Contents of the powerpoint on Vaccine adjuvants include:
CONTENTS
INTRODUCTION
MECHANISMS OF ADJUVANT ACTION
PROPERTIES OF IDEAL ADJUVANT
TYPES OF ADJUVANTS
Aluminum-containing adjuvants
MF59:a oil-in-water emulsion
Freund’s adjuvant
Microorganism – derived adjuvants
Iscoms
Liposomes
Poly(lactide-co-glycolide) microparticles
Nucleic acid – based adjuvants
Mucosal adjuvants
Cytokines
USES OF ADJUVANTS
SAFETY EVALUATION
CONCLUSION
REFERENCES
INTRODUCTION
A vaccine is a biological preparation that improves immunity to a particular disease.

A vaccine may contain one or more of the following

Organisms inactivated by chemical or physical means whilst retaining adequate immunogenic properties;

living organisms that are naturally avirulent or that have been treated to attenuate their virulence whilst retaining adequate immunogenic properties;

antigens extracted from or secreted by the infectious agent ;

plasmid DNA;

antigens produced by chemical synthesis in vitro.

Vaccine adjuvants:

A vaccine adjuvant is a component that potentiates the immune response to an antigen and/or modulates it towards the desired immune response.

In the traditional vaccines impurities or other components of organisms act as adjuvants,
For example diphtheria-tetanus- pertussis (DTP) vaccine contains two potent adjuvants from whole cell pertussis vaccine (LPS and PT), whole cell typhoid and cholera vaccines have potent adjuvants (LPS and cholera toxin).

Therefore, purified, synthetic vaccines require potent adjuvants.

Download the powerpoint by liking us on Facebook
[like-gate][/like-gate]

[button url=”http://pharmawiki.in/?attachment_id=3549″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PPT here[/button]

You can also download the PDF onVaccine adjuvants by clicking here
[button url=”http://pharmawiki.in/?attachment_id=3620″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PDF here[/button]

Contents of the powerpoint on Theories and mechanisms of dissolution testing include:
OUT LINE
Definitions
Theories of Dissolution
Mechanisms of drug release
Wagner theory
Zero order release
First order release
Hixon -Crowel model
Higuchi model
Peppas model
Weibull model
Conclusion

Definitions:
Dissolution:
Dissolution is defined as a process in which a solid substance solubilizes in a given solvent i.e. mass transfer from solid surface to the liquid phase.

Dissolution rate:
Dissolution rate is defined as the amount of solute dissolved in a given solvent under standard conditions of temperature, pH, solvent composition and constant solid surface area.
It is a dynamic process
The rate of dissolution of drug substance is determined by the rate at which solvent-solute forces of attraction overcome the cohesive forces present in solid

Download the powerpoint by liking us on Facebook
[like-gate][/like-gate]

[button url=”http://pharmawiki.in/?attachment_id=3548″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PPT here[/button]

You can also download the PDF onTheories and mechanisms of dissolution testing by clicking here
[button url=”http://pharmawiki.in/?attachment_id=3548″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PDF here[/button]

Contents of the powerpoint on Tablets aqeuos film coating include:
CONTENTS
INTRODUCTION
AQUEOUS FILM COATING OF DOSAGE FORM
Film formation mechanism
Film formers
Plasticizers and colours
PROCESS PARAMETERS
HOW THE COATING PROCESS WORKS
COATING EQUIPMENTS
COATING DEFECTS
SOLVENT FILM COATING

COATING:
IT is the application of coating composition on to the moving bed of tablets with concurrent use of heated air to facilitate evaporation of the solvent.

Formation of films from aqueous polymeric dispersions
This requires the coalescence of polymer particles into a continuous film.

This process involves:
Rapid evaporation of water, causing the particles of dispersed polymer to be brought into close contact with one polymer.
Development of pressures (associated with capillary forces within the structure) that overcome repulsive forces between particles and cause deformation of the polymer particles.
Gradual coalescence of the polymer particles as a result of viscous flow and movement of polymer molecules across the interfaces between particles.

Aqueous polymeric dispersions must be processed at temperatures in excess of the
glass-transition temperature of the polymer.

Download the powerpoint by liking us on Facebook
[like-gate][/like-gate]

[button url=”http://pharmawiki.in/?attachment_id=3547″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PPT here[/button]

You can also download the PDF onTablets aqeuos film coating by clicking here
[button url=”http://pharmawiki.in/?attachment_id=3547″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PDF here[/button]

Contents of the powerpoint on Plasma membrane – physiology structure and role in drug absorption include:
Content
Introduction
Physiology of Plasma membrane.
Structure,
composition,
functions.
Transport across cell membrane.

Conclusion
References

Plasma membrane structure
Definition:
The Plasma membrane is a thin bi- layered structure which surrounds each cell, consists of lipids (phospholipids 75%, cholesterol 20%,glycolipids 5%), proteins (partially or completely embedded), carbohydrates etc.,

~6-10 nm thick.

Plasma membrane is asymmetrical

The fluid mosaic model describes the plasma membrane as a flexible boundary of a cell. The phospholipids move within the membrane.

FLUID- because individual phospholipids and proteins can move around freely within the layer, like it’s a liquid.

MOSAIC- because of the pattern produced by the scattered protein molecules when the membrane is viewed from above.

Plasma Membrane
Phospholipids
Phospholipids are lipids with a phosphate attached to them.

The phospholipids are very flexible and behave similar to a fluid.

The lipids in the plasma membrane can be saturated or unsaturated, the more saturated lipids in a membrane the more rigid the plasma membrane is. The more unsaturated lipids, the more flexible the membrane is.

The phospholipids have a water soluble head, and water insoluble lipid tails.

Other lipids in plasma membrane
GLYCOLIPIDS: Phospholipid molecule attached with a carbohydrate chain straight or branched to its hydrophilic head.
CHOLESTEROL: lipid found in animal plasma membranes which reduces the permeability to most biological molecules.
it regulates membrane fluidity over the range of physiological temperatures.
cholesterol also functions in intracellular transport, cell signaling and nerve conduction.
cholesterol has also been implicated in cell signaling processes, assisting in the formation of lipid rafts in the plasma membrane.
In many neurons a myelin sheath, rich in cholesterol since it is derived from compacted layers of Schwann cell membrane, provides insulation for more efficient conduction of impulses.
Cholesterol present between the fatty acids chains, binds with OH side to the phosphate of lipid by H-bonding.

Download the powerpoint by liking us on Facebook
[like-gate][/like-gate]

[button url=”http://pharmawiki.in/?attachment_id=3546″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PPT here[/button]

You can also download the PDF onPlasma membrane – physiology structure and role in drug absorption by clicking here
[button url=”http://pharmawiki.in/?attachment_id=3529″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PDF here[/button]

Contents of the powerpoint on Pharmacokinetics pharmacodynamics of controlled release systems include:

Introduction

Pharmacokinetic models

Pharmacodynamic models

Conclusion

References

Controlled release:
The term controlled release is associated with therapeutic agents that may be automatically delivered at predetermined rates over long period of time.

The main Goals are :
To reduce the frequency of dosing
To increase the effectiveness of the drug by localizing it
To reduce the dose required
To provide uniform drug delivery

PHARMACOKINETIC MODELS FOR CONTROLLED DRUG DELIVERY
Several models have been proposed to explain the pharmacokinetic behavior of controlled drug delivery systems.

Models of time course profile of absorption and elimination

Loo-Riegelman and Wagner-Nelson model
Model independent pharmacokinetic analysis

Download the powerpoint by liking us on Facebook
[like-gate][/like-gate]

[button url=”http://pharmawiki.in/?attachment_id=3545″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PPT here[/button]

You can also download the PDF onPharmacokinetics pharmacodynamics of controlled release systems by clicking here
[button url=”http://pharmawiki.in/?attachment_id=3528″ style=”glass” background=”#1782f9″ color=”#ffffff” size=”4″ center=”yes” icon=”icon: download”]Download PDF here[/button]