What are Non Patentable Inventions? Types & Examples

THE PATENTS ACT, 1970 is an Act to amend and consolidate the law relating to patents.

INVENTIONS NOT PATENTABLE

What are not inventions.
The following are not inventions within the meaning of this
Act,—
(a) an invention which is frivolous or which claims anything obviously contrary to well established natural laws;
(b) an invention the primary or intended use or commercial exploitation of which could be contrary public order or morality or which causes serious prejudice to human, animal or
plant life or health or to the environment;
(c) the mere discovery of a scientific principle or the formulation of an abstract theory or discovery of any living thing or non-living substance occurring in nature;
(d) the mere discovery of a new form of a known substance which does not result in the enhancement of the known efficacy of that substance or the mere discovery of any new property or new use for a known substance or of the mere use of a known process, machine or apparatus unless such known process results in a new product or employs at least one new reactant.
Explanation.—For the purposes of this clause, salts, esters, ethers, polymorphs,metabolites, pure form, particle size, isomers, mixtures of isomers, complexes, combinations and other derivatives of known substance shall be considered to be the same substance, unless they differ significantly in properties with regard to efficacy;
(e) a substance obtained by a mere admixture resulting only in the aggregation of the properties of the components thereof or a process for producing such substance;
(f) the mere arrangement or re-arrangement or duplication of known devices each functioning independently of one another in a known way;
(g) Omitted by the Patents (Amendment) Act, 2002
(h) a method of agriculture or horticulture;
(i) any process for the medicinal, surgical, curative, prophylactic diagnostic, therapeutic or other treatment of human beings or any process for a similar treatment of animals to render them free of disease or to increase their economic value or that of their products.
(j) plants and animals in whole or any part thereof other than micro organisms but including seeds, varieties and species and essentially biological processes for production or propagation of plants and animals;
(k) a mathematical or business method or a computer programme per se or algorithms;
(l) a literary, dramatic, musical or artistic work or any other aesthetic creation whatsoever including cinematographic works and television productions;
(m) a mere scheme or rule or method of performing mental act or method of playing game;
(n) a presentation of information;
(o) topography of integrated circuits;
(p) an invention which in effect, is traditional knowledge or which is an aggregation or duplication of known properties of traditionally known component or components.
4. Inventions relating to atomic energy not patentable.—No patent shall be granted in respect of an invention relating to atomic energy falling within sub section (1) of section 20 of the
Atomic Energy Act, 1962 (33 of 1962).
5. Inventions where only methods or processes of manufacture patentable: [Omitted by the Patents (Amendment) Act, 2005]

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[C program code] Demonstration of Backslash Characters or Escape sequences

Demonstration of Backslash Characters or Escape sequences

First year of B- Pharmacy has a subject Remedial Maths & Computers in which C language is the important topic. This is one of the important questions of it “[C program code] Demonstration of Backslash Characters or Escape sequences”

Backslash or escape characters

 

/*Demonstration of Backslash Characters or
Escape sequences
*/
#include<stdio.h>
main  ()
{int i;
clrscr();
printf(“this is formfeed\t\t Example\f  (\\f)\n”);
getch();
printf(“this is audible alert\t\t Example\a  (\\a)\n”);
getch();
printf(“this is Backspace\t\t Example\b  (\\b)\n”);
getch();
printf(“this is NULL\t\t Exam\n\0ple (\\0)\n”);
getch();
printf(“this is newline\t\t \n Example (\\n)\n”);
getch();
printf(“this is horizontal tab\t\t Exam\tple  (\\t)\n”);
getch();
printf(“this is Vertical tab\t\t Example\v  (\\v)\n”);
getch();
printf(“this is formfeed\t\t Example\f  (\\f)\n”);
getch();
printf(“this is carriage return\t\t \rExample(\\r)”);
getch();
}

[/code]

Demonstration of Backslash Characters or Escape sequences

🤦‍♀️3rd B-PHARM D- Pharm Juris Notes=Narcotic Drugs & Psychotropic Act,1985

3rd B-PHARM Notes

3rd B-PHARM Notes for Pharmaceutical Jurisprudence on Narcotic Drugs and Psychotropic Substances Act,1985 and Rules, 1985

Narcotic drugs and psychotropic substances are the habit forming substances which may produce a sleep. At higher concentration, those substances proved to be toxic and therefore, there is a restriction for the cultivation, collection, import, manufacture, purchase, sale, transportation of narcotic drugs and psychotropic substances. Psychotropic substances are substance, salt or any preparation which is included in the list of narcotic substance as specified in the Schedules to the Act.

Cannabis

Charas :

separated resin whether crude or purified obtained from Cannabis plant and also includes concentrated preparations and resin known as hashish oil or liquid hashish.

Ganja:

Flowering and fruiting tops of Cannabis plant excluding from seeds and leaves, or

Any mixture with or without neutral material of any above forms of Cannabis or any drink prepared from them.

Coca derivatives:

Crude cocaine which can be used directly or indirectly for the manufacture of cocaine; or

  1. b) Ecgonine and all the derivatives of ecgonine from which it can be recovered; or
  2. c) Cocaine i.e. methyl ester of benzoyl ecgonine; or
  3. d) All the preparations containing more than 0.1% cocaine
  4. 3rd B-PHARM Notes

Opium poppy

The plant of species Papaver somniferum or the plant of any other species of Papaver from which opium or any other phenanthrene alkaloids can be extracted and Central Government may declare to be Opium poppy.

Poppy straw

Parts of Opium poppy after harvesting them in their original form, cut or rushed and whether or not the juice has been extracted therefrom.

Poppy straw concentrate

Material arising when the poppy straw has entered into processes for the concentration of its alkaloids

Coca Leaf

Leaf of coca plant except a leaf from which cocaine and all the derivatives of ecgonine have been removed and any mixture with or without neutral material but does not include any preparation containing not more than 0.1% cocaine.

Coca Plant

Plant of any species of the genus Erythroxylon.

Medicinal Cannabis (hemp) is Extract or tincture of Cannabis (hemp).

Prepared opium

Opium which is obtained by any series of operations design to transform opium into an extract suitable for smoking and the dross or other residue remaining after the opium is being smoked.

Medicinal opium

Opium which has undergone the processes necessary to adopt it for its medicinal use in accordance with the requirements of Indian Pharmacopoeia or any other Pharmacopoeia notified, whether in powder form or granulated or mixed with the neutral material.

*only for educational purpose

Dry Granulation – STEPS METHOD USES PPT PDF

Dry Granulation

Dry granulation is a powder agglomeration process used in the pharmaceutical industry to improve the flowability of powders by increasing the particle size (granules). This operation is achieved using a roller press, which can have different configurations and equipment designs.
In simple terms Granulation is the process in which primary powder particles are made to adhere to form larger multiparticle entities called granules.

Dry granulation Roller compactor

Dry Granulation Advantages & Limitations:

(Slugging of rollercompaction)
Advantages:
* Eliminates exposure to moisture and drying.
* Dusty procedure.

This is also called double compression or slugging method, this is valuable alternative to direct compression,
where the dose of drug is too high or to wet granulation when the drug is sensitive to heat, moisture or both.
This method is also used when other methods of granulation yield granules with poor flow or compression
properties, because there are less chances of segregation of drug and excipients.

Limitations:
* Not suitable for all compounds.
* Slow process.

Long processing time, a relatively high capital investment on heavy duty presses or compactors.

 

Steps involved in dry granulation process

I. Milling of drugs and excipients
II. Mixing of milled powders
III. Compression into large, hard tablets to make slug
IV. Screening of slugs
V. Mixing with lubricant and disintegrating agent
VI. Tablet compression

 

In dry granulation method the primary powder particles are aggregated at high pressure. There are two main processes – either a large tablet (known as slug) is produced in a heavy duty tableting press( known as slugging) or the powder is squeezed between two rollers to produce a sheet of material (roller compaction) . The two different types are illustrated in below:

Slugging process

how well a material may slug will depend on the below terms

  1. Compressibility or cohesiveness of the matter,
  2. Compression ratio of powder
  3. Density of the powder
  4. Machine type
  5. Punch and die size
  6. Slug thickness
  7. Speed of compression
  8. Pressure used to produce slug

Granulation by slugging is the process of compressing dry powder of tablet formulation with tablet press having die cavity large enough in diameter to fill quickly. The accuracy or condition of slug is not too important. Only sufficient pressure to compact the powder into uniform slugs should be used. Once slugs are produced they are reduced to appropriate granule size for final compression by screening and milling

Slugging (Old Method)Slugging (Old Method) • material to be granulized is first made into a large compressed mass or “slug” typically by way of a tablet press using large flat-faced too long.

Disadvantages of Slugging:

  1. single batch processing
  2. frequent maintenance changeover
  3. poor process control
  4. poor economies of scale
  5. low manufacturing output per hour
  6. excessive air and sound pollution,
  7. Increased use of storage containers,
  8. more energy and time required to produce

Roller compaction:

In a roller compactor material particles are consolidated and densified by passing the material between two high-pressure rollers. The densified material from a roller compactor is then reduced to a uniform granule size by milling.
Roller compaction dry granulation process is capable of handling a large amount of material in a short period of time. As a special subtype briquetting utilizes special designed compaction rolls which divides the compacted powder in pieces (briquettes).
For dry granulation the compaction force in extend and uniformity of distribution is essential in regard to uniformity of granules porosity to ensure uniform hardness and disintegration of the final product. Because of its advantages, roll compaction is being increasingly used as a granulation technique, but it is not a simple process and may involve many variables for example roll pressure, roll speed, horizontal/vertical feed screw speed, roller gap, screen size. These parameters need to be optimized depending on the materials and the type of equipment used in order to obtain products of desirable quality.

Pneumatic Dry Granulation:

The pneumatic dry granulation process is a new and patent pending technology. The granulation process is based on the
use of roller compaction with very low compaction force together with a proprietary air classification method. The method enables production of granules with extraordinary combination of flow ability and compressibility. The granules produced by Pneumatic Dry Granulation and tablets produced show fast disintegration properties, offering the potential for fast
release dosage forms, and Release time can be tailored to requirements.
PDG technology can achieve, high drug loading, even with difficult APIs and combinations along with Taste masking and Excellent stability

 

References:

  1. Ankit Sharma, Pooja sethi, Dinesh pawar. “Granulation techniques and innovations”, Inventi Rapid: Pharmtech, Vol.10, 2011
  2. Himanshu.K.Solanki, Tarashankar Basuri, Jalaram H.Thakkar, “Recent advances in granulation technology, International Journal of Pharmaceutical Sciences Review and Research, 3(5), 48,2010 . 11.
  3. Nidhi Prakash Sapkal, Vaishali A. Kilor, Minal Nandkumar Bonde. Application of a convenient and cost and effective granulation technology for the formulation of tablets using conventional excipients, Asian Journal of Pharmaceutics – 225-254, 2014.
  4. Rudnic EM, Schwartz JD. Oral solid dosage forms In: Remington: The science and practice of pharmacy Gennaro, Lippincott Williams and Wilkins, USA, 2000: 858.
  5. Gohel MC. A review of co-processed directly compressible excipients. J Pharm Pharmaceut Sci 2005; 8: 76-93.
  6. Schwartz JB, Fonner DE, Anderson NR, Banker GS. Granulation and tablet characteristics, Lieberman HA, Lachman L, eds. Pharmaceutical Dosage Forms: Tablets. Vol. 2, New York, Marcel Dekker, 1981:201.

Oxytocin: Functions Drugs Side Effects Contraindications Pharmacokinetics Dynamics

Oxytocin: Functions Drugs Side Effects Contraindications Pharmacokinetics Dynamics

Oxytocin is a hormone, predominately belonging to mammalian family; it is secreted by the posterior pituitary gland. After its release in the blood stream it cannot re-enter the brain due to the presence of blood brain barrier .Oxytocin is a hormone that has both peripheral and central actions. y are synthesized in the magnocellular neurons present in the supra–optic and Para –ventricular nucleus present in the hypothalamus. The universally known functions would include its role at the time of labour and ejection of milk. The functions which remain partially unknown are in erectile responses, ejaculation, bonding, and feeling of love and maintenance of eye contact during a conversation. 

Functions and roles of Oxytocin:

Oxytocin plays a key role in establishing trust , falling in love , parturition , milk ejection, mother – child bond , erection and ejaculatory response in males. Oxytocin insuffiency is leads to increased stress and sleep disturbances. The solution to the above mentioned problem lies in creating a drug which can mimic the functional properties of Oxytocin, which was achieved. Oxytocin has been widely used in the field of gynaecology to induce labour. It is also administered to patients i.e. mothers who are unable to produce milk after parturition. The invention of Oxytocin nasal sprays is not unknown. Recommended doses when administered to autism patients are proven to increase the sense of trust at the time of communication.

Mechanism of OXYTOCIN

Oxytocin is a naturally occurring nonapeptide hormone which acts through a G-protein coupled cell surface receptor to stimulate contractions of the uterus. A synthetic version of this hormone is used to induce contractions of the uterus which are indistinguishable from spontaneous labour.

Pharmacokinetics

Oxytocin is administered as a slow intravenous infusion (to induce or augment labour), or as a single intramuscular or intravenous injection to help prevent and treat uterine atony and postpartum haemorrhage. In pregnant women, oxytocin is metabolised very quickly in the maternal circulation by an aminopeptidase enzyme which cleaves the protein leaving it without biological function. This oxytocinase activity is also seen within the placenta and uterine tissue, and activity increases throughout pregnancy where at term the half -life of oxytocin is between 2 and 20 minutes.

Oxytocin: Functions Drugs Side Effects Contraindications Pharmacokinetics Dynamics

Adverse effects

The main side effects are related to overstimulation of the uterus which can compromise the placental blood supply and fetal well-being, and can also contribute to rupture of the uterus especially in women who have had a previous caesarean delivery. Oxytocin is similar in structure to Vasopressin which is also produced by the posterior pituitary, and prolonged administration with intravenous fluids may lead to fluid overload, pulmonary oedema and water intoxication.

Oxytocin Molecular Formula

It has a molecular formula of C43H66N12O12S 2.

Oxytocin drugs:

Oxytocin is also known as Pitocin, Syntocinon, Ocytocin, Endopituitrina, Oxitocina, Oxytocine, Oxytocinum, Oxytocic hormone and Orasthin.

It has a molecular formula of C43H66N12O12S 2. They are commercially available as intravenous and intramuscular injections , nasal sprays and sublingual tablets .The commonly used Anirudha kabilan /J. Pharm. Sci. & Res. Vol. 6(4), 2014, 220-223 221 drug types are pitocin and syntocinon, the chemical resemblance to Oxytocin makes them an ideal drug of choice for various cases for example at time if parturition . Pitocin is composed of oxtocic acid/ml along with chlorobutanol , a chloroform derivative. However medical supervision is mandatory to rule out the onset of complications (20,31). The general uses of these Oxytocin drugs would include induction of labour .Under appropriate level , at the time delivery, Oxytocin binds to the receptors present in the myometrium , activates the pathway of hydrolysis of phoshotidyl inositol and diacyl glycerol, there by activating the same. This activation causes the release of intracellular Ca+ which causes contraction of the uterus .In conditions associated with low level of Oxytocin production this process is carried out by Oxytocin drugs (29, 27) Incase of people suffering from autism, administration of pitocin is said to reduce repetitive behaviour and also enhances speech. Few researches have proved the improvement of trust in people affected by autism when they were given pitocin nasal sprays. It also enhances eye to eye contact in these individuals. Pitcoin helps in social interaction in people who suffer from schizophrenia . So pitocin may not only combat hallucinogens and psychosis, but also make human interaction easier . Being a new field if research there is not enough evidence to prove the role pitocin in both autism and schizophrenia. Further, they are also used to cure problems in erectile responses, ejaculation, depression, anxiety, and stress management

Dosage of Oxytocin:

10 units by intravenous route or 20-40 mUnit/min by Intramuscular route are injected for post partum haemorrhage. 0.5-1 mUnit/min by intravenous route for the induction of labour.10-20 mUnit/min is administered along with other drugs for termination of pregnancy.

Pharmacodynamics

Uterine contractions are seen after 3-5 minutes and approx 1 minute of aministration through intramuscular and intravenous routes respectively. A steady state of the drug is reached after 40 mins of parenteral route of administration. It is distributed throughout extracellular fluid compartment of the mother; small amounts may cross the placental barrier and reach foetus. Metabolism takes place rapidly via the liver and plasma by the enzyme oxytocinase a few steps of metabolism also takes place via mammary gland. It has a half-life of 1-5 minute. Kidney and liver help in the elimination of Oxytocin drugs( 9) unchanged form of this drug is rarely excreted in urine (30). Overdose can cause titanic uterine contractions, impaired blood flow to the uterus, uterine ruptures, seizures and amniotic fluid embolism contractions, impaired blood flow to the uterus, uterine ruptures, seizures and amniotic fluid embolism.

Contraindications:

Significant cephalopelvic disproportion
Unfavourable foetal positions
Obstetric emergencies which favours surgery
Hyperactive or hypertonic uterus
When vaginal delivery is contraindicated,
Anaphylactic patients, Foetal distress
Polyhydramnios
Partial placenta pervia
Elective labour induction

Side effects

 Nausea or vomiting
 Memory problems or confusion
 Runny nose, sore throat, or coughing
 severe headaches
 hallucinations
 vomiting
 confusion
 Seizures and severe hypertension

Clinical Scenario 1

 Which of the following abnormalities of labor is associated with a significantly increased incidence of neonatal
morbidity?
a. Prolonged latent phase
b. Protracted descent
c. Secondary arrest of dilation
d. Protracted active-phase dilation
Answer: c (Secondary arrest of dilation)
Explanation:
Three significant advances in the treatment of uterine dysfunction have reduced the risk of perinatal morbidity (PNM) and
mortality: (1) the avoidance of undue prolongation of labor, (2) the use of intravenous oxytocin in the treatment of some patterns
of uterine dysfunction, and (3) the liberal use of cesarean section (rather than midforceps) to affect delivery when oxytocin fails.

Clinical Scenario 2

Management of obstructed labor includes all, except:
[AIIMS May 2004]
a. IV fluids
b. Oxytocin use
c. Antibiotics
d. Cesarean section
Answer: b (Oxytocin use)
Explanation:
Two main principles in management of obstructed labor are:
1. Never wait and watch.
2. Never use oxytocin.
In patients of obstructed labor, the uterine contractions (power) are always adequate.
There is a problem with the passage or the passenger.
By increasing the power (by giving oxytocin) we are increasing the risk of rupture uterus.
It is like flogging a dead horse. Uterus is already contracting, and there is no point in increasing the contractions further in
a case of obstructed labor.
The patient should be given IV fluids to correct the dehydration and ketoacidosis, which usually develops due to prolonged
labor. Patient should be given antibiotics to prevent infection, and then steps should be taken to immediately relieve
the obstruction either by instrumental deliver or by LSCS. LSCS may have to be done even if the baby is dead and if vaginal
delivery is not possible, or else rupture uterus will occur.
NOTE: In cases of prolonged labor where there are hypotonic uterine contractions, oxytocin is justified.

LABELING -Pharmaceutical Labeling Requirements Theory PPT PDF

LABELING -Pharmaceutical Labeling Requirements Theory PPT PDF

Labeling:

The term “labeling” designates all labels and other written, printed, or graphic matter upon an immediate container of an article or upon, or in, any package or wrapper in which it is enclosed, except any outer shipping container.

Labeling?

The term “label” designates that part of the labeling upon the immediate container. A shipping container containing a single article, unless such container is also essentially the immediate container or the outside of the consumer package, is labeled with a minimum of product identification (except for controlled articles), lot number, expiration date, and conditions for storage and distribution. Articles in these compendia are subject to compliance with such labeling requirements as may be promulgated by governmental bodies in addition to the compendial requirements set forth for the articles.

Label: Amount of Ingredient Per Dosage Unit:

The strength of a drug product is expressed on the container label in terms of micrograms or milligrams or grams or percentage of the therapeutically active moiety or drug substance, whichever form is used in the title, unless otherwise indicated in an individual monograph. Both the active moiety and drug substance names and their equivalent amounts are then provided in the labeling. Official articles in capsule, tablet, or other unit dosage form shall be labeled to express the quantity of each active ingredient or recognized nutrient contained in each such unit; except that, in the case of unit-dose oral solutions or suspensions, whether supplied as liquid preparations or as liquid preparations that are constituted from solids upon addition of a designated volume of a specific diluent, the label shall express the quantity of each active ingredient or recognized nutrient delivered under the conditions prescribed in Deliverable Volume 〈698〉. Official drug products not in unit dosage form shall be labeled to express the quantity of each active ingredient in each milliliter or in each gram, or to express the percentage of each such ingredient (see 8.140., Percentage Concentrations), except that oral liquids or solids intended to be constituted to yield oral liquids may, alternatively, be labeled in terms of each 5-mL portion of the liquid or resulting liquid. Unless otherwise indicated in a monograph or chapter, such declarations of strength or quantity shall be stated only in metric units. 

Labeling: Use of Leading and Terminal Zeros

To help minimize the possibility of errors in the dispensing and administration of drugs, the quantity of active ingredient when expressed in whole numbers shall be shown without a decimal point that is followed by a terminal zero (e.g., express as 4 mg [not 4.0 mg]). The quantity of active ingredient when expressed as a decimal number smaller than 1 shall be shown with a zero preceding the decimal point (e.g., express as 0.2 mg [not .2 mg]).

Labeling of Salts of Drugs

It is an established principle that official articles shall have only one official title. For purposes of saving space on labels, and because chemical symbols for the most common inorganic salts of drugs are well known to practitioners as synonymous with the written forms, the following alternatives are permitted in labeling official articles that are salts: HCl for hydrochloride; HBr for hydrobromide; Na for sodium; and K for potassium. The symbols Na and K are intended for use in abbreviating names of the salts of organic acids, but these symbols are not used where the word Sodium or Potassium appears at the beginning of an official title (e.g., Phenobarbital Na is acceptable, but Na Salicylate is not to be written).

Labeling Vitamin-Containing Products

LABELING -Pharmaceutical Labeling Requirements Theory PPT PDF
The vitamin content of an official drug product shall be stated on the label in metric units per dosage unit. The amounts of vitamins A, D, and E may be stated also in USP Units. Quantities of vitamin A declared in metric units refer to the equivalent amounts of retinol (vitamin A alcohol). The label of a nutritional supplement shall bear an identifying lot number, control number, or batch number. 10.40.50. Labeling Botanical-Containing Products The label of an herb or other botanical intended for use as a dietary supplement bears the statement, “If you are pregnant or nursing a baby, seek the advice of a health professional before using this

Labeling Parenteral and Topical Preparations

The label of a preparation intended for parenteral or topical use states the names of all added substances (see 5.20., Added Substances, Excipients, and Ingredients and see Labeling under Injections 〈1〉), and, in the case of parenteral preparations, also their amounts or proportions, except that for substances added for adjustment of pH or to achieve isotonicity, the label may indicate only their presence and the reason for their addition.

Labeling Electrolytes:

The concentration and dosage of electrolytes for replacement therapy (e.g., sodium chloride or potassium chloride) shall be stated on the label in milliequivalents (mEq). The label of the product shall indicate also the quantity of ingredient(s) in terms of weight or percentage concentration.

Labeling Alcohol:

The content of alcohol in a liquid preparation shall be stated on the label as a percentage (v/v) of C2H5OH.

Symbols Commonly Employed for SI Metric Unit

Symbols commonly employed for SI metric units and other units
are as follows:
Bq = becquerel dL = deciliter
kBq = kilobecquerel L = liter
MBq = megabecquerel mL = milliliterc
GBq = gigabecquerel μL = microliter
Ci = curie Eq = gram-equivalent weight
mCi = millicurie mEq = milliequivalent
μCi = microcurie mol = gram-molecular weight (mole)
nCi = nanocurie Da = dalton (relative molecular mass)
Gy = gray mmol = millimole
mGy = milligray Osmol = osmole
m = meter mOsmol = milliosmole
dm = decimeter Hz = hertz
cm = centimeter kHz = kilohertz
mm = millimeter MHz = megahertz
μm = micrometer (0.001mm) V = volts
nm = nanometera MeV = million electron volts
kg = kilogram keV = kilo-electron volt
g = gram mV = millivolt
mg = milligram psi = pounds per square inch
μg; mcg = microgramb Pa = pascal
ng = nanogram kPa = kilopascal
pg = pictogram g = gravity (in centrifugation)
fg = femtogram
a Previously the symbol mμ (for millimicron) was used.
b One milliliter (mL) is used herein as the equivalent of one cubic centimeter (cc).
c The symbol μg is used in the USP and NF to represent micrograms, but micrograms
may be represented as “mcg” for labeling and prescribing purposes. The term
“gamma,” symbolized by γ, frequently is used to represent micrograms in biochemical
literature

Pharmacology MCQ for NEET PG GPAT PHARMACIST Nursing Questions with Answers pdf Book

Pharmacology MCQ for NEET PG GPAT PHARMACIST Nursing Questions with Answers pdf Book

Today Pharmawiki is here with very important 40+ Pharmacology multiple choice questions along with answers. These are published especially for all our pharmacy students who are ready to take up different competitive exams like NEET PG GPAT PHARMACIST qualifying examinations. These questions are also very helpful to all the students and professionals of Nursing to take up different examinations for their career growth. This article specifically provides questions with answers pdf Book at the end for our readers convenience. You can click on the right side and download the entire copy to study easily. 

Pharmacology MCQ for Anti Cancer Chemotherapy Drugs

ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER

All of the following antiviral drugs are the analogs of nucleosides, EXCEPT:

a) Acyclovir

b) Zidovudine

c) Saquinavir

d) Didanozine

Tick the drug, a derivative of adamantane:

a) Didanozine

b) Rimantadine

c) Gancyclovir

d) Foscarnet

Tick the drug, a derivative of pyrophosphate:

a) Foscarnet

b) Zidovudine

c) Vidarabine

d) Acyclovir

Tick the drug, inhibiting viral DNA synthesis:

a) Interferon

b) Saquinavir

c) Amantadine

d) Acyclovir

Tick the drug, inhibiting uncoating of the viral RNA:

a) Vidarabine

b) Rimantadine

c) Acyclovir

d) Didanozine

Tick the drug, inhibiting viral reverse transcriptase:

a) Zidovudine

b) Vidarabine

c) Rimantadine

d) Gancyclovir

Tick the drug, inhibiting viral proteases:

a) Rimantadine

b) Acyclovir

c) Saquinavir

d) Zalcitabine

Tick the drug of choice for herpes and cytomegalovirus infection treatment:

a) Saquinavir

b) Interferon alfa

c) Didanozine

d) Acyclovir

136

Tick the drug which belongs to nonnucleoside reverse transcriptase inhibitors:

a) Zidovudine

b) Vidarabine

c) Nevirapine

d) Gancyclovir

All of the following antiviral drugs are antiretroviral agents, EXCEPT:

a) Acyclovir

b) Zidovudine

c) Zalcitabine

d) Didanozine

Tick the drug used for influenza A prevention:

a) Acyclovir

b) Rimantadine

c) Saquinavir

d) Foscarnet

Tick the drug used for HIV infection treatment, a derivative of nucleosides:

a) Acyclovir

b) Zidovudine

c) Gancyclovir

d) Trifluridine

Tick the antiviral drug which belongs to endogenous proteins:

a) Amantadine

b) Saquinavir

c) Interferon alfa

d) Pencyclovir

Tick the drug which belongs to nucleoside reverse transcriptase inhibitors:

a) Didanosine

b) Gancyclovir

c) Nevirapine

d) Vidarabine

All of the following antiviral drugs are anti-influenza agents, EXCEPT:

a) Acyclovir

b) Amantadine

c) Interferons

d) Rimantadine

Pharmacology MCQ for NEET PG GPAT PHARMACIST Nursing Questions with Answers pdf Book

Tick the unwanted effects of zidovudine:

a) Hallucinations, dizziness

b) Anemia, neutropenia, nausea, insomnia

c) Hypertension, vomiting

d) Peripheral neuropathy

Tick the unwanted effects of intravenous acyclovir infusion:

a) Renal insufficiency, tremors, delerium

b) Rash, diarrhea, nausea

c) Neuropathy, abdominal pain

d) Anemia, neutropenia, nausea, insomnia

Tick the drug that can induce peripheral neuropathy and oral ulceration:

a) Acyclovire

b) Zalcitabine

c) Zidovudine

d) Saquinavir

Tick the unwanted effects of didanozine:

a) Hallucinations, dizziness, insomnia

b) Anemia, neutropenia, nausea

c) Hypertension, vomiting, diarrhea

d) Peripheral neuropathy, pancreatitis, diarrhea, hyperuricemia

Tick the unwanted effects of indinavir:

a) Hypotension, vomiting, dizziness

b) Nephrolithiasis, nausea, hepatotoxicity

c) Peripheral neuropathy, pancreatitis, hyperuricemia

d) Anemia, neutropenia, nausea

Tick the drug that can induce nausea, diarrhea, abdominal pain and rhinitis:

137

a) Acyclovire

b) Zalcitabine

c) Zidovudine

d) Saquinavir

All of the following effects are disadvantages of anticancer drugs, EXCEPT:

a) Low selectivity to cancer cells

b) Depression of bone marrow

c) Depression of angiogenesis

d) Depression of immune system

Rational combination of anticancer drugs is used to:

a) Provide synergism resulting from the use of anticancer drugs with different mechanisms combination

b) Provide synergism resulting from the use of anticancer drugs with the same mechanisms combination

c) Provide stimulation of immune system

d) Provide stimulation of cell proliferation

Tick the anticancer alkylating drug, a derivative of chloroethylamine:

a) Methotrexate

b) Cisplatin

c) Cyclophosphamide

d) Carmustine

Tick the anticancer alkylating drug, a derivative of ethylenimine:

a) Mercaptopurine

b) Thiotepa

c) Chlorambucil

d) Procarbazine

Tick the group of hormonal drugs used for cancer treatment:

a) Mineralocorticoids and glucocorticoids

b) Glucocorticoids and gonadal hormones

c) Gonadal hormones and somatotropin

d) Insulin

Tick the anticancer alkylating drug, a derivative of alkylsulfonate:

a) Fluorouracil

b) Carboplatin

c) Vinblastine

d) Busulfan

Tick the anticancer drug of plant origin:

a) Dactinomycin

b) Vincristine

c) Methotrexate

d) Procarbazine

Action mechanism of alkylating agents is:

a) Producing carbonium ions altering protein structure

b) Producing carbonium ions altering DNA structure

c) Structural antagonism against purine and pyrimidine

d) Inhibition of DNA-dependent RNA synthesis

Tick the anticancer drug, a pyrimidine antagonist:

a) Fluorouracil

b) Mercaptopurine

c) Thioguanine

d) Methotrexate

Methotrexate is:

a) A purine antagonist

b) A folic acid antagonist

c) An antibiotic

d) An alkylating agent

Tick the antibiotic for cancer chemotherapy:

a) Cytarabine

b) Doxorubicin

c) Gentamycin

d) Etoposide

Fluorouracil belongs to:

a) Antibiotics

b) Antimetabolites

c) Plant alkaloids

d) Bone marrow growth factor

Tick the action mechanism of anticancer drugs belonging to plant alkaloids:

a) Inhibition of DNA-dependent RNA synthesis

b) Cross-linking of DNA

c) Mitotic arrest at a metaphase

d) Nonselective inhibition of aromatases

ANTIVIRAL AGENTS. AGENTS FOR CHEMOTHERAPY OF CANCER

General contraindications for anticancer drugs are:

a) Depression of bone marrow

b) Acute infections

c) Severe hepatic and/or renal insufficiency

d) All of the above

Action mechanism of methotrexate is:

a) Inhibition of dihydrofolate reductase

b) Activation of cell differentiation

c) Catabolic depletion of serum asparagine

d) All of the above

Tick the anticancer drug belonging to inorganic metal complexes:

a) Dacarbazine

b) Cisplatin

c) Methotrexate

d) Vincristine

Tick the indication for estrogens in oncological practice:

a) Leukemia

b) Cancer of prostate

c) Endometrial cancer

d) Brain tumors

Enzyme drug used for acute leukemia treatment:

a) Dihydrofolate reductase

b) Asparaginase

c) Aromatase

d) DNA gyrase

All of the following drugs are derivatives of nitrosoureas, EXCEPT:

a) Carmustine

b) Vincristine

c) Lomustine

d) Semustine

Tick the group of drugs used as subsidiary medicines in cancer treatment:

a) Cytoprotectors

b) Bone marrow growth factors

c) Antimetastatic agents

d) All of the above

Tick the estrogen inhibitor:

a) Leuprolide

b) Tamoxifen

c) Flutamide

d) Anastrozole

Tick the antiandrogen drug:

a) Flutamide

b) Aminoglutethimide

c) Tamoxifen

d) Testosterone

Tick the drug belonging to aromatase inhibitors:

a) Octreotide

b) Anastrozole

c) Flutamide

d) Tamoxifen

Tick the drug belonging to gonadotropin-releasing hormone agonists:

a) Leuprolide

b) Tamoxifen

c) Flutamide

d) Anastrozole

Pharmacology MCQ for Anti Cancer Chemotherapy Drugs

Pharmacology MCQ for Anti Cancer Chemotherapy Drugs

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Pharmacodynamics – Dose Response relationship- Terms Definitions PDF

Pharmacodynamics - Dose Response relationship- Terms Definitions PDF

Pharmacodynamics. We exactly know what pharmacodynamics is. It involves how the drugs act on target cells to alter cellular function. Let us discuss Dose Response relationship in this article. The exact relationship between the dose and the response depends on the biological object under observation and the drug employed is called Dose Response relationship.

Dose Response relationship

When a logarithm of dose as abscissa and responses as ordinate are constructed graphically, the “S” shaped or sigmoid type curve is obtained.
The lowest concentration of a drug that elicits a response is minimal dose, and the largest concentration after which further increase in concentration will not change the response is the maximal dose.

1. Graded dose effect:

As the dose administered to a single subject or tissue increases, the pharmacological response also increases in graded fashion up to ceiling effect.
– It is used for characterization of the action of drugs. The concentration that is required to produce 50 % of the maximum effect is termed as EC50 or ED50.

2. Quantal dose effect:

It is all or none response, the sensitive objects give response to small doses of a drug while some will be resistant and need very large doses. The quantal dose effect curve is often characterized by stating the median effective dose and the median lethal dose.

Median lethal dose or LD50:

This is the dose (mg/kg), which would be expected to kill one half of a population of the same species and strain.

Median effective dose or ED50:

This is the dose (mg/kg), which produces a desired response in 50 per cent of test population.

Pharmacodynamics - Dose Response relationship- Terms Definitions PDF

Therapeutic index:

It is an approximate assessment of the safety of the drug. It is the ratio of the median lethal dose and the median effective dose. Also called as therapeutic window or safety.
Herapeutic index (T. I) = The larger the therapeutic index, the safer is the drug.

Penicillin has a very high therapeutic index, while it is much smaller for the digitalis preparation.

D. Structural activity relationship 
The activity of a drug is intimately related to its chemical structure. Knowledge about the chemical structure of a drug is useful for:
(i) Synthesis of new compounds with more specific actions and fewer adverse
reactions
(ii) Synthesis of competitive antagonist and
(iii) Understanding the mechanism of drug action.
Slight modification of structure of the compound can change the effect completely.

Download the pdf of this article here to read:

Pharmacodynamics – Dose Response relationship- Terms Definitions PDF

These are few very important terms you need to understand in pharmacodynamics.

 

Hope you like the article. Please share your views comments and doubts in the comments section. We ,love to hear from you and help you.

ROUTES OF DRUG ADMINISTRATION PPT PDF 10 Routes of Drug Administration

Which drug administration route is fastest?,

ROUTES OF DRUG ADMINISTRATION: The possible routes for drug entry into the body. Most drugs can be administered by a variety of routes. The choice of appropriate route in a given situation depends both on drug as well as patient related factors. Mostly common sense considerations, feasibility and convenience dictate the route to be used. Generally routes of drug administration refer to the right path or the required route through which a drug has to be administered into the body to obtain maximum benefit. Here is the list of  5, 10+ outes of drug administration.

  1. oral
  2. sublingual
  3. rectal
  4. nasal
  5. ocular
  6. otic
  7. inhalation
  8. nebulization
  9. transdermal
  10. Subcutaneous (under the skin)
  11. Intramuscular (in a muscle)
  12. Intravenous (in a vein)
  13. Intrathecal (around the spinal cord

Factors governing choice of route

  1. Physical and chemical properties of the drug (solid/ liquid/gas; solubility, stability, pH, irritancy).
  2. Site of desired action—localized and approachable or generalized and not approachable.
  3. Rate and extent of absorption of the drug from different routes.
  4. Effect of digestive juices and first pass metabolism on the drug.
  5. Rapidity with which the response is desired (routine treatment or emergency).
  6. Accuracy of dosage required (i.v. and inhalational can provide fine tuning).
  7. Condition of the patient (unconscious, vomiting).

Routes of Administration can be broadly divided into those for

(a) Local action and (b) Systemic action.

LOCAL ROUTES

These routes can only be used for localized lesions at accessible sites and for drugs whose systemic absorption from these sites is minimal or absent. Thus, high concentrations are attained at the desired site without exposing the rest of the body. Systemic side effects or toxicity are consequently absent or minimal. For drugs (in suitable dosage forms) that are absorbed from these sites/routes, the same can serve as systemic route of administration, e.g. glyceryl trinitrate (GTN) applied on the skin as ointment or transdermal patch. The local routes are:

  1. Topical

This refers to external application of the drug to the surface for localized action. It is often more convenient as well as encouraging to the patient. Drugs can be efficiently delivered to the localized lesions on skin, oropharyngeal/ nasal mucosa, eyes, ear canal, anal canal or vagina in the form of lotion, ointment, cream, powder, rinse, paints, drops, spray, lozengens, suppositories or pesseries. Nonabsorbable drugs given orally for action on g.i. mucosa (sucralfate, vancomycin), inhalation of drugs for action on bronchi (salbutamol, cromolyn sodium) and irrigating solutions/jellys (povidone iodine, lidocaine) applied to urethra are other forms of topical medication.

  1. Deeper tissues

Certain deep areas can be approached by using a syringe and needle, but the drug should be in such a form that systemic absorption is slow, e.g. intra-articular injection (hydrocortisone acetate in knee joint), infiltration around a nerve or intrathecal injection (lidocaine), retrobulbar injection (hydrocortisone acetate behind the eyeball).

  1. Arterial supply

Close intra-arterial injection is used for contrast media in angiography; anticancer drugs can be infused in femoral or brachial artery to localise the effect for limb malignancies.

SYSTEMIC ROUTES

The drug administered through systemic routes is intended to be absorbed into the blood streamand distributed all over, including the site of action, through circulation

  1. Oral

Oral ingestion is the oldest and commonest mode of drug administration. It is safer, more convenient, does not need assistance, noninvasive, often painless, the medicament need not be sterile and so is cheaper. Both solid dosage forms (powders, tablets, capsules, spansules, dragees, moulded tablets, gastrointestinal therapeutic systems— GITs) and liquid dosage forms (elixirs, syrups, emulsions, mixtures) can be given orally.

Limitations of oral route of administration

  • Action of drugs is slower and thus not suitable for emergencies.
  • Unpalatable drugs (chloramphenicol) are difficult to administer; drug may be filled in capsules to circumvent this.
  • May cause nausea and vomiting (emetine).
  • Cannot be used for uncooperative/unconscious/ vomiting patient.
  • Absorption of drugs may be variable and erratic; certain drugs are not absorbed (streptomycin).
  • Others are destroyed by digestive juices (penicillin G, insulin) or in liver (GTN, testosterone, lidocaine).
  1. Sublingual (s.l.) or buccal

The tablet or pellet containing the drug is placed under the tongue or crushed in the mouth and spread over the buccal mucosa. Only lipid soluble and non-irritating drugs can be so administered. Absorption is relatively rapid—action can be produced in minutes. Though it is somewhat inconvenient, one can spit the drug after the desired effect has been obtained. The chief advantage is that liver is bypassed and drugs with high first pass metabolism can be absorbed directly into systemic circulation. Drugs given sublingually are—GTN, buprenorphine, desamino-oxytocin.

  1. Rectal

Certain irritant and unpleasant drugs can be put into rectum as suppositories or retention enema for systemic effect. This route can also be used when the patient is having recurrent vomiting or is unconscious. However, it is rather inconvenient and embarrassing; absorption is slower, irregular and often unpredictable, though diazepam solution and paracetamol suppository are rapidly and dependably absorbed from the rectum in children. Drug absorbed into external haemorrhoidal veins (about 50%) bypasses liver, but not that absorbed into internal haemorrhoidal veins. Rectal inflammation can result from irritant drugs. Diazepam, indomethacin, paracetamol, ergotamine and few other drugs are some times given rectally.

  1. Cutaneous

Highly lipid soluble drugs can be applied over the skin for slow and prolonged absorption. The liver is also bypassed. The drug can be incorporated in an ointment and applied over specified area of skin. Absorption of the drug can be enhanced by rubbing the preparation, by using an oily base and by an occlusive dressing.

 

Transdermal therapeutic systems (TTS)

 

These are devices in the form of adhesive patches of various shapes and sizes (5–20 cm2) which deliver the contained drug at a constant rate into systemic circulation via the stratum corneum (Fig. 1.2). The drug (in solution or bound to a polymer) is held in a reservoir between an occlusive backing film and a rate controlling micropore membrane, the under surface of which is smeared with an adhesive impregnated with priming dose of the drug. The adhesive layer is protected by another film that is to be peeled off just before application. The drug is delivered at the skin surface by diffusion for percutaneous absorption into circulation. The micropore membrane is such that rate of drug delivery to skin surface is less than the slowest rate of absorption from the skin. This offsets any variation in the rate of absorption according to the properties of different sites. As such, the drug is delivered at a constant and predictable rate irrespective of site of application. Usually chest, abdomen, upper arm, lower back, buttock or mastoid region are utilized. Transdermal patches of GTN, fentanyl, nicotine and estradiol are available in India, while those of isosorbide dinitrate, hyoscine, and clonidine are marketed elsewhere. For different drugs, TTS have been designed to last for 1–3 days. Though more expensive, they provide smooth plasma concentrations of the drug without fluctuations; minimize interindividual variations (drug is subjected to little first pass metabolism) and side effects. They are also more convenient— many patients prefer transdermal patches to oral tablets of the same drug; patient compliance is better. Local irritation and erythema occurs in some, but is generally mild; can be minimized by changing the site of application each time by rotation. Discontinuation has been necessary in 2–7% cases.

 

  1. Inhalation

Volatile liquids and gases are given by inhalation for systemic action, e.g. general anaesthetics. Absorption takes place from the vast surface of alveoli—action is very rapid. When administration is discontinued the drug diffuses back and is rapidly eliminated in expired air. Thus, controlled administration is possible with moment to moment adjustment. Irritant vapours (ether) cause inflammation of respiratory tract and increase secretion.

  1. Nasal

The mucous membrane of the nose can readily absorb many drugs; digestive juices and liver are bypassed. However, only certain drugs like GnRH agonists and desmopressin applied as a spray or nebulized solution have been used by this route. This route is being tried for some other peptide drugs like insulin, as well as to bypass the bloodbrain barrier.

  1. Parenteral

Conventionally, parenteral refers to administration by injection which takes the drug directly into the tissue fluid or blood without having to cross the enteral mucosa. The limitations of oral administration are circumvented. Drug action is faster and surer (valuable in emergencies). Gastric irritation and vomiting are not provoked. Parenteral routes can be employed even in unconscious, uncooperative or vomiting patient. There are no chances of interference by food or digestive juices. Liver is bypassed. Disadvantages of parenteral routes are—the preparation has to be sterilized and is costlier, the technique is invasive and painful, assistance of another person is mostly needed (though self injection is possible, e.g. insulin by diabetics), there are chances of local tissue injury and, in general, parenteral route is more risky than oral.

The important parenteral routes are:

(i) Subcutaneous (s.c.)

The drug is deposited in the loose subcutaneous tissue which is richly supplied by nerves (irritant drugs cannot be injected) but is less vascular (absorption is slower than intramuscular). Only small volumes can be injected s.c. Self-injection is possible because deep penetration is not needed. This route should be avoided in shock patients who are vasoconstricted— absorption will be delayed. Repository (depot) preparations that are aqueous suspensions can be injected for prolonged action. Some special forms of this route are:

 (a) Dermojet

In this method needle is not used; a high velocity jet of drug solution is projected from a microfine orifice using a gun like implement. The solution passes through the superficial layers and gets deposited in the subcutaneous tissue. It is essentially painless and suited for mass inoculations.

(b) Pellet implantation

The drug in the form of a solid pellet is introduced with a trochar and cannula. This provides sustained release of the drug over weeks and months, e.g. DOCA, testosterone.

(c) Sialistic (nonbiodegradable) and biodegradable implants

Crystalline drug is packed in tubes or capsules made of suitable materials and implanted under the skin. Slow and uniform leaching of the drug occurs over months providing constant blood levels. The nonbiodegradable implant has to be removed later on but not the biodegradable one. This has been tried for hormones and contraceptives (e.g. NORPLANT).

 (ii) Intramuscular (i.m.)

The drug is injected in one of the large skeletal muscles—deltoid, triceps, gluteus maximus, rectus femoris, etc. Muscle is less richly supplied with sensory nerves (mild irritants can be injected) and is more vascular (absorption of drugs in aqueous solution is faster). It is less painful, but self injection is often impracticable because deep penetration is needed. Depot preparations (oily solutions, aqueous suspensions) can be injected by this route. Intramuscular injections should be avoided in anticoagulant treated patients, because it can produce local haematoma.

(iii) Intravenous (i.v

.) The drug is injected as a bolus (Greek: bolos–lump) or infused slowly over hours in one of the superficial veins. The drug reaches directly into the blood stream and effects are produced immediately (great value in emergency). The intima of veins is insensitive and drug gets diluted with blood, therefore, even highly irritant drugs can be injected i.v., but hazards are—thrombophlebitis of the injected vein and necrosis of adjoining tissues if extravasation occurs. These complications can be minimized by diluting the drug or injecting it into a running i.v. line. Only aqueous solutions (not suspensions, because drug particles can cause embolism) are to be injected i.v. and there are no depot preparations for this route. Chances of causing air embolism is another risk. The dose of the drug required is smallest (bioavailability is 100%) and even large volumes can be infused. One big advantage with this route is—in case response is accurately measurable (e.g. BP) and the drug short acting (e.g. sodium nitroprusside), titration of the dose with the response is possible. However, this is the most risky route—vital organs like heart, brain, etc. get exposed to high concentrations of the drug.

ROUTES OF DRUG ADMINISTRATION 10 Fastest routes

ROUTES OF DRUG ADMINISTRATION 10 Fastest routes PDF

routes of administration PPT

(iv) Intradermal injection

The drug is injected into the skin raising a bleb (e.g. BCG vaccine, sensitivity testing) or scarring/multiple puncture of the epidermis through a drop of the drug is done. This route is employed for specific purposes only.

Search Terms

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Pharmaceutical Chemistry B Pharmacy Second Year Notes || D Pharmacy Material PDF

Pharmaceutical Chemistry B Pharmacy Second Year Notes || D Pharmacy Material PDF

What are Local anaesthetics?
Local anaesthetics – Local anesthetics are drugs which produce insensitivity in a limited area around the site of application or injection of the drug by preventing generation and conduction of impulses along nerve fibers and nerve ending and the effects are reversible.
 What are Anthelmintics 
Anthelmintics – The drugs which are used to kill or remove the parasitic worms, the term anthelmintic should not be restricted just to drugs acting locally to expel worms from the g.i.t. Various types of worms are able to penetrate tissues, & the drugs used to act against systemic infections should be included also under the general term anthelmintic.
 What are anticoagulants?
Anticoagulants – An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting & anticoagulants are given to people to stop thrombosis (blood clotting inappropriately in the blood vessels).
 

What are Diagnostic agents?
Diagnostic agents – These are the agents or chemicals used to detect abnormalities in tissues & organs or to test an organ function, these are thus useful for the clinical diagnosis of the diseases & these agents do not usually have any medicinal values or pharmacological effect.
 

What are sympathomimetics?

Sympathomimetics – Drugs that mimic the actions obtained as a result of stimulation of the sympathetic or adrenergic nerves are called Sympathomimetics.

OR

The drugs that produce pharmacological effects like adrenaline or nor adrenaline or drugs which bring about stimulation of adrenergic nerves are called Sympathomimetics.

Diuretics – Drugs which promote excretion of water & electrolytes from body through kidneys in the form of urine are called diuretics.

Define antimalarials, Classify them with suitable examples and give the structure of

d)

Pyrimethamine.

Anti-malarial drugs: – The drugs which are used in the treatment of malaria caused due

definition

to Plasmodium Species like Plasmodium Vivax, P. falcifrum, P.malariae, P. ovale are called as Anti-malarial drugs.

Classification:

Quinine salts e.g. Quinine sulphate, Quinine phosphate, Quinine dihydrochloride.

8-Aminoquinolines e.g. Pentaquine, Isopentaquine, Pamaquine, Primaquine.

4-Aminoquinolines e.g. Chloroquine , Amodiaquine.

9-Aminoacridines e.g. Quinacrine, Mepacrine.

Biguanides e.g. Proguanil, Cycloguanil

e.g. pyrimethamine.

Artemisinin & its derivatives.

Miscellaneous: – They are further classified as mentioned below

Sulfones & sulfonamides.

Antibiotics

Write physiological actions of histamine. Classify antihistaminics with examples.

Histamine is a biogenic amine involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues.

marks classification

1mark str.

marks physiological actions,

marks classification

Physiological actions of histamine on various organs:

Blood vessels: Histamine causes dilation of blood vessels

Smooth muscle: It causes contraction of smooth muscle (Contraction of bronchi)

Excretory glands: Histamine has stimulant action on excretory glands. It increases nasal, lachrymal and bronchial secretion.

Acid secretion: Histamine increases acid secretion in stomach which causes peptic ulcer

Oedema: Excess secretion of histamine causes accumulation
of fluid and water in the body.

Allergy: It plays an important role in human allergy and allergic reactions.

Classification of antihistaminics:

H1 blockers or H1 antagonist:

Aminoalkylethers/Ethanolamines e.g. Diphenhydramine, Doxylamine

Ethylenediamine e.g.Mepyramine, Tripelennamine, Pyrilamine

Alkylamines/Propylamines e.g. Pheniramine, Chlorpheniramine, Triprolidine d)Phenothiazine derivatives e.g. Promethazine, Trimeprazine

Piperazine derivatives. e.g Meclizine, Cyclizine, Chlorcyclizine

Dibenzocycloheptenes: Cyproheptadine, Azatadine

Second generation antihistaminics: e.g. Cetrizine, Levocetrizine, Fexofenadine, Terfenadine

H2 Blockers or H2 receptor antagonist e.g. Ranitidine, Cimetidine, Famotidine
An inhibitor of histamine release e.g.Sodium Cromoglycate

Define vitamins. Write the important uses of vit. A, Nicotinic acid and ascorbic acid. 1 mark each.
 

Vitamins may be defined as potent organic substances which are essential for normal growth and maintenance of life of human and animals, which are not able to synthesize in adequate quantity.

Uses of Niacin or Nicotinic acid-

It is used for preventing vitamin B3 deficiency and related conditions such as pellagra.
 

Biochemically active form of Nicotinic acid is NAD (Nicotinamide adenine dinucleotide) and its phosphate (NADP). These two coenzymes are required in protein and amino acid metabolism and electron transfer reaction in respiratory chain.
It causes peripheral vasodilation
 

Large dose of nicotinic acid decreases serum cholesterol level.

Uses of Vitamin A-

It is used for treating vitamin A deficiency.

Prevention and treatment of Night blindness, Xerophthalmia and keratomalacia.
 

A is important for growth, development and maintenance of immune system.
 

Some people use vitamin A for improving vision and treating eye disorders including age-related macular degeneration (AMD), glaucoma and

Vitamin A is also used for skin conditions including acne, eczema, psoriasis, cold sores, wounds, burns, sunburn.

Uses of Ascorbic acid-

In general this drug is used for the prevention and treatment of scurvy. This condition is caused by a lack of vitamin C often due to a lack of fresh fruit and vegetables. Symptoms of scurvy include a general feeling of being unwell, tiredness, muscle and joint pain, bleeding into the skin, around bones, into joints and from the gums, and loose teeth.
Ascorbic acid is involved in many redox reactions

(ii) Pethidine

Uses of Pethidine-

Analgesic activity: It is used in the treatment of severe pain like labor pain.
 

Spasmolytic agent: Pethidine is useful in the treatment of spasm of intestine, urinary bladder
 

Used as a substitute for morphine for the relief of most types of moderate to severe pains.
 

Used in combination with chlorpromazine & promethazine to produce narcosis.
 

It also produces mild euphoria.

h)

Give storage conditions for

Heparin
 

The aqueous solution is stable for at least 7 years at pH 7 to 8.

It is stored in sealed, sterile container so as to exclude microorganism and moisture.

Cyclopropane
 

It is stored in metal cylinder designed to hold compressed gases and kept in a cool room free from inflammable material.

The whole cylinder is painted orange. The shoulder should be stenciled with name or symbol “C3H6”. The name or symbol should be clearly stamped on the cylinder valve.

d) Write the difference between general anaesthetics and local anaesthetics. Give the

structure and chemical name of procaine.

2 marks for

Structure of procaine

differences

O

H2N                                                  C          O                                           C2H5

N

C2H5

Chemical name – 4-amino-(2-diethyl amino ethyl) benzoate or 2-(Diethyl amino)

ethyl-4-amino benzoate.

Distinguish between general anaesthetics and local anaesthetics

GENERAL ANAESTHETICS LOCAL ANAESTHETICS

1. General anaesthetics are the agents which It may be defined as any substance
bring about loss of all modalities of sensation, applied topically or by localized
particularly pain, along with a reversible loss
injection or infiltration to dull or block
of consciousness.

. pain sensation.

2. General anesthesia is induced either by Local anesthesia is induced by topical
inhalation of volatile & gaseous anesthetics application of drugs to skin or mucous
like diethyl ether, halothane or parenteral membrane (surface anesthesia) or by
administration of intravenous anesthetics injection into area subjected to surgical
like thiopentone sodium. operation (infiltration anaesthesia) or

injection into dual membrane of spinal

cord (spinal anesthesia)

3. General anaesthesia is produced before Local Anaesthesia is produced in short
carrying out surgical operation or in surgical procedures & in dentistry.
obstetrics.

4.Care of Vital organs essential Care of Vital organs is not essential

 E.g. halothane ,cycloprapane etc. E.g. procaine, lignocaine, benzocaine

Define and classify antihypertensive drugs.

Any agent used for reducing elevated blood pressure is known as antihypertensive agent or hypotensive agent.

Antihypertensive agents can be classified as follows below:-

Centrally acting agents: e.g. α-methyldopa, clonidine

Ganglion blockers : e.g. Pentolinium, Mecamylamine

Adrenergic neuron blockers e.g. Reserpine, Guanethidine

β-adrenergic blockers e.g. Propranalol, Atenolol

α-adrenergic blockers e.g. Prazosin, Tolazoline

Direct-acting vasodilators e.g. Hydralazine, Minoxidil

Calcium channel blockers eg. Verapamil

Angiotensin converting enzyme inhibitors (ACE inhibitors) e.g.Captopril, enalapril maleate.

mark definition

marks classification

3. Attempt any THREE of the following:

Write the general uses of diuretics. Give the structure and brand names of frusemide.
 

General uses of Diuretics:-

Diuretics are used to treat several conditions in medicine. Following are the conditions where diuretics are used

Hypertension or high blood pressure, Acute left ventricular failure or heart failure

Most types of oedema (renal oedema, oedema of pregnancy) or fluid accumulation

Acute renal failure and treatment of kidney stones

To excrete toxins and toxic metabolites out of the body.

To decreases intraocular pressure in glaucoma.

Treatment of hypercalcemia and hyperkalemia

Frusemide: Lasix, Fru, Frusenex, Tebemid etc.

Structure of frusemide:-

Define and classify NSAIDs.

b)

NSAIDs is an abbreviation for a group of agents called Non Steroidal Anti-inflammatory Drugs.

De

A. Nonselective COX inhibitors (conventional NSAIDs)

Salicylates: Aspirin, Diflunisal

Para Amino Phenol Derivatives- Phenacetin, Paracetamol (Acetaminophen)

Pyrazolone derivatives: Phenylbutazone, Oxyphenbutazone

Indole derivatives: Indomethacin, Sulindac

Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen

Anthranilic acid derivatives: Mephenamic acid
Aryl‐acetic acid derivatives: Diclofenac.

Oxicam derivatives: Piroxicam
Pyrrolo‐pyrrole derivative: Ketorolac
Preferential COX‐2 inhibitors: Nimesulide, Meloxicam, Nabumetone

Selective COX‐2 inhibitors: Celecoxib, Rofecoxib, Valdecoxib

Write any one important use of Indigo carmine, Evans blue, Fluorescein Sodium and Congo red.
 

Uses of Indigo carmine

It is administered intravenously to test renal function (by estimating the rate of excretion in urine) & to locate the uretheral orifices.
 

In the lab it is used as coloring agents.

Uses of Evans blue

Evans Blue is a di-azo compound used to determine blood volume in humans and animals.
 

The dye combines firmly with plasma albumin when injected into the blood stream and leaves the circulation very slowly.

Marks classification

1 Mark each

Page 17 of 32

MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION

(Autonoalium, Placidox, Anaxol, Quietal, Diazewok, Zepose, Microdep

.

What    is    epilepsy?     Classify    anticonvulsants     and    write    the    structure     of

 

Epilepsy is a disease which arises due to the disorders of control nervous system. This disease is characterized by somewhat more or less frequent recurrence of seizures in

which there occur convulsions or other abnormal body movements, which are accompanied by loss or disturbance in consciousness. Anticonvulsants are classified as:

Barbiturates: – Barbitone sodium, Phenobarbitone, Methyl phenobarbitone.

Hydantoins :- Phenytoin, Mephenytoin

Oxazolidinediones :-Trimethadione, Paramethadione

Succinimides :- Ethosuximide, Phensuximide

Benzodiazepines: Diazepam, Clonazepam, Lorazepam, Nitrazepam

Miscellaneous :- Primidone, Carbamazepine, Valproic acid, Phenacemide, Pregabalin, Gabapentin

Phenobarbitone Structure

Define and classify narcotic analgesic drugs.
 

Narcotic analgesics are derivatives of opium, semi synthetic or synthetic agents having potent analgesic & narcotic activity and effective for the treatment of severe pain. Classification of Narcotic analgesics

Narcotic analgesic are classified as:-

Morphine and related compounds (Natural alkaloids of opium) e.g. Morphine, Codeine.

Semi-synthetic derivatives of morphine- Heroin, Brown Sugar
Marks Classification 1Mark str.

Mark definition

Marks classify.

Synthetic Agents- Methadone, Pethidine, Dextropropoxyphen hydrochloride

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What do you know about sex hormones? Give the uses of Progesterone and Cortisone.
 

Sex hormones are the hormones which are produced mainly in gonads, ovaries or testes. They influence the development and maintenance of the structures directly and indirectly associated with reproduction. Three main types of sex hormones are

Androgenic or anabolic steroids :-

The androgens are mainly able to maintain the development and maintenance of the secondary male sex characters, thereby increasing virility and libido.

Oestrogens :- Oestrogens influence development and maintenance of secondary female sex characters. They are also essential for maintenance of pregnancy. They also exert anabolic effect on protein metabolism & water retention.

Progestogens.:-

Progestogens are necessary for various changes takes place in uterus & vagina during menstrual cycle, for developing mammary tissue and for maintain pregnancy.

Uses of Progesterone:

It is used as a hormonal replacement therapy in deficiency of progesterone.
 

It is used in treatment of dysfunctional uterine bleeding.
 

It is also used along with estrogen in menstrual disorders, premenstrual tension
 

It is used in treatment of neoplasm of breast and endometriosis.
 

It has also been incorporated into an intra-uterine device for female contraception.
 

Treatment of habitual abortion.
 

Maintenance of pregnancy if it occurs.

Uses of Cortisone:

Anti-inflammatory action: Cortisone is a steroid that prevents the release of substances in the body that cause inflammation.
 

Cortisone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, or breathing disorders.

1 Mark sex hormones,

1.5 Marks to uses of each drug

Subject Title: Pharmaceutical Chemistry-I I Subject Code:

Treatment of rheumatoid arthritis and osteoarthritis
 

Treatment of lung infection
 

Treatment of allergic conjunctivitis
 

It has immune suppressant action hence used in organ transplantation and autoimmune disorder.
 

Treatment of Addison’s disease.
 

Write the structure and uses of
 

Atropine

Atropine Uses:

Atropine has antispasmodic action on smooth muscles, hence used for the treatment of gastric and duodenal ulcers and for the relief of renal and biliary colics.
Useful in symptomatic treatment of Parkinsonism.
 

It is one of the components of pre-anaesthetic medication, where it is given to reduce salivary and bronchial secretions and to diminish the risk of vagal inhibition of the heart.
 

It is used by ophthalmologist for its mydriatic effects.
 

Treatment of hyperhidrosis (Abnormal increased sweating)

1Mark Str.

1Mark use.

Propranolol

Propranolol Uses:

Treatment of various cardiac diseases like Cardiac arrhythmia, Arterial hypertension,
 

Angina pectoris, congestive heart failure, coronary atherosclerosis, tacycardia
 

Treatment of Pheochromocytoma (cancer of adrenal glands)
 

Treatment of glaucoma

5. Attempt any THREE of the following.

Write structure, chemical name uses and brand names of Paracetamol

a)

Structure

Chemical name: p-hydroxy acetanilide OR 4-hydroxy acetanilide OR 4-Acetylaminophenol

Uses:

Antipyretic
 

Analgesics for relief of pain such as headache, toothache, neuralgia, rheumatism.

Brand names- Tylenol, Calpol, panadol, crocin, metacin, valadol, paldesic, Dolo

Define antiseptics and disinfectants. Classify them with examples

b)

Def:  Antiseptic and disinfectants are the chemical agents which are employed to destroy

Pharmaceutical Chemistry

or inhibit the growth of pathogenic microorganism. Antiseptics are applied on living tissues while disinfectants are used on inanimates or non living objects.

CLASSIFICATION

1) Alcohols & Aldehydes

E.g. Ethyl Alcohol, Isopropyl alcohol,  Formaldehyde

2) Halogen Compounds.

E.g. Chloramine T, Chorhexidine Acetate, Dibromopropamidine Isothionate.

3) Phenols & Related Compounds

E .g. Phenol, Chlorocresol, Chloroxylenol, Cresol, Hexachlorophene, Thymol.

4) Mercury Compounds.

E.g. , Thiomersal, Mercuric chloride

5) Dyes.

E.g. Proflavine Hemisulphate, Acriflavine, Brilliant Green, Crystal Violet (Gentian Violet), Methylene Blue.

6) Surface Active Agents

E.g. Benzalkonium Chloride, Cetrimide, Cetylpyridinium Chloride, Domiphen Bromide,

7) Miscellaneous Agents.

E.g.   Dequalinum Sulphate, Nitrofurazone.

Give structure, chemical name and uses of D.E.C.

Structure

M classification

2 M structure

1 M chemical name

1M uses

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Chemical name: 7-Chloro-4-[4’-(diethylamino)-1-methyl butyl] amino quinoline

Dosage forms:

Chlroquine Phosphate Injection

Chlroquine Phosphate Tablets

Chlroquine Syrup

Chroquine Sulphate Injection

Chroquine Sulphate tablet

Brand Names: Cadiquin, Cloquin, Emquin, Lariago, Aralen, Avioclor, Quinross, Resochin, Nivaquine

Attempt any THREE of the following:
 

What are anti-amoebic agents? Classify them with suitable examples.

Anti-amoebic agents: The drugs which are used in the treatment of amoebic infection caused by Entamoeba histolytica are called as antiamoebic drugs.
 

Classification of antiamoebic drugs:

Drugs of natural origin: g. emetin
 

Synthetic drugs:
 

Quinoline derivative e.g. Chloroquine

Halogenated-8-hydroxyquinoline derivative e.g. quinidochlor, Diiodohydroxyquinoline

Nitro-imidazole derivative e.g. Metronidazole, Tinidazole

rks

M definition

M classification

Page 27 of 32

Antibiotic: e.g. Paramomycin, Tetracycline, chlortetracycline, oxythromycin

Organic arsenicals: e.g. carbarsone

Miscellaneous e.g Diloxanide furoate

Explain the process of blood coagulation. Write the structure and chemical name of

 
Process of blood coagulation:

Thrombin and several clotting factors present in plasma and calcium ions are involved in the coagulation. Process of blood coagulation can be described as follows.
 

Whenever there is an injury to a blood vessel, there is formation of rough surface. When blood platelets come in contact with such a rough surface, they are injured.
 

Due to injury, they release the substance called thromboplastin. In the presence of thromboplastin and calcium in the blood plasma prothrombin is converted into thrombin which helps in conversion of fibrinogen to fibrin.
 

The fibrin is insoluble and forms threads. The threads of fibrin form a net. In the holes of this net, blood cells are entangled. This mass then contracts to form a blood clot.

i) Indomethacine

Pharmaceutical Chemistry B Pharmacy Second Year Notes || D Pharmacy Material PDF
Uses:

Anti-inflammatory and analgesic in rheumatoid arthritis

Treatment of spondylitis, osteoarthritis and in gout

Treatment of dysmenorrhea and migraine.

Uses:

To relieve bronchial spasm in acute attacks of asthma.

It is used to increase blood pressure in treatment of hypotension.

Intra venous administration of Adrenaline is used to treat acute circulary collapse or cardiac arrest.

Treatment of allergic disorder.

Treatment of superficial bleeding due to its vasoconstriction effect.

Added to local anesthetic to prolong the duration of effect.

It has mydriatic effect.
 

Define and classify cholinergic drugs. Write the uses of Acetylcholine Definition:
 

The agents that mimic the action of acetylcholine or produce the effect of parasympathetic nerve stimulation are called as cholinergic drugs or parasympathomimetic agents.

Classification:

Choline esters: Acetylcholine, Methacholine, Carbachol

Cholinomimetic alkaloids: Muscarine, Pilocarpine, Arecholine

Cholinesterase inhibitors (Indirectly acting)

Reversible Inhibitors- Physostigmine, Neostigmine, Pyridostigmine

Irreversible Inhibitors- Organophosphates (Parathion, Malathion), Insecticides.

Uses of Acetylcholine:

It reduces intraocular pressure in glaucoma

In the relief of atony of gut and urinary bladder