Fermentation Systems: @ Bioprocessing & Biopharmaceutical

Fermentation Systems: Powering Bioprocessing and Biopharmaceutical Production
Fermentation systems are a crucial category of bioprocessing equipment that plays a fundamental role in the production of various biopharmaceuticals, enzymes, biofuels, and other bioproducts. These systems provide a controlled environment for the cultivation and growth of microorganisms, such as bacteria, yeast, or fungi, which are used to produce valuable products through fermentation processes. In this comprehensive guide, we will explore fermentation systems in detail, covering their types, components, working principles, applications, and the critical role they play in advancing bioprocessing and biopharmaceutical production.

Table of Contents

Introduction to Fermentation Systems

Understanding Fermentation
The Importance of Fermentation Systems
Role of Fermentation in Bioprocessing

Types of Fermentation Systems

Batch Fermentation
Continuous Fermentation
Fed-Batch Fermentation

Components of Fermentation Systems

Fermenters and Bioreactors
Sensors and Controls
Agitation and Aeration Systems
Sterilization and CIP Systems

Working Principles of Fermentation Systems

Microbial Growth and Metabolism
Oxygen Transfer and Mixing
Temperature Control
pH and Nutrient Regulation

Applications of Fermentation Systems

Pharmaceutical and Biopharmaceutical Production
Enzyme and Biochemical Manufacturing
Biofuel Production
Food and Beverage Industry

Challenges and Advances in Fermentation Systems

Scaling Up and Down
Contamination Control
Automation and Process Monitoring
Advances in Microbial Engineering

Future Trends in Fermentation Systems

Synthetic Biology and Strain Optimization
Sustainability and Bioprocess Intensification
Integration with Industry 4.0 Technologies
Personalized Medicine and Precision Fermentation

1. Introduction to Fermentation Systems

Understanding Fermentation

Fermentation is a biological process wherein microorganisms, such as bacteria, yeast, or fungi, convert organic substances into valuable products by anaerobic or aerobic metabolism. This natural process has been harnessed by humans for centuries to produce a wide range of products, including alcoholic beverages, bread, and dairy products. In the context of bioprocessing and biopharmaceutical production, fermentation is a controlled and highly regulated process used to generate pharmaceuticals, enzymes, biofuels, and various biochemicals.

The Importance of Fermentation Systems

Fermentation systems, often referred to as fermenters or bioreactors, are designed to provide the optimal conditions required for the growth and metabolic activity of microorganisms. These systems are pivotal in ensuring the success of fermentation processes in a controlled and reproducible manner. The biopharmaceutical industry, in particular, heavily relies on fermentation systems for the production of biologics such as monoclonal antibodies, vaccines, and other therapeutic proteins.

Role of Fermentation in Bioprocessing

Fermentation serves as a critical step in bioprocessing, bridging the gap between laboratory-scale research and large-scale production. Fermentation systems enable the cultivation of microorganisms at various scales, from small laboratory fermenters to industrial-scale bioreactors. They offer precise control over environmental factors such as temperature, pH, dissolved oxygen levels, and nutrient supply, ensuring the optimal growth and productivity of microbial cultures.

2. Types of Fermentation Systems

Fermentation systems can be categorized into different types based on their operational mode:

Batch Fermentation

Operation: In batch fermentation, microorganisms are cultivated in a closed system with a fixed volume of nutrient medium. The entire process, from inoculation to product harvesting, occurs in a single batch.
Applications: Batch fermentation is commonly used in research and development, small-scale production, and when product variability is not a concern.

Continuous Fermentation

Operation: In continuous fermentation, fresh nutrient medium is continuously added to the system, while an equal volume of spent medium is removed at the same rate. This allows for a continuous flow of microorganisms and nutrients.
Applications: Continuous fermentation is suitable for large-scale production of consistent products, such as biofuels and certain chemicals.

Fed-Batch Fermentation

Operation: Fed-batch fermentation combines aspects of both batch and continuous processes. Nutrients are intermittently added to the system to maintain favorable growth conditions without diluting the culture.
Applications: Fed-batch fermentation is widely used in biopharmaceutical production to maximize product yield and control the growth rate of microorganisms.
The choice of fermentation type depends on factors such as the product being manufactured, scale of production, and process economics.

3. Components of Fermentation Systems

Fermentation systems are composed of several critical components that work in concert to facilitate microbial growth and product formation:

Fermenters and Bioreactors

Description: Fermenters and bioreactors are vessels designed to house microbial cultures. They come in various sizes and configurations, including benchtop fermenters for research and industrial-scale bioreactors for large-scale production.
Function: These vessels provide a controlled environment where temperature, pH, agitation, and aeration are regulated to support optimal microbial growth and product formation.

Sensors and Controls

Description: Sensors, such as pH probes, dissolved oxygen sensors, and temperature probes, monitor key process parameters in real time. Control systems adjust conditions based on sensor feedback.
Function: Sensors and controls maintain precise environmental conditions, ensuring that the microorganisms thrive and produce the desired product consistently.

Agitation and Aeration Systems

Description: Agitation systems, which typically include impellers or stirrers, ensure the even distribution of nutrients and oxygen throughout the culture. Aeration systems supply oxygen to support aerobic metabolism.
Function: Effective mixing and aeration promote microbial growth and prevent the formation of oxygen-deprived zones within the culture.

Sterilization and CIP Systems

Description: Sterilization systems, such as autoclaves, ensure that all components of the fermentation system are free from contaminants before the start of a new batch. Clean-in-place (CIP) systems clean and sanitize the equipment between batches.
Function: Sterilization and CIP systems are essential for preventing contamination and maintaining product purity.

4. Working Principles of Fermentation Systems

The operation of fermentation systems relies on several fundamental principles:

Microbial Growth and Metabolism

Description: Microorganisms, such as bacteria or yeast, require a nutrient-rich medium that provides essential nutrients like carbon, nitrogen, and minerals. The microorganisms metabolize these nutrients to generate energy and produce the desired product.
Function: Fermentation systems create an environment where microbial growth and metabolism can occur optimally.

Oxygen Transfer and Mixing

Description: Adequate oxygen supply is critical for aerobic fermentation, as it supports the production of energy and certain products. Mixing systems ensure that oxygen is distributed evenly throughout the culture.
Function: Oxygen transfer and mixing systems maintain the appropriate oxygen levels for microbial growth.

Temperature Control

Description: Temperature control is vital because microorganisms have specific temperature requirements for growth. Fermentation systems use heating and cooling mechanisms to maintain the desired temperature.
Function: Temperature control ensures that the culture remains within the optimal temperature range for microbial activity.

pH and Nutrient Regulation

Description: pH levels and nutrient concentrations must be carefully regulated to create a favorable environment for microbial growth. pH can impact enzyme activity, and nutrient levels affect growth rates.
Function: pH and nutrient regulation systems maintain the conditions necessary for microbial growth and product formation.

5. Applications of Fermentation Systems

Fermentation systems find diverse applications across various industries, including:

Pharmaceutical and Biopharmaceutical Production

Description: Fermentation systems are extensively used in the production of biopharmaceuticals such as monoclonal antibodies, therapeutic proteins, and vaccines.
Function: They provide a controlled environment for the cultivation of mammalian cells or microorganisms that produce biologics.

Enzyme and Biochemical Manufacturing

Description: Fermentation is employed to produce enzymes and biochemicals used in various applications, including food processing, detergents, and biofuels.
Function: These systems enable the efficient and cost-effective production of enzymes and biochemical products.

Biofuel Production

Description: Fermentation systems are utilized to convert biomass into biofuels such as ethanol, biodiesel, and biogas.
Function: They support the fermentation of sugars and organic materials to produce biofuels with potential environmental benefits.

Food and Beverage Industry

Description: Fermentation is integral to the production of a wide range of food and beverage products, including yogurt, cheese, bread, and alcoholic beverages.
Function: Fermentation processes enhance flavor, texture, and preservation in these products.

6. Challenges and Advances in Fermentation Systems

Fermentation systems have evolved significantly over the years, addressing challenges and incorporating advances to improve their efficiency and productivity:

Scaling Up and Down

Challenge: Transitioning from laboratory-scale fermentation to large-scale production can be complex due to differences in equipment, process optimization, and scale-up challenges.
Advances: Improved scaling methodologies, as well as the development of standardized components and systems, have made scaling up and down more manageable.

Contamination Control

Challenge: Maintaining sterility and preventing contamination is critical in fermentation. Contamination can result in batch failure and product loss.
Advances: Advances in sterilization technology, stringent aseptic techniques, and the use of single-use bioreactors have enhanced contamination control.

Automation and Process Monitoring

Challenge: Maintaining consistent and precise control of fermentation parameters can be challenging, especially in large-scale bioreactors.
Advances: Automation systems equipped with sensors and control algorithms enable real-time monitoring and adjustment of critical parameters, improving process robustness and reproducibility.

Advances in Microbial Engineering

Challenge: Strain development and optimization are essential for increasing product yields and improving the efficiency of microbial fermentation.
Advances: Advances in synthetic biology, genetic engineering, and strain development techniques have led to the creation of high-performing microorganisms.

7. Future Trends in Fermentation Systems

The future of fermentation systems is marked by several promising trends and innovations:

Synthetic Biology and Strain Optimization

Trend: Continued advancements in synthetic biology will enable the engineering of microorganisms with enhanced capabilities for producing valuable products.

Sustainability and Bioprocess Intensification

Trend: Bioprocessing is increasingly focused on sustainability, with efforts to reduce resource consumption and waste generation. Process intensification aims to enhance product yield and reduce production costs.

Integration with Industry 4.0 Technologies

Trend: The integration of Industry 4.0 technologies, including IoT sensors, data analytics, and machine learning, will enable smarter and more efficient fermentation processes.
Personalized Medicine and Precision Fermentation
Trend: In the field of biopharmaceuticals, personalized medicine and precision fermentation are emerging trends, where therapies are tailored to individual patients using advanced fermentation techniques.

8. Conclusion

Fermentation systems are at the forefront of bioprocessing and biopharmaceutical production, enabling the efficient and controlled cultivation of microorganisms for various applications. Their versatility, scalability, and ability to provide precise control over critical parameters make them indispensable tools in industries ranging from pharmaceuticals to food production. As advances in biotechnology continue to shape the future, fermentation systems will remain pivotal in harnessing the power of microorganisms to produce valuable products, drive sustainability, and improve healthcare.

Bioprocessing Equipment: Biopharmaceutical Production

Bioprocessing Equipment: Enabling Advanced Biopharmaceutical Production

Bioprocessing equipment plays a pivotal role in the field of biopharmaceutical manufacturing, enabling the production of complex therapeutic drugs, vaccines, and biologics. These sophisticated systems are essential for cultivating, harvesting, purifying, and formulating biopharmaceuticals derived from living cells or organisms. In this comprehensive guide, we will explore the world of bioprocessing equipment, covering its types, functions, applications, and the critical role it plays in advancing healthcare and the biotechnology industry.

Table of Contents

Introduction to Bioprocessing Equipment

  • Understanding Bioprocessing
  • The Importance of Biopharmaceuticals
  • Role of Bioprocessing Equipment

Types of Bioprocessing Equipment

  • Fermentation Systems
  • Bioreactors
  • Downstream Processing Equipment
  • Filtration and Separation Systems
  • Cell Culture Equipment

Functions of Bioprocessing Equipment

  • Cell Growth and Cultivation
  • Monitoring and Control
  • Harvesting and Separation
  • Purification and Formulation

Applications of Bioprocessing Equipment

  • Pharmaceutical Industry
  • Biotechnology
  • Vaccine Production
  • Research and Development

Key Considerations in Bioprocessing Equipment Selection

  • Scalability
  • Sterility and Contamination Control
  • Automation and Monitoring
  • Regulatory Compliance

Advancements in Bioprocessing Equipment

  • Single-Use Bioprocessing
  • Continuous Bioprocessing
  • Integration of Industry 4.0 Technologies
  • Emerging Trends

Challenges and Future Directions

  • Cost-Efficiency and Sustainability
  • Process Intensification
  • Personalized Medicine
  • Regulatory Landscape


1. Introduction to Bioprocessing Equipment

Understanding Bioprocessing

Bioprocessing is a branch of biotechnology that involves the use of living cells, enzymes, and biological molecules to manufacture valuable products. It encompasses a wide range of processes, including the production of biopharmaceuticals, biofuels, enzymes, and other bioproducts. In the context of this guide, we focus on bioprocessing as it relates to the production of biopharmaceuticals.

The Importance of Biopharmaceuticals

Biopharmaceuticals, often referred to as biologics, are a class of therapeutic drugs derived from living organisms or their components. These drugs have revolutionized the treatment of various diseases, including cancer, autoimmune disorders, and infectious diseases. Unlike traditional small-molecule drugs, biopharmaceuticals are highly specific, offering targeted therapies with fewer side effects.

Role of Bioprocessing Equipment

Bioprocessing equipment serves as the backbone of biopharmaceutical manufacturing. It provides the necessary tools and technologies for the cultivation, maintenance, and processing of living cells or organisms that produce biopharmaceuticals. This equipment ensures the controlled and efficient production of biologics while adhering to strict quality and safety standards.

2. Types of Bioprocessing Equipment

Bioprocessing equipment encompasses a diverse range of machinery and systems tailored to different stages of biopharmaceutical production. Below are the primary types of bioprocessing equipment:

Fermentation Systems

Fermentation systems are used for the cultivation and growth of microorganisms, such as bacteria, yeast, or fungi, to produce biopharmaceuticals. Key components include fermenters and bioreactors, which provide a controlled environment for microbial growth and product formation.

Read more on Fermentation systems


Bioreactors are specialized vessels designed to support the growth of mammalian cells or microbial cultures. They provide optimal conditions for cell growth, including temperature, pH, oxygen supply, and agitation. Bioreactors come in various configurations, such as stirred-tank, wave, and disposable bioreactors.

Downstream Processing Equipment

Downstream processing equipment is responsible for separating and purifying biopharmaceutical products from the cell culture broth. This stage involves a series of steps, including cell disruption, clarification, chromatography, and filtration. Common equipment includes centrifuges, chromatography columns, and filtration systems.

Filtration and Separation Systems

Filtration and separation systems are essential for removing impurities and particles from biopharmaceutical products. These systems employ various techniques, including ultrafiltration, microfiltration, and depth filtration, to achieve the desired product purity.

Cell Culture Equipment

Cell culture equipment includes incubators, shakers, and bioreactors designed for the cultivation of mammalian cells. These systems provide a controlled environment with precise conditions for cell growth and product expression.

3. Functions of Bioprocessing Equipment

Bioprocessing equipment performs a range of critical functions throughout the production of biopharmaceuticals:

Cell Growth and Cultivation

Optimal Environment: Maintains ideal conditions for cell growth, including temperature, pH, dissolved oxygen levels, and nutrient supply.
Scaling Up: Enables the transition from laboratory-scale cultures to larger production volumes while maintaining consistent growth conditions.

Monitoring and Control

Real-time Monitoring: Provides continuous data on key parameters, allowing for immediate adjustments to maintain product quality.
Automation: Offers automated control of variables like temperature and agitation to ensure reproducibility.

Harvesting and Separation

Cell Harvesting: Gently harvests cells or microorganisms from the culture broth without damaging them.
Clarification: Removes solid particles and debris from the culture broth.

Purification and Formulation

Protein Purification: Utilizes chromatography and filtration techniques to isolate and purify the target biopharmaceutical.
Formulation: Prepares the final product by combining purified biopharmaceuticals with stabilizers, buffers, and other necessary components.

4. Applications of Bioprocessing Equipment

Bioprocessing equipment finds applications in various industries, with a primary focus on the production of biopharmaceuticals. Key sectors include:

Pharmaceutical Industry

Monoclonal Antibodies: Production of monoclonal antibodies for cancer and autoimmune disease treatments.
Vaccines: Manufacture of vaccines against infectious diseases.
Gene Therapies: Production of gene-based therapies to treat genetic disorders.


Enzyme Production: Industrial-scale production of enzymes used in various applications, including food processing and biofuel production.
Biofuels: Production of biofuels such as ethanol and biodiesel.

Vaccine Production

Influenza Vaccines: Large-scale production of influenza vaccines during flu seasons.
COVID-19 Vaccines: Rapid production of vaccines to combat the COVID-19 pandemic.

For Detailed Applications of Bioprocessing Equipment Click here

Research and Development

Biological Research: Support for research laboratories working on novel biopharmaceuticals and biotechnological advancements.
Bioprocess Development: Equipment is used to optimize and scale up bioprocesses for potential commercialization.

5. Key Considerations in Bioprocessing Equipment Selection

Selecting the right bioprocessing equipment is crucial for efficient and compliant biopharmaceutical production. Several key considerations guide this selection process:


Equipment should be scalable to accommodate the transition from laboratory-scale research to large-scale manufacturing.

Sterility and Contamination Control

Strict adherence to aseptic techniques and equipment design to prevent contamination and maintain product integrity.

Automation and Monitoring

Automation capabilities for precise control and monitoring of critical parameters to ensure product consistency.

Regulatory Compliance

Compliance with regulatory guidelines, such as Good Manufacturing Practices (GMP) and validation requirements, to meet quality and safety standards.

6. Advancements in Bioprocessing Equipment

Bioprocessing equipment continues to evolve to meet the increasing demand for biopharmaceuticals and to improve process efficiency. Several advancements have shaped the field:

Single-Use Bioprocessing

The adoption of single-use bioreactors and disposable components, reducing the risk of contamination and simplifying equipment setup and teardown.

Continuous Bioprocessing

Transitioning from batch processes to continuous processes, enabling higher productivity and reduced production timelines.

Integration of Industry 4.0 Technologies

Incorporating technologies like data analytics, artificial intelligence, and Internet of Things (IoT) for real-time monitoring and optimization.

Emerging Trends

Exploration of novel bioprocessing techniques, such as cell-free systems and 3D bioprinting, to expand biopharmaceutical production capabilities.

7. Challenges and Future Directions

While bioprocessing equipment has made significant strides, several challenges and future directions deserve attention:

Cost-Efficiency and Sustainability
Addressing the cost of biopharmaceutical production and minimizing resource consumption while maintaining product quality.
Process Intensification
Enhancing process efficiency and productivity through intensified bioprocessing strategies.
Personalized Medicine
Adapting bioprocessing techniques to support the emerging field of personalized medicine, where therapies are tailored to individual patients.
Regulatory Landscape
Navigating evolving regulatory requirements and ensuring compliance in a rapidly changing industry.

8. Conclusion

Bioprocessing equipment is at the heart of biopharmaceutical manufacturing, enabling the production of life-saving drugs and therapies. With continuous advancements and a growing demand for biologics, the field of bioprocessing equipment is poised for further innovation. As researchers and industry professionals continue to push the boundaries of biotechnology, the role of bioprocessing equipment in improving healthcare and addressing global health challenges remains indispensable.

Applications of Bioprocessing Equipment in Pharmaceutical Industry

Bioprocessing equipment plays a pivotal role in the pharmaceutical industry, enabling the production of complex and highly effective biopharmaceutical products. These products, which include monoclonal antibodies, vaccines, gene therapies, and other bio-based drugs, have revolutionized the treatment of various diseases. In this section, we will delve into the applications of bioprocessing equipment in the pharmaceutical industry in detail.

Monoclonal Antibody Production:

Bioprocessing equipment is extensively used in the production of monoclonal antibodies (mAbs), which are a class of biopharmaceuticals designed to target specific proteins or cells in the body. These antibodies have been instrumental in treating various diseases, including cancer and autoimmune disorders. Bioreactors, in particular, play a critical role in the cultivation of mammalian cells that produce mAbs. These reactors provide optimal conditions for cell growth, including temperature, pH, oxygen supply, and agitation. Continuous monitoring and control systems ensure that the production process remains consistent and yields high-quality mAbs.

Vaccine Manufacturing:

The pharmaceutical industry relies heavily on bioprocessing equipment for vaccine production. This has been particularly evident in the rapid development and production of vaccines against infectious diseases like COVID-19. Bioreactors and fermentation systems are employed to grow and propagate the virus or antigen used in the vaccine. Downstream processing equipment is then used to harvest and purify the viral particles or antigens, ensuring the final vaccine is safe and effective. The scalability of bioprocessing equipment is crucial in vaccine production, as large quantities are often required to meet global demand.

Gene Therapy:

Gene therapy, a rapidly advancing field in the pharmaceutical industry, involves the introduction, deletion, or correction of genetic material within a patient’s cells to treat or cure genetic disorders. Bioprocessing equipment is integral to the production of viral vectors used in gene therapy. These vectors, often derived from viruses like adenoviruses or lentiviruses, require large-scale cultivation and purification. Bioreactors, filtration systems, and chromatography columns are essential for the production of viral vectors with high purity and potency.

Cell-Based Therapies:

Emerging cell-based therapies, such as CAR-T cell therapy and stem cell therapies, have shown remarkable potential in treating cancer and regenerative medicine. Bioprocessing equipment is indispensable in these therapies for the expansion and manipulation of patient-derived cells. Bioreactors and cell culture equipment provide the controlled environment needed for cell growth and gene editing. Moreover, downstream processing equipment ensures that the final cell-based products are free from contaminants and meet stringent quality standards.

Biopharmaceutical Research and Development:

Beyond large-scale production, bioprocessing equipment plays a critical role in pharmaceutical research and development (R&D). Laboratories use benchtop bioreactors, cell culture equipment, and other bioprocessing tools to develop and optimize biopharmaceutical processes at smaller scales. This allows researchers to explore new drug candidates, test hypotheses, and conduct feasibility studies before moving to commercial production.

Bioprocessing equipment in the pharmaceutical industry is not limited to production alone; it also extends to quality control, ensuring that biopharmaceutical products meet the highest standards of safety, efficacy, and purity. High-performance liquid chromatography (HPLC), mass spectrometers, and other analytical instruments are used to analyze and characterize biopharmaceuticals.

In conclusion, bioprocessing equipment is indispensable in the pharmaceutical industry, supporting the development and production of a wide range of biopharmaceuticals, from monoclonal antibodies to gene therapies and cell-based treatments. Its versatility, scalability, and ability to provide precise control over critical parameters make it an essential tool for advancing healthcare and addressing some of the most challenging diseases of our time. As biopharmaceutical research and development continue to evolve, the role of bioprocessing equipment in bringing innovative therapies to patients remains paramount.

Essential Cleanroom Equipment: HEPA ULPA HVAC

Cleanroom equipment plays a crucial role in maintaining controlled environments with extremely low levels of airborne particles, dust, contaminants, and microorganisms. These controlled environments, known as cleanrooms, are essential in various industries, including pharmaceuticals, biotechnology, electronics manufacturing, and aerospace. Cleanrooms are classified based on their level of cleanliness, typically categorized by the number of particles per cubic meter at a specified particle size. Cleanroom equipment helps achieve and maintain the desired cleanliness levels. Here are some common types of cleanroom equipment:

  1. Air Handling Systems:
    • High-Efficiency Particulate Air (HEPA) Filters: HEPA filters remove airborne particles, bacteria, and viruses, ensuring clean air circulation.
    • Ultra-Low Penetration Air (ULPA) Filters: ULPA filters provide even higher filtration efficiency than HEPA filters, removing smaller particles.
  2. HVAC (Heating, Ventilation, and Air Conditioning) Systems:
    • Air Showers: Entryway chambers equipped with high-velocity air jets to remove particles from personnel and equipment before entering the cleanroom.
    • Laminar Flow Hoods: Horizontal or vertical flow hoods that provide a continuous stream of clean air to maintain a sterile environment for processes or equipment.
  3. Cleanroom Apparel:
    • Cleanroom Garments: Specialized suits, gowns, gloves, and shoe covers made from low-particulate materials to prevent contamination from personnel.
    • Facial Masks and Hoods: To cover the face and head, reducing the risk of contaminants from skin and hair.
  4. Furniture and Workstations:
    • Stainless Steel Tables and Benches: Easy-to-clean surfaces for working with sterile materials.
    • Cleanroom Chairs: Designed to minimize particle generation and facilitate easy cleaning.
  5. Gowning and De-Gowning Equipment:
    • Gowning Benches and Racks: Used for donning and doffing cleanroom apparel while maintaining a clean environment.
    • Gowning Room Accessories: Including mirrors, dispensers for gloves, and garment storage.
  6. Cleanroom Lighting:
    • LED Cleanroom Lights: Designed to minimize particulate generation, generate less heat, and provide uniform illumination.
  7. Particle Counters and Monitoring Equipment:
    • Particle Counters: Measure the concentration of airborne particles to ensure compliance with cleanliness standards.
    • Environmental Monitoring Systems: Monitor temperature, humidity, and other environmental parameters.
  8. Cleanroom Cleaning Supplies:
    • Mops and Wipers: Made from materials that won’t shed particles.
    • Cleaning Solutions: Specialized solutions for cleanroom surfaces.
  9. Pass-Through Chambers:
    • Material Pass-Through Chambers: Allow the transfer of materials and supplies into and out of the cleanroom without contaminating the environment.
  • Static Control Devices:
    • Static Ionizers: Neutralize static charges that can attract and trap particles on surfaces.
  • Wall Panels and Ceilings:
    • Cleanroom Wall Panels and Ceilings: Designed to be easy to clean, non-shedding, and provide an airtight seal.
  • Cleanroom Curtains and Strip Doors: Used to partition cleanroom spaces while maintaining cleanliness levels.
  • Fire Suppression Systems: Specialized fire suppression systems designed for cleanrooms to minimize contamination risks.
  • Emergency Shower and Eyewash Stations: Safety equipment for personnel handling hazardous materials in cleanrooms.
  • Sound and Vibration Control Equipment: Minimizes noise and vibrations that can disrupt sensitive processes.
  • Security Systems: Access control systems to ensure that only authorized personnel enter the cleanroom.

Cleanroom equipment selection and design depend on the specific cleanliness requirements, industry standards, and the processes carried out within the cleanroom. Proper maintenance and regular validation of cleanroom equipment are essential to ensure consistent performance and compliance with regulatory requirements.



Tablet Press Machine – Parts Price Manual Manufacturers

Tablet Press

Tablet press machine is used to press dry raw materials into tablet form. Tablet Press are increasingly used in a variety of industries to compress materials like Pharmaceuticals and Life Science Industries, Ayurveda Industries, Silica Industries, Confectionary Industries, Ferrites, Electronics and Defence Industries, Vitamins & Nutraceuticals Industries Salts, Detergents & Metals, API & Bulk Drugs, Food & Confectionary, Nutraceuticals, Ferrites.

Tablet Press Buyers Guide:

Important Specifications of Tablet Press You need to Check Before Buying:

  • Capacity of Torque main motor
  • Water cooling system
  • High Speed
  • Gravity Feeding System
  • Bi-Layer Tablet Attachment
  • Very low Noise level
  • Type of tooling D
  • Rated output (tablets / hour)*
  • Turret speed (rpm)
  • Max. Compaction force-Main (kN)
  • Max. Compaction force-Pre (kN)
  • Biometric Fingerprint lock system
  • Equal Pre & Main compaction of 100 kN
  • Single Tablet Rejection even at highest speed of operation
  • High & Updated Motorised Machine
  • Bi-Layer Tableting with a lot of ease and Separate first Layer Sampling available
  • Zero Clearance,
  • Machine Interlocks with indicating alarms as a Safety Device
  • Compaction Force Control (CFC) system for Auto Weight Control
  • Computer Panel for SCADA
  • 3 – Paddles Force Feeding System
  • Super Thick Upper Guards
  • Sound Reduction & Operator Safety
  • No. of station
  • Max. Tablet diameter (mm)
  • Max. Depth of die fill (mm)
  • Max. Tablet thickness (mm)
  • Upper punch penetration-Main & Pre comp. (mm)
  • Torque direct drive (kW / hp)
  • Power consumption (kW / hp)
  • Power supply
  • Overall dimensions (cm)
  • Net weight (kg)


Tablet Press Machine Parts=Principal components of Tablet Press:

• Hopper
• Fill Tray
• Dies
• Upper Punches and Lower Punches
• Turret
• Upper Tracking and Lower Tracking
• Upper Pressure Cam and Lower Pressure

• The Hopper holds the dry materials that will be compressed.
• The Fill Tray distributes the dry materials into the Die bores and pushes tablets into the Ejection Chute.
• The Dies define the size and shape of the powder.
• The Upper Punches and Lower Punches compress the materials within the Dies.
• The Turret houses the Tooling.
• The Upper Tracking and Lower Tracking guide the Tooling.
• The Upper Pressure Cam and Lower Pressure Cam compress the Upper Punches and Lower Punches to create the tablet.

Parts of Tablet Press

• Dont apply too much force to the powder.
• Dont Try to fill the Die with powder by hand.
• Dont insert Tooling that is too big for the machine.
• Properly mount the machine.
• Dont use powders that could explode under pressure.
• Dont use wet or damp material.
Be aware of risk of entanglement and pinch
point due to moving parts.
• Do not operate in a wet environment or with wet hands due to risk of electrical shock or burn.
• Do not operate if any wires are damaged,pinched, or frayed due to risk of electrical shock or burn.
• Keep fingers away from all moving parts.
• Ensure that machine is secure with antivibration feet on the workspace floor.
• Inspect machine before use.
• Check that nuts and bolts are suitably tightened.
• Use this machine only for its intended use as described in this manual.
• Do not modify the machine in any way.
• Turn off and unplug the machine before conducting cleaning and maintenance.

Tablet Press Machine Price

The price of the tablet press is different with different manufacturers. the price depends also on the purpose of the press designed for. the overall cost varies between 4 lakhs to 50 lakhs.

Pharmaceutical Equipment & Machinery

Pharmaceutical Equipment & Machinery

Pharmaceutical Equipment & Machinery

 When we speak about Pharmaceutical equipment & machinery we speak about endless number of equipment and machinery that are being used on a day to day basis in order to improve the quality of pharmaceutical products and its activities towards treatment.  The field of pharmaceutical requirements is huge and is tied up with different avenues which make it more important for the equipment’s and machinery to work perfectly and produce high quality of products that are error free on a whole.  Today we will be trying shredding few lights on some of the equipment and machinery in use and a little bit about how they are working.

Firstly speaking about the pharmaceutical equipment there are many different types and sizes that are found.  Each of them perform specific tasks and have their own distinct actions as well.  One of such is Homogenizer Equipment which under high pressure reduces the size of the pharmaceutical product particles and provides turbulence, impact and acceleration along with it making them more clinically effective and stable.  Then there is Pharmaceutical Drying Equipment which has the capability of gently drying of pharma ingredients especially crystallization from water by means of filter process or from one or more organic solvents.  Speaking about the pharmaceutical filling equipment, these equipment are specifically used for expediting small and large scale product manufacturing with providing constant output demands.  The equipment works on automated or semi-automated control.  Out of different types of instrument and equipment that are being used one of such equipment that have a very effective part to take place is Powder filling equipment.  These equipment are used to fill the pharmaceutical powder products.  The equipment works automatically and helps in the production.  There is the Auger filling machine as well which also works in the same way as Powder filling equipment.  There are different other equipment like spray drying accessories, syringe filling equipment, Vial filling equipment, pharmaceutical checkweighers, pharmaceutical extrusion equipment which have their own functionalities and working procedures.

Now speaking about Pharmaceutical machinery, the use and application of them in case of pharmaceutical products does have a high significance.  There are different types of machinery that are into use namely, Vibro sifter, Tablet Press, tableting machine, Rapid mixer granulator, Mass mixer, multi mill, coating pan, V blender, tablet making machines, tablet coating machines, sigma mixer and the list is endless.  Now, where tablet press, a specific machine that is used for compressing powder into tablet and giving it a specific form and shape, Pharmaceutical Vibro sifter is used for separating different materials based on the size of their particle and use.  The tableting machine is another very important machinery that is used in the pharmaceutical production houses.  This device is used for making tablets for consumption.  Rapid mixer granulator is another important machine that is used for formation of granules by the process of rising, tumbling and whirling motion of material.  The drying machine is done by adding up all the ingredients into the RMG.  Mass mixer is used for mixing of ingredients whereas multi mill, a self contained portable unit is used for shredding, high speed granulating, mixing, pulversing and chopping purposes.  It has multifunctional working capabilities and one of the most prime machinery used in pharmaceutical production houses.

Pharmaceutical equipment refers to the various tools, machines, devices, and systems used in the pharmaceutical industry for the development, production, packaging, and quality control of pharmaceutical products. These products include drugs, vaccines, biologics, and other medicinal compounds. Pharmaceutical equipment plays a crucial role in ensuring the safety, efficacy, and quality of pharmaceutical products. Here are some key aspects of pharmaceutical equipment:

Manufacturing Equipment:

This category includes machines and systems used for the actual production of pharmaceuticals. Some examples include:

Mixers and Blenders:

Used for mixing and blending powders, granules, and other ingredients to create uniform drug formulations.

Detailed Mixers and Blenders in Pharmaceutical Industry is in this link

Tablet Presses:

Used to compress powders into tablets or pills.

Read about Tablet Press in Detail

Go through Tablet Making Machine India – Cost Price Manual

Capsule Filling Machines:

Used to fill empty capsules with pharmaceutical formulations.

Know about Capsule Filling machines in detail


Used to granulate and size-reduce materials.

Coating Machines:

Applied for coating tablets, pills, or capsules to control release and protect the drug.

Quality Control Equipment:

These tools are essential for ensuring the quality and safety of pharmaceutical products. Examples include:

High-Performance Liquid Chromatography (HPLC):

Used to analyze the chemical composition and purity of drugs.
Mass Spectrometers:

Identify and quantify chemical compounds in pharmaceuticals.


Used for the visual inspection of pharmaceutical products.

Measure the absorbance or emission of light, often used in drug analysis.
Packaging Equipment:

Pharmaceutical products need secure and sterile packaging to protect them from contamination and maintain their integrity. Equipment includes:

Blister Packaging Machines:

Used for packaging tablets and capsules in individual blister packs.

Labeling Machines:

Apply labels with product information to packaging.

Capping Machines:

Seal containers with caps or closures.

Ampoule Filling and Sealing Machines:

Used for filling and sealing ampoules containing liquid medications.

Sterilization Equipment:

Ensures that pharmaceutical products are free from harmful microorganisms. Common methods include autoclaves, dry heat ovens, and gamma radiation.

Material Handling Equipment:

Includes conveyors, lifts, and other machinery used to transport materials within the manufacturing facility.

Laboratory Equipment:

Essential for research and development in the pharmaceutical industry, including items like analytical balances, incubators, and centrifuges.

Bioprocessing Equipment:

Used in the production of biopharmaceuticals, such as bioreactors for cell culture and filtration systems.

Click here to read more on Bioprocessing Equipment

Cleaning Room Equipment

These facilities require specialized equipment to maintain strict cleanliness and control environmental conditions.

Automation and Robotics: Increasingly, pharmaceutical manufacturing processes are becoming automated and robotic to improve precision, reduce human error, and increase efficiency.

Read in detail – Cleanroom Equipment

Regulatory Compliance:

All pharmaceutical equipment must meet strict regulatory standards, such as Good Manufacturing Practices (GMP) and FDA regulations in the United States.

Pharmaceutical equipment manufacturers and suppliers must adhere to stringent quality control measures to ensure that the equipment they produce meets the highest standards of safety, accuracy, and reliability. This is crucial to maintain the integrity of pharmaceutical products and protect public health.

On conclusion it can be easily said that these machinery and equipment are an integral part of pharmaceutical production and without their use things would have been something very much different and difficult to handle.  These products cost very highly due to the extreme capabilities they possesses and thus needs proper guidance when handling.


Preliminary Hazard Analysis (PHA) Determine Equipment Re-qualification Frequency

Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

An Introduction to Equipment Qualification

The pharmaceutical industry induces full of experiments and it often requires conducting batch reactions using toxic or flammable materials. In many cases, complex chemical reactions are carried out with significant energy release. Such exothermic reactions processing can cause fire, explosion or runaway reaction hazards and these are quite life threatening for personnel and facilities. Equipment qualification is a critical step in overall process validation (PV), typically referred to as Stage 2A of the PV life cycle. It is outlined in many regulation and guidelines, including the FDA’s 2011 Process Validation Guidance and Annex 15 of the EU GMP, among others.

While handling the Equipment, one is likely to face the ambiguity of how often to do a given task or activity using them. It is necessary for the equipment to be periodically re-qualified if there is a performance dip with consistent working to ensure the quality of products. Here the focus is on the re-qualification decision-making framework based on the use of the preliminary hazard analysis (PHA), a tool used in quality risk management.

Preliminary Hazard Analysis (PHA) Utility to Determine Equipment and Instrument Re-qualification Frequency

Prior to use in production or quality control testing all new equipment should require passing through all stages of qualification such as

  • Design qualification (DQ)
  • Installation qualification (IQ)
  • Operational qualification (OQ)
  • Performance qualification (PQ)

A robust equipment qualification program is appropriate based on the uses and risks of the equipment. The activities of each of these qualification steps should be well documented, to provide evidence that the equipment is fit for its intended purpose, and those records should be available for review by request.

Stages of equipment and instrument qualification

Figure 1: Stages of equipment and instrument qualification

In the figure above, if we follow the illustration we see that once the equipment has been initially qualified, the qualification program should speak to the periodic re-qualification of equipment. It is a part of implementing any changes through a defined change control process impacting the qualified state of the equipment. Based on the criticality of the equipment used in production or on the quality control testing of products the extent of the re-qualification should be done.  Documentation of the periodic review of pertinent data is indispensable to confirm that a process/method/system continues to consistently produce a result meeting predetermined acceptance criteria.


Two primary principles of quality risk management in the pharmaceutical industry are:

  • The risk evaluation of quality should be based on scientific knowledge and concern about the protection of the personnel and facilities.
  • The quality risk management process should be commensurate with the level of risk with respect to the level of effort, formality, and documentation.

ICH Q9 on Preliminary Hazard Analysis (PHA)

As continuing to the question of “When or at what frequency should the periodic review is performed?”  How should one structure the program to help the user determine when to perform the review? What guidelines to follow to create this aspect of the qualification program?

The answer to these is to perform the ICH Q9 (Quality Risk Management) – the risk management tool PHA. According to ICH Q9, the definition of PHA is that it is a tool to analyse hazardous situations and events that might cause harm, to estimate probable hazards in occurrence for a given activity, facility, product or system based on applying prior experience or knowledge of a hazard or failure to identify future hazards.

The tool consists of the following components:

  • identification of the possibilities that the risk event happens
  • qualitative evaluation of the extent of possible injury or damage to health as an outcome
  • using a combination of severity and likelihood of occurrence, relative ranking of the hazard is given
  • the detection of the possible remedial measures

Figure 2 denotes the PHA worksheet. If we can build a worksheet to organize the analysis and assist with the facilitation of the activities, the PHA tool could essentially address all the review of the parameters, as well as correlate the risk priority ranking to a periodic review frequency for the subject equipment.

It requires team expertise in the quality risk management process, how to use the PHA tool, scoring criteria, and key definitions. It generally consists of equipment owners, process owners, and quality assurance to perform the analysis possessing a strong understanding of the whole hazard analysis. The inputs of each column to the worksheet are directed and provided by a two-step triage approach using risk blocks scored against criteria as high, medium, and low rankings as in Tables 1, 2, and 3.

Figure 2: PHA worksheet example



 PHA work sheet example



Table 1: Severity Rankings

Severity Rankings

 Table 2: Probability (Occurrence) Rankings

Probability (Occurrence) Rankings

 Table 3: Detectability Rankings

Figure 3: Risk class determination

The preliminary risk class based on severity and probability (or occurrence) was first determined as in Figure 3.

Risk priority ranking

Figure 4: Risk priority ranking

Risk priority ranking

Table 4: Example of Periodic Review Frequency

Further the hazard parameters are evaluated against detect-ability, resulting in a risk priority ranking (Figure 4). It correlates to the periodic review frequency for the subject equipment (Table 4). Once the worksheet is completed with input from team members, the periodic review frequencies should be reviewed and agreed to by all. The following PHA worksheet (Figure 5) provides an example of a completed analysis activity.

Figure 5: PHA worksheet example — completed analysis activity


PHA worksheet example — completed analysis activity
PHA worksheet example — completed analysis activity

Inferences drawn about how this method of hazard analysis can be beneficial

  • The PHA tool enables to build a usable worksheet allowing all members of the team to participate in the risk analysis activity to provide subject matter expertise, voice concerns, and promote issues for further discussion.
  • Additionally, by facilitating the team meetings, time schedules were managed and those issues that were a challenge were tabled and discussed offline.
  • At the end of each completed worksheet, team members provide feedback regarding the risk analysis activity noting the efficient use of time, effective use of risk management tools, and delivery of risk priority rankings for subject equipment in correlation with the periodicity frequency.
  • Therefore, using a risk management tool such as PHA, a periodic review frequency can be identified and applied to qualified equipment. This enables a timely recheck of the equipment by means of pertinent data like manufacturing performance trend data, change history, and/or deviation history and that in turn would help in assuring consistent production results meeting the predetermined acceptance criteria.

Formulation Equipment List – Pharmaceutical Formulation Machinery PDF

Formulation Equipment List - Pharmaceutical Formulation Machinery PDF

In pharmaceuticals, formulation (or dosage form) refers to the creation of a structure such as a capsule, a pill, tablet, or an emulsion, prepared according to a specific procedure or “formula”. Competently designed formulations for particular applications are safer, more effective, and more economical than any of their components used singly. There are a range of automated and semi-automated machines and equipment that can assist in the highest quality formulation of pharmaceuticals.

The pharmaceutical industry has the most precise requirements and manufacturing guidelines in terms of quality. As a result, it is critical that pharmaceutical manufacturing equipment comply with good manufacturing practice (GMP). Pharmaceutical manufacturing equipment includes a wide variety of equipment, such as capsule filling machines, x-ray inspection systems, and spray drying accessories. In order to ensure precise manufacturing and formulation development, almost every process can be automated. As a result, there is a piece of pharmaceutical manufacturing equipment involved in every step. 

PDF Formulation Equipment List 

Pharmaceutical Formulation Machinery

  • Economic tablet press
  • Single rotary tablet press
  • Laboratory capsule filler for liquid solutions
  • Automatic capsule filler for liquid solutions
  • Automatic laboratory capsule filler
  • Contained capsule filler
  • High-yield capsule filler
  • Automatic tablet coater for lab scale
  • Tablet auto coater for lab scale
  • Microencapsulation system for your drug delivery system
  • Waste minimization weight sorter for tablets & capsules
  • High capacity weight sorter for tablets & capsules
  • Major Formulation Equipment
  • Homogenizer
  • Filler
  • Vector FLM-1 and FLM-3
  • fluid bed processors
  • High Shear Granulator 
  • Planetary Mixer
  • High shear granulator/blender 
  • V blenders: 
  • Single station tablet press
  • Instrumented sixteen station tablet press (“B” Tooling)
  • Benchtop encapsulation machines (2 pc. Hard-shell)
  • Various semiautomatic compression and encapsulation machines
  • Various granulation and compounding equipment
  • Capsule Sealer & Capsule Printer
  • Perforated coating pans (15″, 19″, 24″ & 36″)
  • Dome extruder
  • spheronizer
  • Comil
  • Wurster columns 
  • Conventional coating pan
  • Formulation Equipment List - Pharmaceutical Formulation Machinery PDF

Today’s technology has much improved with the advancement of time.  Science has provided us with different ways in order to motivate our life and get the best out of it.  A revolution has also taken place in terms of manufacturing and processing machinery as well.  Over the last decade things seems to have change drastically and has provides us with a new horizon of opportunities that we can boost with and help our life grow bigger and better over the coming days.  Manufacturing and processing machinery today has greatly changed over the course of time and most have touch different avenues and left a mark for itself to carry on with.  Today we are going to discussed about some of the formulation and processing machinery and next articles we see how it has changed human life.

List of Medical Laboratory Equipment | Lab Supplies | Clinical Pharma Lab Devices

List of Medical Laboratory Equipment lab supplies instruments used clinical and pharma lab

In this article we deal with the list of Medical Laboratory Equipment and all lab supplies and Instruments.  Clinical  Laboratory Devices are also included in the list. Pharmaceutical equipment always play a vital part in production of the pharmaceutical products.  There are wide range of products that are involved with this process from big to small, light to heavy, semi-automated to fully automated, metal to steel and of different shapes and sizes.  Today we try to list up some of the most important of the pharmaceutical equipment that are generally used in the production unit.

List of Medical Laboratory Equipment

The list is as follows below:

List of Medical Laboratory Equipment lab supplies instruments used clinical and pharma lab

  • Blood Pressure Systems/Blood Pressure Monitor
  • Capnograph/Capnography Monitor
  • Lab Animal Exercise / Walking System
  • Laboratory Animal Anaesthesia System
  • Physiological Monitor
  • Cryogenic Shippers / Cryoshipper
  • Laboratory Refrigerator Freezer
  • Liquid Nitrogen Canister / Liquid Nitrogen Dewar
  • Liquid Nitrogen Freezer / LN2 Freezers
  • Minus 20 freezer (-20C to -40C Freezers)
  • Minus 80 Freezer (-86 Freezer)
  • Plasma Freezer / Blood Bank Freezer
  • Tissue Freezer
  • Ultra Low Temperature Freezer (ULT Freezers)
  • Laboratory Animal Monitoring
  • Forensic Workstation / Forensic Hood
  • Laboratory Freeze Dryer
  • Laboratory Hoods
  • Cage Changing Hoods
  • Cell Processing Work Station
  • Glove Boxes
  • IVF Workstation
  • Laboratory Fume Hoods
  • Laminar Flow Hoods / Biological Safety Cabinets
  • PCR Workstation / PCR Cabinet
  • Reverse Flow Workstations
  • Laboratory Incubators
  • CO2 Incubator / Cell Culture Incubator
  • Dual Polarization Interferometer
  • Quartz Crystal Microbalance (QCM)
  • Surface Plasmon Resonance Imaging (SPR Imaging)
  • Blood Chemistry Analyzer / Blood Analyzers
  • Albumin Analyzers (Albumin Testing)
  • Automated Blood Gas Systems
  • Automatic Biochemistry Analyzer / Automated Biochemical Analyzer
  • Blood Bank Automation System / Automated Blood Bank System
  • Blood Gas Analyzers
  • Blood Lactate Analyzer / Blood Lactate Testing Equipment
  • Chemistry Analyzer / Clinical Chemistry Analyzers
  • External Quality Assessment (EQA)
  • HbA1c Analyzer / Haemoglobin Analyzer
  • Haematology Analyzers
  • Haemostasis Analyzer
  • Immunoassay Analyzer
  • Immunoassay System
  • Immunochemistry Analyzer
  • Laboratory Blood Glucose Analyzers
  • Cell Counters / Colony Counters
  • Automated Cell Counter
  • Bacterial Colony Counters
  • Colony Counting Apparatus
  • Disintegration Tester / Disintegration Apparatus
  • Dissolution Apparatus / Dissolution Tester
  • Dissolution Sampler / Dissolution Sampling System
  • Dissolved CO2 Meter / Dissolved Carbon Dioxide Analyzer
  • Cell Disruptor
  • Cell Harvesting System
  • Off-gel Fractionators/ Off-gel Electrophoresis System
  • UV Trans-illuminator
  • CO2 Transmitter / Carbon Dioxide Transmitter
  • Colony Picker
  • ADME-Tox Screening System
  • Amino Acid Analysis System / Amino Acid Analysis Instruments
  • Automated Hit Picking Systems
  • Automated Proteomics Workcell
  • Bio molecular Interaction Analysis
  • Automated Bio molecular Interaction Analyzer
  • Electrophoresis Analysis
  • Capillary Electrophoresis Instrument
  • Digital Gel Photography System / Gel Image Capture System
  • Electrophoresis Power Supply
  • Gel Electrophoresis Instrument
  • Flow Cytometry
  • Automated Flow Cytometry System
  • Flow Cytometer
  • Friability Tester / Friability Test Apparatus
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • Gas Chromatography Equipment
  • Gas Chromatograph / GC System (GC Instruments)
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • GC / GC MS Software
  • GC Auto-sampler / GC Headspace Auto-sampler
  • GC Fraction Collector
  • GC Gas Regulators / High Purity Gas Regulator
  • Multidimensional Gas Chromatography (MDGC / GCxGC)
  • Portable GC MS
  • Glass Bead Autoclave
  • Glass Bead Sterilization / Laboratory Glass Bead Sterilizer
  • Hyper-spectral Image Analysis
  • Chemical Imaging Systems (NIR / Raman)
  • Hyper-spectral Camera / Hyper-spectral Imaging Systems
  • Immuno-blotting Equipment
  • Blot Strip Cutter
  • Cryogenic Refrigerator / Cryofreezer
  • Animal Pulse Oximeters
  • Animal Temperature Probe
  • Animal Ventilator
  • Animal Warmers
  • Cryogenic Refrigerator
  • Animal Pulse Oximeters

Tablet Making Machine India – Cost Price Manual

Tablet Making Machine

In today’s date “tablets” h0old an essential part of our life.  Most of us consume tablets everyday be it a teenager, middle aged or an old man.  Now consumption of tablets has become a part of our life for most of us if not all.  Looking back at the process of making tablets in the Industry, it is a typical process and passes through certain phases before it is completely done and sealed pack for selling.  Today we will be hereby discussing how tablets making machine is helping to make tablets in short and a precise way.

Tablet Making Machine India – Cost Price Manual

The process

The tablet making machine is generally known as the Tablet Press and consists of two different types mainly.  One is known as the single-punch and another is called the rotary tablet presses.  The punches and dies used for making tablets come in different variety of sizes, shapes, designs and can be easily customized according to need and generally is manufactured with manufacturer codes and scoring lines which makes it more easier for the user to break the tablet at once.  Now depending on the size, shape, material and configuration of the press, the machine (press) can produce from around 250,000 to over 1,000,000 tablets an hour on a general basis as per stats obtained from various production houses.  Now speaking about its mechanism, tablet presses work in a very high speed and takes the form of a rotating turret.  It simply holds number of punches as customized before production.  Once it starts to rotate around the turret, the punches come close in contact with the cams in use and control the punches in a vertical position for the tablets to get manufactured.

The tablet press that we are speaking of here has a simple mechanism to work with.  The main objective of the machine or device is to compresses powder into tablets which comes out in a uniform manner in terms of shape, size and weight as per the requirement of the production house.  The press has got a high potential and generally used to manufacture tablets of different types in conjunction to the variety of materials used.  This can include illicit drugs, pharmaceuticals, cleaning products and cosmetics as well.  The granulated material in order to be given a proper shape into a tablet is firstly metered into a cavity form.  This is done by the use of two punches and a die.  Once this is done, the punches are pressed together with great force.  This in return fuses the materials together giving a shape of a tablet.  For most of the tablet press machines the most integral part of it remains the same ie.  Hopper, Die, Punches, Cam track and feeding mechanism.

Tablet making machine cost manual price

Different types of machine

Now speaking about tablet press and its actions, it is has been found that this tablet making machine comes in two different variants.  One is called the single station or eccentric press and another is the multiple station or popularly known as the rotary tablet press.  The Single station is relatively compact in nature to that of the multiple one and is basically easier to operate among the two in comparison.  It is used to produce chewable tablets, Effervescent and other compressed tablets.  Whereas speaking about the multiple station, its setting up is much more streamlined and can be fined tuned for more customization than that of the two with much higher production rate and obviously the capability of it is immense when compared.  The machine has capability of ejecting, filling and removal of the tablet as well after compression procedure.