparatus and equipment in use.  Any inefficiency in this process can led to severe disaster in the result of the work or experiment done for manufacturing of pharmaceutical.  It will severely effect the compound manufacturing procedure which in turn can affect the patient or the consumer a great deal and would certainly have reverse and side effects once taken.

The quality of the finished product or rather the manufactured product much depends on the suitability and the level of the technology in use.  Most complex composition manufacturing needs complex procedures and in this case pharmaceutical equipment play a very very important part in the whole process.  Most of the pharmaceutical process today works on an automated process and involves less amount of manual involvement, but still the core of the process must always be guided in a proper way.  It must be always taken into consideration the amount of compound chemicals used, its form and proper combination of different compounds in a perfect percentage.

Pharmaceutical Equipment

Thus it can be easily concluded that Pharmaceutical equipment play a major part when the composition is made or being prepared for use.  It should always be noted that selection of proper equipment is very necessary to get cent percent final result.  It must also be noted that most of the pharmaceutical equipment that are being used runs automatically and needs less manual interference, but as stated above proper guidance is what is required as any lack of monitoring can provide an undesirable result to the finish product.  Most of the compound compositions used today are intricate and thus requires high end, sophisticated and heavy pharmaceutical equipment to use.  The bottom line is that in order to get the most and the best result of the pharmaceutical product one needs to heavily depend on pharmaceutical equipment that are being in use.

Tablet Press Machine – Parts Price Manual Manufacturers

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Tablet Press

Tablet press machine is used to press dry raw materials into tablet form. Tablet Press are increasingly used in a variety of industries to compress materials like Pharmaceuticals and Life Science Industries, Ayurveda Industries, Silica Industries, Confectionary Industries, Ferrites, Electronics and Defence Industries, Vitamins & Nutraceuticals Industries Salts, Detergents & Metals, API & Bulk Drugs, Food & Confectionary, Nutraceuticals, Ferrites.

Tablet Press Buyers Guide:

Important Specifications of Tablet Press You need to Check Before Buying:

  • Capacity of Torque main motor
  • Water cooling system
  • High Speed
  • Gravity Feeding System
  • Bi-Layer Tablet Attachment
  • Very low Noise level
  • Type of tooling D
  • Rated output (tablets / hour)*
  • Turret speed (rpm)
  • Max. Compaction force-Main (kN)
  • Max. Compaction force-Pre (kN)
  • Biometric Fingerprint lock system
  • Equal Pre & Main compaction of 100 kN
  • Single Tablet Rejection even at highest speed of operation
  • High & Updated Motorised Machine
  • Bi-Layer Tableting with a lot of ease and Separate first Layer Sampling available
  • Zero Clearance,
  • Machine Interlocks with indicating alarms as a Safety Device
  • Compaction Force Control (CFC) system for Auto Weight Control
  • Computer Panel for SCADA
  • 3 – Paddles Force Feeding System
  • Super Thick Upper Guards
  • Sound Reduction & Operator Safety
  • No. of station
  • Max. Tablet diameter (mm)
  • Max. Depth of die fill (mm)
  • Max. Tablet thickness (mm)
  • Upper punch penetration-Main & Pre comp. (mm)
  • Torque direct drive (kW / hp)
  • Power consumption (kW / hp)
  • Power supply
  • Overall dimensions (cm)
  • Net weight (kg)

 

Tablet Press Machine Parts=Principal components of Tablet Press:

• Hopper
• Fill Tray
• Dies
• Upper Punches and Lower Punches
• Turret
• Upper Tracking and Lower Tracking
• Upper Pressure Cam and Lower Pressure

• The Hopper holds the dry materials that will be compressed.
• The Fill Tray distributes the dry materials into the Die bores and pushes tablets into the Ejection Chute.
• The Dies define the size and shape of the powder.
• The Upper Punches and Lower Punches compress the materials within the Dies.
• The Turret houses the Tooling.
• The Upper Tracking and Lower Tracking guide the Tooling.
• The Upper Pressure Cam and Lower Pressure Cam compress the Upper Punches and Lower Punches to create the tablet.

Parts of Tablet Press

• Dont apply too much force to the powder.
• Dont Try to fill the Die with powder by hand.
• Dont insert Tooling that is too big for the machine.
• Properly mount the machine.
• Dont use powders that could explode under pressure.
• Dont use wet or damp material.
Be aware of risk of entanglement and pinch
point due to moving parts.
• Do not operate in a wet environment or with wet hands due to risk of electrical shock or burn.
• Do not operate if any wires are damaged,pinched, or frayed due to risk of electrical shock or burn.
• Keep fingers away from all moving parts.
• Ensure that machine is secure with antivibration feet on the workspace floor.
• Inspect machine before use.
• Check that nuts and bolts are suitably tightened.
• Use this machine only for its intended use as described in this manual.
• Do not modify the machine in any way.
• Turn off and unplug the machine before conducting cleaning and maintenance.

Tablet Press Machine Price

The price of the tablet press is different with different manufacturers. the price depends also on the purpose of the press designed for. the overall cost varies between 4 lakhs to 50 lakhs.

Dry Granulation – STEPS METHOD USES PPT PDF

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Dry Granulation

Dry granulation is a powder agglomeration process used in the pharmaceutical industry to improve the flowability of powders by increasing the particle size (granules). This operation is achieved using a roller press, which can have different configurations and equipment designs.
In simple terms Granulation is the process in which primary powder particles are made to adhere to form larger multiparticle entities called granules.

Dry granulation Roller compactor

Dry Granulation Advantages & Limitations:

(Slugging of rollercompaction)
Advantages:
* Eliminates exposure to moisture and drying.
* Dusty procedure.

This is also called double compression or slugging method, this is valuable alternative to direct compression,
where the dose of drug is too high or to wet granulation when the drug is sensitive to heat, moisture or both.
This method is also used when other methods of granulation yield granules with poor flow or compression
properties, because there are less chances of segregation of drug and excipients.

Limitations:
* Not suitable for all compounds.
* Slow process.

Long processing time, a relatively high capital investment on heavy duty presses or compactors.

 

Steps involved in dry granulation process

I. Milling of drugs and excipients
II. Mixing of milled powders
III. Compression into large, hard tablets to make slug
IV. Screening of slugs
V. Mixing with lubricant and disintegrating agent
VI. Tablet compression

 

In dry granulation method the primary powder particles are aggregated at high pressure. There are two main processes – either a large tablet (known as slug) is produced in a heavy duty tableting press( known as slugging) or the powder is squeezed between two rollers to produce a sheet of material (roller compaction) . The two different types are illustrated in below:

Slugging process

how well a material may slug will depend on the below terms

  1. Compressibility or cohesiveness of the matter,
  2. Compression ratio of powder
  3. Density of the powder
  4. Machine type
  5. Punch and die size
  6. Slug thickness
  7. Speed of compression
  8. Pressure used to produce slug

Granulation by slugging is the process of compressing dry powder of tablet formulation with tablet press having die cavity large enough in diameter to fill quickly. The accuracy or condition of slug is not too important. Only sufficient pressure to compact the powder into uniform slugs should be used. Once slugs are produced they are reduced to appropriate granule size for final compression by screening and milling

Slugging (Old Method)Slugging (Old Method) • material to be granulized is first made into a large compressed mass or “slug” typically by way of a tablet press using large flat-faced too long.

Disadvantages of Slugging:

  1. single batch processing
  2. frequent maintenance changeover
  3. poor process control
  4. poor economies of scale
  5. low manufacturing output per hour
  6. excessive air and sound pollution,
  7. Increased use of storage containers,
  8. more energy and time required to produce

Roller compaction:

In a roller compactor material particles are consolidated and densified by passing the material between two high-pressure rollers. The densified material from a roller compactor is then reduced to a uniform granule size by milling.
Roller compaction dry granulation process is capable of handling a large amount of material in a short period of time. As a special subtype briquetting utilizes special designed compaction rolls which divides the compacted powder in pieces (briquettes).
For dry granulation the compaction force in extend and uniformity of distribution is essential in regard to uniformity of granules porosity to ensure uniform hardness and disintegration of the final product. Because of its advantages, roll compaction is being increasingly used as a granulation technique, but it is not a simple process and may involve many variables for example roll pressure, roll speed, horizontal/vertical feed screw speed, roller gap, screen size. These parameters need to be optimized depending on the materials and the type of equipment used in order to obtain products of desirable quality.

Pneumatic Dry Granulation:

The pneumatic dry granulation process is a new and patent pending technology. The granulation process is based on the
use of roller compaction with very low compaction force together with a proprietary air classification method. The method enables production of granules with extraordinary combination of flow ability and compressibility. The granules produced by Pneumatic Dry Granulation and tablets produced show fast disintegration properties, offering the potential for fast
release dosage forms, and Release time can be tailored to requirements.
PDG technology can achieve, high drug loading, even with difficult APIs and combinations along with Taste masking and Excellent stability

 

References:

  1. Ankit Sharma, Pooja sethi, Dinesh pawar. “Granulation techniques and innovations”, Inventi Rapid: Pharmtech, Vol.10, 2011
  2. Himanshu.K.Solanki, Tarashankar Basuri, Jalaram H.Thakkar, “Recent advances in granulation technology, International Journal of Pharmaceutical Sciences Review and Research, 3(5), 48,2010 . 11.
  3. Nidhi Prakash Sapkal, Vaishali A. Kilor, Minal Nandkumar Bonde. Application of a convenient and cost and effective granulation technology for the formulation of tablets using conventional excipients, Asian Journal of Pharmaceutics – 225-254, 2014.
  4. Rudnic EM, Schwartz JD. Oral solid dosage forms In: Remington: The science and practice of pharmacy Gennaro, Lippincott Williams and Wilkins, USA, 2000: 858.
  5. Gohel MC. A review of co-processed directly compressible excipients. J Pharm Pharmaceut Sci 2005; 8: 76-93.
  6. Schwartz JB, Fonner DE, Anderson NR, Banker GS. Granulation and tablet characteristics, Lieberman HA, Lachman L, eds. Pharmaceutical Dosage Forms: Tablets. Vol. 2, New York, Marcel Dekker, 1981:201.

Pharmaceutical Equipment & Machinery

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Pharmaceutical Equipment & Machinery

Pharmaceutical Equipment & Machinery

 When we speak about Pharmaceutical equipment & machinery we speak about endless number of equipment and machinery that are being used on a day to day basis in order to improve the quality of pharmaceutical products and its activities towards treatment.  The field of pharmaceutical requirements is huge and is tied up with different avenues which make it more important for the equipment’s and machinery to work perfectly and produce high quality of products that are error free on a whole.  Today we will be trying shredding few lights on some of the equipment and machinery in use and a little bit about how they are working.

Firstly speaking about the pharmaceutical equipment there are many different types and sizes that are found.  Each of them perform specific tasks and have their own distinct actions as well.  One of such is Homogenizer Equipment which under high pressure reduces the size of the pharmaceutical product particles and provides turbulence, impact and acceleration along with it making them more clinically effective and stable.  Then there is Pharmaceutical Drying Equipment which has the capability of gently drying of pharma ingredients especially crystallization from water by means of filter process or from one or more organic solvents.  Speaking about the pharmaceutical filling equipment, these equipment are specifically used for expediting small and large scale product manufacturing with providing constant output demands.  The equipment works on automated or semi-automated control.  Out of different types of instrument and equipment that are being used one of such equipment that have a very effective part to take place is Powder filling equipment.  These equipment are used to fill the pharmaceutical powder products.  The equipment works automatically and helps in the production.  There is the Auger filling machine as well which also works in the same way as Powder filling equipment.  There are different other equipment like spray drying accessories, syringe filling equipment, Vial filling equipment, pharmaceutical checkweighers, pharmaceutical extrusion equipment which have their own functionalities and working procedures.

Pharmaceutical Equipment & Machinery

Now speaking about Pharmaceutical machinery, the use and application of them in case of pharmaceutical products does have a high significance.  There are different types of machinery that are into use namely, Vibro sifter, Tablet Press, tableting machine, Rapid mixer granulator, Mass mixer, multi mill, coating pan, V blender, tablet making machines, tablet coating machines, sigma mixer and the list is endless.  Now where tablet press, a specific machine that is used for compressing powder into tablet and giving it a specific form and shape, Pharmaceutical Vibro sifter is used for separating different materials based on the size of their particle and use.  The tableting machine is another very important machinery that is used in the pharmaceutical production houses.  This device is used for making tablets for consumption.  Rapid mixer granulator is another important machine that is used for formation of granules by the process of rising, tumbling and whirling motion of material.  The drying machine is done by adding up all the ingredients into the RMG.  Mass mixer is used for mixing of ingredients whereas multi mill, a self contained portable unit is used for shredding, high speed granulating, mixing, pulversing and chopping purposes.  It has multifunctional working capabilities and one of the most prime machinery used in pharmaceutical production houses.

On conclusion it can be easily said that these machinery and equipment are an integral part of pharmaceutical production and without their use things would have been something very much different and difficult to handle.  These products cost very highly due to the extreme capabilities they possesses and thus needs proper guidance when handling.

Preliminary Hazard Analysis (PHA) Determine Equipment Re-qualification Frequency

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Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

An Introduction to Equipment Qualification

The pharmaceutical industry induces full of experiments and it often requires conducting batch reactions using toxic or flammable materials. In many cases, complex chemical reactions are carried out with significant energy release. Such exothermic reactions processing can cause fire, explosion or runaway reaction hazards and these are quite life threatening for personnel and facilities. Equipment qualification is a critical step in overall process validation (PV), typically referred to as Stage 2A of the PV life cycle. It is outlined in many regulation and guidelines, including the FDA’s 2011 Process Validation Guidance and Annex 15 of the EU GMP, among others.

While handling the Equipment, one is likely to face the ambiguity of how often to do a given task or activity using them. It is necessary for the equipment to be periodically re-qualified if there is a performance dip with consistent working to ensure the quality of products. Here the focus is on the re-qualification decision-making framework based on the use of the preliminary hazard analysis (PHA), a tool used in quality risk management.

Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

Prior to use in production or quality control testing all new equipment should require passing through all stages of qualification such as

  • Design qualification (DQ)
  • Installation qualification (IQ)
  • Operational qualification (OQ)
  • Performance qualification (PQ)

A robust equipment qualification program is appropriate based on the uses and risks of the equipment. The activities of each of these qualification steps should be well documented, to provide evidence that the equipment is fit for its intended purpose, and those records should be available for review by request.

Stages of equipment and instrument qualification

Figure 1: Stages of equipment and instrument qualification

In the figure above, if we follow the illustration we see that once the equipment has been initially qualified, the qualification program should speak to the periodic re-qualification of equipment. It is a part of implementing any changes through a defined change control process impacting the qualified state of the equipment. Based on the criticality of the equipment used in production or on the quality control testing of products the extent of the re-qualification should be done.  Documentation of the periodic review of pertinent data is indispensable to confirm that a process/method/system continues to consistently produce a result meeting predetermined acceptance criteria.

PRINCIPLES OF QUALITY RISK MANAGEMENT

Two primary principles of quality risk management in the pharmaceutical industry are:

  • The risk evaluation of quality should be based on scientific knowledge and concern about the protection of the personnel and facilities.
  • The quality risk management process should be commensurate with the level of risk with respect to the level of effort, formality, and documentation.

ICH Q9 on Preliminary Hazard Analysis (PHA)

As continuing to the question of “When or at what frequency should the periodic review is performed?”  How should one structure the program to help the user determine when to perform the review? What guidelines to follow to create this aspect of the qualification program?

The answer to these is to perform the ICH Q9 (Quality Risk Management) – the risk management tool PHA. According to ICH Q9, the definition of PHA is that it is a tool to analyse hazardous situations and events that might cause harm, to estimate probable hazards in occurrence for a given activity, facility, product or system based on applying prior experience or knowledge of a hazard or failure to identify future hazards.

The tool consists of the following components:

  • identification of the possibilities that the risk event happens
  • qualitative evaluation of the extent of possible injury or damage to health as an outcome
  • using a combination of severity and likelihood of occurrence, relative ranking of the hazard is given
  • the detection of the possible remedial measures

Figure 2 denotes the PHA worksheet. If we can build a worksheet to organize the analysis and assist with the facilitation of the activities, the PHA tool could essentially address all the review of the parameters, as well as correlate the risk priority ranking to a periodic review frequency for the subject equipment.

It requires team expertise in the quality risk management process, how to use the PHA tool, scoring criteria, and key definitions. It generally consists of equipment owners, process owners, and quality assurance to perform the analysis possessing a strong understanding of the whole hazard analysis. The inputs of each column to the worksheet are directed and provided by a two-step triage approach using risk blocks scored against criteria as high, medium, and low rankings as in Tables 1, 2, and 3.

Figure 2: PHA worksheet example

 

 

 PHA work sheet example

 

 

Table 1: Severity Rankings

Severity Rankings

 Table 2: Probability (Occurrence) Rankings

Probability (Occurrence) Rankings

 Table 3: Detectability Rankings

Figure 3: Risk class determination

The preliminary risk class based on severity and probability (or occurrence) was first determined as in Figure 3.

Risk priority ranking

Figure 4: Risk priority ranking

Risk priority ranking

Table 4: Example of Periodic Review Frequency

Further the hazard parameters are evaluated against detect-ability, resulting in a risk priority ranking (Figure 4). It correlates to the periodic review frequency for the subject equipment (Table 4). Once the worksheet is completed with input from team members, the periodic review frequencies should be reviewed and agreed to by all. The following PHA worksheet (Figure 5) provides an example of a completed analysis activity.

Figure 5: PHA worksheet example — completed analysis activity

 

PHA worksheet example — completed analysis activity
PHA worksheet example — completed analysis activity

Inferences drawn about how this method of hazard analysis can be beneficial

  • The PHA tool enables to build a usable worksheet allowing all members of the team to participate in the risk analysis activity to provide subject matter expertise, voice concerns, and promote issues for further discussion.
  • Additionally, by facilitating the team meetings, time schedules were managed and those issues that were a challenge were tabled and discussed offline.
  • At the end of each completed worksheet, team members provide feedback regarding the risk analysis activity noting the efficient use of time, effective use of risk management tools, and delivery of risk priority rankings for subject equipment in correlation with the periodicity frequency.
  • Therefore, using a risk management tool such as PHA, a periodic review frequency can be identified and applied to qualified equipment. This enables a timely recheck of the equipment by means of pertinent data like manufacturing performance trend data, change history, and/or deviation history and that in turn would help in assuring consistent production results meeting the predetermined acceptance criteria.

Formulation Equipment List – Pharmaceutical Formulation Machinery PDF

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Formulation Equipment List - Pharmaceutical Formulation Machinery PDF

In pharmaceuticals, formulation (or dosage form) refers to the creation of a structure such as a capsule, a pill, tablet, or an emulsion, prepared according to a specific procedure or “formula”. Competently designed formulations for particular applications are safer, more effective, and more economical than any of their components used singly. There are a range of automated and semi-automated machines and equipment that can assist in the highest quality formulation of pharmaceuticals.

The pharmaceutical industry has the most precise requirements and manufacturing guidelines in terms of quality. As a result, it is critical that pharmaceutical manufacturing equipment comply with good manufacturing practice (GMP). Pharmaceutical manufacturing equipment includes a wide variety of equipment, such as capsule filling machines, x-ray inspection systems, and spray drying accessories. In order to ensure precise manufacturing and formulation development, almost every process can be automated. As a result, there is a piece of pharmaceutical manufacturing equipment involved in every step. 

PDF Formulation Equipment List 

Pharmaceutical Formulation Machinery

  • Economic tablet press
  • Single rotary tablet press
  • Laboratory capsule filler for liquid solutions
  • Automatic capsule filler for liquid solutions
  • Automatic laboratory capsule filler
  • Contained capsule filler
  • High-yield capsule filler
  • Automatic tablet coater for lab scale
  • Tablet auto coater for lab scale
  • Microencapsulation system for your drug delivery system
  • Waste minimization weight sorter for tablets & capsules
  • High capacity weight sorter for tablets & capsules
  • Major Formulation Equipment
  • Homogenizer
  • Filler
  • Vector FLM-1 and FLM-3
  • fluid bed processors
  • High Shear Granulator 
  • Planetary Mixer
  • High shear granulator/blender 
  • V blenders: 
  • Single station tablet press
  • Instrumented sixteen station tablet press (“B” Tooling)
  • Benchtop encapsulation machines (2 pc. Hard-shell)
  • Various semiautomatic compression and encapsulation machines
  • Various granulation and compounding equipment
  • Capsule Sealer & Capsule Printer
  • Perforated coating pans (15″, 19″, 24″ & 36″)
  • Dome extruder
  • spheronizer
  • Comil
  • Wurster columns 
  • Conventional coating pan
  • Formulation Equipment List - Pharmaceutical Formulation Machinery PDF

Today’s technology has much improved with the advancement of time.  Science has provided us with different ways in order to motivate our life and get the best out of it.  A revolution has also taken place in terms of manufacturing and processing machinery as well.  Over the last decade things seems to have change drastically and has provides us with a new horizon of opportunities that we can boost with and help our life grow bigger and better over the coming days.  Manufacturing and processing machinery today has greatly changed over the course of time and most have touch different avenues and left a mark for itself to carry on with.  Today we are going to discussed about some of the formulation and processing machinery and next articles we see how it has changed human life.

List of Medical Laboratory Equipment | Lab Supplies | Clinical Pharma Lab Devices

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List of Medical Laboratory Equipment lab supplies instruments used clinical and pharma lab

In this article we deal with the list of Medical Laboratory Equipment and all lab supplies and Instruments.  Clinical  Laboratory Devices are also included in the list. Pharmaceutical equipment always play a vital part in production of the pharmaceutical products.  There are wide range of products that are involved with this process from big to small, light to heavy, semi-automated to fully automated, metal to steel and of different shapes and sizes.  Today we try to list up some of the most important of the pharmaceutical equipment that are generally used in the production unit.

List of Medical Laboratory Equipment

The list is as follows below:

List of Medical Laboratory Equipment lab supplies instruments used clinical and pharma lab

  • Blood Pressure Systems/Blood Pressure Monitor
  • Capnograph/Capnography Monitor
  • Lab Animal Exercise / Walking System
  • Laboratory Animal Anaesthesia System
  • Physiological Monitor
  • Cryogenic Shippers / Cryoshipper
  • Laboratory Refrigerator Freezer
  • Liquid Nitrogen Canister / Liquid Nitrogen Dewar
  • Liquid Nitrogen Freezer / LN2 Freezers
  • Minus 20 freezer (-20C to -40C Freezers)
  • Minus 80 Freezer (-86 Freezer)
  • Plasma Freezer / Blood Bank Freezer
  • Tissue Freezer
  • Ultra Low Temperature Freezer (ULT Freezers)
  • Laboratory Animal Monitoring
  • Forensic Workstation / Forensic Hood
  • Laboratory Freeze Dryer
  • Laboratory Hoods
  • Cage Changing Hoods
  • Cell Processing Work Station
  • Glove Boxes
  • IVF Workstation
  • Laboratory Fume Hoods
  • Laminar Flow Hoods / Biological Safety Cabinets
  • PCR Workstation / PCR Cabinet
  • Reverse Flow Workstations
  • Laboratory Incubators
  • CO2 Incubator / Cell Culture Incubator
  • Dual Polarization Interferometer
  • Quartz Crystal Microbalance (QCM)
  • Surface Plasmon Resonance Imaging (SPR Imaging)
  • Blood Chemistry Analyzer / Blood Analyzers
  • Albumin Analyzers (Albumin Testing)
  • Automated Blood Gas Systems
  • Automatic Biochemistry Analyzer / Automated Biochemical Analyzer
  • Blood Bank Automation System / Automated Blood Bank System
  • Blood Gas Analyzers
  • Blood Lactate Analyzer / Blood Lactate Testing Equipment
  • Chemistry Analyzer / Clinical Chemistry Analyzers
  • External Quality Assessment (EQA)
  • HbA1c Analyzer / Haemoglobin Analyzer
  • Haematology Analyzers
  • Haemostasis Analyzer
  • Immunoassay Analyzer
  • Immunoassay System
  • Immunochemistry Analyzer
  • Laboratory Blood Glucose Analyzers
  • Cell Counters / Colony Counters
  • Automated Cell Counter
  • Bacterial Colony Counters
  • Colony Counting Apparatus
  • Disintegration Tester / Disintegration Apparatus
  • Dissolution Apparatus / Dissolution Tester
  • Dissolution Sampler / Dissolution Sampling System
  • Dissolved CO2 Meter / Dissolved Carbon Dioxide Analyzer
  • Cell Disruptor
  • Cell Harvesting System
  • Off-gel Fractionators/ Off-gel Electrophoresis System
  • UV Trans-illuminator
  • CO2 Transmitter / Carbon Dioxide Transmitter
  • Colony Picker
  • ADME-Tox Screening System
  • Amino Acid Analysis System / Amino Acid Analysis Instruments
  • Automated Hit Picking Systems
  • Automated Proteomics Workcell
  • Bio molecular Interaction Analysis
  • Automated Bio molecular Interaction Analyzer
  • Electrophoresis Analysis
  • Capillary Electrophoresis Instrument
  • Digital Gel Photography System / Gel Image Capture System
  • Electrophoresis Power Supply
  • Gel Electrophoresis Instrument
  • Flow Cytometry
  • Automated Flow Cytometry System
  • Flow Cytometer
  • Friability Tester / Friability Test Apparatus
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • Gas Chromatography Equipment
  • Gas Chromatograph / GC System (GC Instruments)
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • GC / GC MS Software
  • GC Auto-sampler / GC Headspace Auto-sampler
  • GC Fraction Collector
  • GC Gas Regulators / High Purity Gas Regulator
  • Multidimensional Gas Chromatography (MDGC / GCxGC)
  • Portable GC MS
  • Glass Bead Autoclave
  • Glass Bead Sterilization / Laboratory Glass Bead Sterilizer
  • Hyper-spectral Image Analysis
  • Chemical Imaging Systems (NIR / Raman)
  • Hyper-spectral Camera / Hyper-spectral Imaging Systems
  • Immuno-blotting Equipment
  • Blot Strip Cutter
  • Cryogenic Refrigerator / Cryofreezer
  • Animal Pulse Oximeters
  • Animal Temperature Probe
  • Animal Ventilator
  • Animal Warmers
  • Cryogenic Refrigerator
  • Animal Pulse Oximeters

Tablet Making Machine India – Cost Price Manual

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Tablet Making Machine

In today’s date “tablets” h0old an essential part of our life.  Most of us consume tablets everyday be it a teenager, middle aged or an old man.  Now consumption of tablets has become a part of our life for most of us if not all.  Looking back at the process of making tablets in the Industry, it is a typical process and passes through certain phases before it is completely done and sealed pack for selling.  Today we will be hereby discussing how tablets making machine is helping to make tablets in short and a precise way.

Tablet Making Machine India – Cost Price Manual

The process

The tablet making machine is generally known as the Tablet Press and consists of two different types mainly.  One is known as the single-punch and another is called the rotary tablet presses.  The punches and dies used for making tablets come in different variety of sizes, shapes, designs and can be easily customized according to need and generally is manufactured with manufacturer codes and scoring lines which makes it more easier for the user to break the tablet at once.  Now depending on the size, shape, material and configuration of the press, the machine (press) can produce from around 250,000 to over 1,000,000 tablets an hour on a general basis as per stats obtained from various production houses.  Now speaking about its mechanism, tablet presses work in a very high speed and takes the form of a rotating turret.  It simply holds number of punches as customized before production.  Once it starts to rotate around the turret, the punches come close in contact with the cams in use and control the punches in a vertical position for the tablets to get manufactured.

The tablet press that we are speaking of here has a simple mechanism to work with.  The main objective of the machine or device is to compresses powder into tablets which comes out in a uniform manner in terms of shape, size and weight as per the requirement of the production house.  The press has got a high potential and generally used to manufacture tablets of different types in conjunction to the variety of materials used.  This can include illicit drugs, pharmaceuticals, cleaning products and cosmetics as well.  The granulated material in order to be given a proper shape into a tablet is firstly metered into a cavity form.  This is done by the use of two punches and a die.  Once this is done, the punches are pressed together with great force.  This in return fuses the materials together giving a shape of a tablet.  For most of the tablet press machines the most integral part of it remains the same ie.  Hopper, Die, Punches, Cam track and feeding mechanism.

Tablet making machine cost manual price

Different types of machine

Now speaking about tablet press and its actions, it is has been found that this tablet making machine comes in two different variants.  One is called the single station or eccentric press and another is the multiple station or popularly known as the rotary tablet press.  The Single station is relatively compact in nature to that of the multiple one and is basically easier to operate among the two in comparison.  It is used to produce chewable tablets, Effervescent and other compressed tablets.  Whereas speaking about the multiple station, its setting up is much more streamlined and can be fined tuned for more customization than that of the two with much higher production rate and obviously the capability of it is immense when compared.  The machine has capability of ejecting, filling and removal of the tablet as well after compression procedure.

Top Pharmaceutical Machinery Manufacturers in India – Pharma Machinery Suppliers

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Pharmaceutical Machinery Manufacturers in India

Pharmaceutical Machinery Manufacturers in India: In today’s world when most of the countries are on the verge of extending their capabilities in each and every spheres of life and implementing new ideas and innovations to satisfy life on a larger scale, India is also on the same track as well.  When pharmaceutical machinery manufacturing in India is concerned, today India is considered to be one of the best in the world and is simply reaching new heights of success on a whole.  Hereby we try to figure out some of the prime manufactures in India who are a leading brand in manufacturing pharmaceutical machinery and about their activities in short.

Pharmaceutical Machinery Manufacturers in India

  • Pharma Tech International

Pharma Tech International is considered to be one of the finest Pharmaceutical machinery manufacturers from India.  The company came into existence in the year 2007 with a current annual turnover of Rs 50 lacks to 1 Crore according to stats obtained from sources.  This company boots itself in producing high profile machines like automatic capping machine, capsule section machinery, ointment section machinery, tablet section machinery, crushing machines, globule making machines and the list goes on.  The products are really durable in nature with capabilities of performing accurately and mostly are fully automatic in nature and require less amount of human interference.

  • Prism Pharma Machinery

Prism Pharma Machinery from the land of Gujarat came into existence in the year 2003.  They provide some of the best durable and highly sophisticated pharmaceutical machinery.  With a reputed base and trust of serving this industry from a long time they boost their capabilities in providing machines like high shear mixer granulation, RMG, Tray dryer, oscillating granulator, bin blender, Tumbler bender, Drum mixer blender, mass mixers and others.  They are best in making Roll compactor, Vibro shifter, basket extruder, movable hoist, automatic tablet coater, colloid mill, capsule polishing machine, sealing machine and the list is endless.

Today they stand as one of the finest in the business and provide some of the best products for pharmaceutical use.

Pharmaceutical Machinery Manufacturers in India

  • Harrison’s Pharma Machinery Pvt. Ltd

This ISO certified company from Delhi since its inception days in the year 1983 have always been in the limelight with the quality of machines they manufacture and have the repute also of providing wide range of products as well.  The list is long and some of the wide variety of products they manufacture includes ointment plant, lami tube filling & sealing machine, stainless steel storage tank, Mini Pulverizer, Cyclone Type Pulverizer, Powder mixer and rotary bottle washing machinery as well.  They also produce some of the finest quality machines in relation to laboratory use, syrup manufacturing, multipurpose equipments and many more.

Top Pharmaceutical Machinery Manufacturers in India – Pharma Machinery Suppliers

  • Lohashilpi

This is another innovative manufacturer from the state of Kerala which is considered to be one of the finest pharmaceutical machinery manufactures in India.  They have a huge number of productivity which includes Liquid filling machines, Semi automatic blister sealing machines, Hydro pneumatic blister trimming machines.  They are capable of providing some of the best quality products available in the market today with capabilities of producing high range products for use.  They also deal in automatic rubber machinery, packaging solutions and manufacturing machines yielding rubber accessories as well.

Given above are some of the finest pharmaceutical machinery manufacturers from India who really have done a great job and helped largely improving the quality of pharmaceutical products on a whole.  There are different other companies as well which do have the similar potentials and produce a great variety and quality machines that not only improve the quality but also improves the volume of manufacturing.

Pharmaceutical Machinery Manufacturers in Mumbai – Pharma Navi Bombay

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pharma machinery manufacturers in navi mumbai

Pharmaceutical Machinery Manufacturers in Mumbai: Today we will be concentrating on some of the best pharmaceutical machine manufacturers from Mumbai, India who have who have constantly given enough effort and hard work to make world class product and compete in the market on a global scenario.  Most of them have years of expertise in this specific field and have managed to earn goodwill in the market by their effort.  Here are few of the most trusted brands from Mumbai who develop and manufacture pharmaceutical machinery.

Pharma machinery manufacturers in navi mumbai

  • Jay Pharma Machinery Equipments

This is one of the most trusted companies that are situated in the heart of Mumbai city, India.  Over the last six years the company has grown from strength to strength increasing the numbers of their clients with good service and maintenance of quality product.  This company has the perfect expertise in manufacturing pharmaceutical machinery like wet mixtures, milling machines, washing system, blender, filter press, Ointment Manufacturing Plant, Inline Homogenizer, pallets, cooting system and the list goes on and on.  Today Jay Pharma Machinery Equipments stands high among its rival companies serving the best out of the best.

  • Bright Pharma Machinery

Situated in Andheri, East Mumbai, Bright Pharma Machinery this company is one of the leading manufacturers of Pharmaceutical machinery along with production of cosmetic, bio product machinery as well.  From 20 years this company has been working in the market with infusing and implementing new ideas for the betterment of the business.  It has expertise in designing and manufacturing machines in relation to ointment/cream manufacturing plant, transfer pump, metering pump, filtration unit, cream manufacturing plant, fluid bed dryer, coating pan, spray coating machine, Vibro shifter, rapid mixer granulator and the list is a long one indeed.  This company over the years has a good repute of producing the best when it comes to business on a whole.

  • Prince Pharma Machinery Bombay

Incorporated in the year 2007 at Mumbai, Prince Pharma Machinery has the perfect expertise in providing impeccable quality of pharmaceutical machinery that are of world class standards.  Since its establishment, the company has paved itself to the top with a team of members who have a vision to think big and innovative in the field of pharmaceuticals.  Today they have an arsenal of some of the best machinery which includes manufacturing of fluid bed dryer, Vibro shifter, Mutlil mill, coating machine, starch paste kettle, Zero hold up filter press, tray dryer, Octagonal blender and much more.  This manufacturing unit is considered to be one of the finest in the business today.

pharma machinery manufacturers in navi mumbai

  • Mec Well Pharma Machinery Company – Mumbai

From Thane, Maharashtra Mec Well Pharma Machinery has the perfect capabilities and adequate infrastructure to design and develop some of the most needed pharmaceutical machinery that are of high quality and capable of producing volume productivity.  The company boost itself with manufacture of highly efficient machinery like blending machine, fluid bed dryers, Vibro shifter, blending vessel, liquid manufacturing plant, ointment plant, Ointment Manufacturing Plant, Pharmaceuticals Processing Plant, oral liquid manufacturing plant, pharmaceutical ovens, fermentation tank and the list is endless.  This company today stands as one of the finest manufacturing company and have been serving clients globally with trust and quality.  They have successfully marketed themselves with hard and dedication as one of the best in the business

There are other companies too like Chamunda Pharma Machinery Pvt. Ltd, Harish Pharma Engineeringm Pharma Fab Industries, S K Pharma Machinery Private Limited, Champion Pharma Machines and etc. from Mumbai who are considered to be equally capable, well trusted and rewound when it comes to manufacturing of Pharmaceutical machinery in Mumbai, Maharashtra.

Pharmaceutical Packaging Machinery – Medicines Packing Equipment Types

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Pharmaceutical Packaging Machinery - Medicines Packing Equipment Types

Pharmaceutical Packaging Machinery: In today’s date Pharmaceutical packing machinery hold a very important position when it comes to doing business with the same.  As we all known good packaging not only increased the overall quality appearance of the product but also helps it to do a good branding and provide successful business also.  Today there are different companies who are specialized in this field of work.  They solely work on packing and distributing pharmaceutical packaging.  There are different types of machinery which are uses in this case.  The list is pretty long and most of them are complex in nature whereas there are also simple machinery as well.  Today we are going to discuss about few of the most important Pharmaceutical packaging machinery in short and their use.

Pharmaceutical Packaging Machinery – Medicines Packing Equipment Types

One of the most well known Pharmaceutical packaging machines used very often is Blister Packing Machine.  It is available both for large and small batches of drug processing expediting marketability of Pharma products via blister packing.  Next there is the Pharmaceutical Automatic Capping Machine.  It is used for capping of the pharmaceutical products and is considered to be one of the final steps of ensuring the quality of the product as well.  Next is the Pharmaceutical Filling Machine which simply expedites the current process of packaging.  This filling machine perfectly works for large scale filling used to measure sterility and dispensing of correct volume when in use.  One of the most well-known and widely used machines is Pharmaceutical Ampoule Filling Machine.  This machine is a very complex one and works on a very sophisticated or delicate procedure.  These types of machinery are basically used for pharmaceutical ampoule filling equipment.  The process is a fully automated one and works on a constant basis to provide the required result.  It provides the option of weight checking of product and as well as laser sealing as well.  Another one of the important packaging machinery used for pharmaceutical products is Pharmaceutical Liquid Filling Machine.  It is used for manufacturing of liquid drug suspensions.  This packaging machine is used in variety of forms and use.  It comes in both small and large size.  The operation involves filling of liquid.

Medicines Packing Equipment Types

Now pharmaceutical packaging machinery comes in different price range and in different shapes and sizes.  There are different companies who are best at making these types of machinery.  Some of them are small and some are big production houses.  These production houses basically deal in making pharmaceutical packaging machinery that are all in compliance with FDA standards and maintain a strict protocol as per general guidelines.  Some are semi automatic in nature, some are fully automatic.  When we speak about these type of Pharmaceutical packaging machinery there are different vendor who have earned a good name in the market over the years and have provided world class quality products on a regular basis.  Some of them are Marchesini Group with its headquarters at Italy.  Then there is Mg2 as well from Italy along with Multivac Sepp Haggenmuller.  Bosch and Romaco are two of the most important names that we can add to this list as well and both are from Germany who have the repute of consistently providing quality machinery in this field as well.

Pharmaceutical Packaging Machinery - Medicines Packing Equipment Types

Coming to the concluding part of this discussion, it has been found that these packaging machinery are a very important part of the production of the pharmaceutical products worldwide and provides safety to the finish products as well.  Proper packaging not only ensures the safety of the product but also maintains a proper hygiene to the pharmaceutical products as well which is essential.