Line Clearance before Operation of Pharmaceutical Manufacturing Area Friabilator PPT PDF

Line Clearance before Operation of Pharmaceutical Manufacturing Area Friabilator PPT PDF

Here we see Line Clearance before Operation of Pharmaceutical Manufacturing Area Friabilator.

What is Friability Testing?

To determine the physical strength of uncoated tablets on exposure to mechanical pressure, Friability test is done. The test can find out the extent of mechanical stress withstandable by the tablets during their manufacturing, distribution and handling processes. Friability testing is an accepted operation across the pharmaceutical industry, and the instrument used to perform this process is called Friabilator or Friability Tester.

Line Clearance before Operation of Pharmaceutical Manufacturing Area Friabilator PPT PDF

PROCEDURE FOR OPERATION AND CLEANING FRIABILATOR

Tablet friability measures the efficiency of friabilator or indicates the formulation suitability along with routine QC functions or measures “dusting”. For a specified period of time, tablets are rotated in a plastic drum. To quantify the amount of surface material that has worn off, a gravimetric determination is made.

The responsibility and the accountability are generally of the Executive Manufacturing, Executive QA and Assistant Manager QA.

 

CLEANING FRIABILATOR

:

  • By pressing the button to remove the knob on the shaft.
  • Pull the outward drum from the shaft carefully. Similarly, remove the inside drum by pulling it outside.
  • By pulling outside remove the detachable disc from both the drums.
  • Clean both the drums with a clean cloth.
  • Remove both the trays. Clean the trays with a clean cloth.
  • After cleaning, put the drums and trays back on its position.

 Line Clearance before Operation of Pharmaceutical Manufacturing Area Friabilator

CORRECT OPERATION:

  • Check cleanliness of the equipment before switching ON.
  • The drum will initialize itself to the loading position; the display will show START.
  • Record the weight of the tablets.

For each tablet weighing up to 0.650 g, take 20 tablets.

For each tablet weighing above 0.650 g, take 10 tablets.

  • Adjust the counts to 100 by pressing the COUNT Key followed by ‘1’, ‘0’, ‘0’ keys. (Count range 1 to 99999).
  • Confirm the reading by pressing ENTER. To see and confirm the number of counts press COUNT Key. Then press RUN/HALT key to start, check the elapsed count. (Test can be performed by adjusting ‘TIME’ similarly as ‘COUNT’.)
  • The test terminates with an audible beep and displaying END and the drum rotates in reverse direction discharging the tablets in the tray.
  • On removing the trays tablets de- dust and weigh the tablets, note down the weight of the tablets.
  • Calculate the percentage loss in the weight by using the formula

(Percentage Loss =Initial Wt – Final Wt/Initial Wt X 100)

 

Conclusion

On completion of the procedure, the samples are moved, wiped-off dust and weighted again. The difference between the weight before and after the test is the Friability and should not exceed 1 %( ideal percentage). In some cases, where the diameter of tablets is greater than 13mm, such tablets are tested on drums at 10° tilt.

Precautions:

  • Do not hold the drums while rotating.
  • After testing, destroy the tablets.

List of Pharmaceutical Equipment’s – Manufacturing Processing Equipment PDF

List of Pharmaceutical Equipment's - Manufacturing Processing Equipment PDF.JPG

List of Pharmaceutical Equipments

 Pharmaceutical Machinery

List of Pharmaceutical Equipment’s – Manufacturing Processing Equipment PDF is here. The growth in advancement and up-gradation of technology in machinery has lead to manufacture all kinds of Pharmaceutical Machinery in India. As low technology offerings have been faster in the initial stage, the Indian machinery today is considered as one of the value-added engineering’s with the integration of new technologies. More than 350 facilities in India’s pharmaceutical-machine manufacturing industry are present. The Indian pharmaceutical machinery industry is currently catering to the segments of tableting and capsulation, powder processing, material handling, R&D equipment and instrumentation, coating, bulk drug plant installation etc. The SME sector facilitates around 800 pharmaceutical machine manufacturing and allied utility service units. Majority of these units undertake the supply of custom-made machineries using the location advantage of buyers and job works. There is tremendous scope for the machinery manufacturers to exploit the potential in the country provide by serving necessary machinery for existing 17,000 pharmaceutical companies. They ensure proper design, ease of user application, simple maintenance and also validation protocol for the new equipment essential for the pharmaceutical companies. The categories varies from pharmaceutical machinery, instrumentation and process control, lab equipment, pharmaceutical research and development (R&D) tools, packaging material and machines, plant design and engineering, pharmaceutical process technology.

Let’s explore the Pharmaceutical Equipment’s

  • ADME-Tox Screening System
  • Amino Acid Analysis System / Amino Acid Analysis Instruments
  • Automated Hit Picking Systems
  • Automated Proteomics Workcell
  • Bio molecular Interaction Analysis
  • Automated Bio molecular Interaction Analyzer
  • Dual Polarization Interferometer
  • Quartz Crystal Microbalance (QCM)
  • Surface Plasmon Resonance Imaging (SPR Imaging)
  • Blood Chemistry Analyzer / Blood Analyzers
  • Albumin Analyzers (Albumin Testing)
  • Automated Blood Gas Systems
  • Automatic Biochemistry Analyzer / Automated Biochemical Analyzer
  • Blood Bank Automation System / Automated Blood Bank System
  • Blood Gas Analyzers
  • Blood Lactate Analyzer / Blood Lactate Testing Equipment
  • Chemistry Analyzer / Clinical Chemistry Analyzers
  • External Quality Assessment (EQA)
  • HbA1c Analyzer / Haemoglobin Analyzer
  • Haematology Analyzers
  • Haemostasis Analyzer
  • Immunoassay Analyzer
  • Immunoassay System
  • Immunochemistry Analyzer
  • Laboratory Blood Glucose Analyzers
  • Cell Counters / Colony Counters
  • Automated Cell Counter
  • Bacterial Colony Counters
  • Colony Counting Apparatus
  • Cell Disruptor
  • Cell Harvesting System
  • CO2 Transmitter / Carbon Dioxide Transmitter
  • Colony Picker
  • Disintegration Tester / Disintegration Apparatus
  • Dissolution Apparatus / Dissolution Tester
  • Dissolution Sampler / Dissolution Sampling System
  • Dissolved CO2 Meter / Dissolved Carbon Dioxide Analyzer
  • Electrophoresis Analysis
  • Capillary Electrophoresis Instrument
  • Digital Gel Photography System / Gel Image Capture System
  • Electrophoresis Power Supply
  • Gel Electrophoresis Instrument
  • Off-gel Fractionators/ Off-gel Electrophoresis System
  • UV Trans-illuminator
  • Flow Cytometry
  • Automated Flow Cytometry System
  • Flow Cytometer
  • Friability Tester / Friability Test Apparatus
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • Gas Chromatography Equipment
  • Gas Chromatograph / GC System (GC Instruments)
  • Gas Chromatograph Mass Spectrometer (GC MS Instrument)
  • GC / GC MS Software
  • GC Auto-sampler / GC Headspace Auto-sampler
  • GC Fraction Collector
  • GC Gas Regulators / High Purity Gas Regulator
  • Multidimensional Gas Chromatography (MDGC / GCxGC)
  • Portable GC MS
  • Glass Bead Autoclave
  • Glass Bead Sterilization / Laboratory Glass Bead Sterilizer
  • Hyper-spectral Image Analysis
  • Chemical Imaging Systems (NIR / Raman)
  • Hyper-spectral Camera / Hyper-spectral Imaging Systems
  • Immuno-blotting Equipment
  • Blot Strip Cutter
  • Inhalation Exposure System / Aerosol Inhalation Chamber
  • Laboratory and Industrial Freezers
  • Cryogenic Refrigerator / Cryofreezer
  • Cryogenic Shippers / Cryoshipper
  • Laboratory Refrigerator Freezer
  • Liquid Nitrogen Canister / Liquid Nitrogen Dewar
  • Liquid Nitrogen Freezer / LN2 Freezers
  • minus 20 freezer (-20C to -40C Freezers)
  • minus 80 Freezer (-86 Freezer)
  • Plasma Freezer / Blood Bank Freezer
  • Tissue Freezer
  • Ultra Low Temperature Freezer (ULT Freezers)
  • Laboratory Animal Monitoring
  • Animal Pulse Oximeters
  • Animal Temperature Probe
  • Animal Ventilator
  • Animal Warmers
  • Blood Pressure Systems / Blood Pressure Monitor
  • Capnograph / Capnography Monitor
  • Lab Animal Exercise / Walking System
  • Laboratory Animal Anaesthesia System
  • Physiological Monitor
  • Laboratory Freeze Dryer
  • Laboratory Hoods
  • Cage Changing Hoods
  • Cell Processing Work Station
  • Forensic Workstation / Forensic Hood
  • Glove Boxes
  • IVF Workstation
  • Laboratory Fume Hoods
  • Laminar Flow Hoods / Biological Safety Cabinets
  • PCR Workstation / PCR Cabinet
  • Reverse Flow Workstations
  • Laboratory Incubators
  • CO2 Incubator / Cell Culture Incubator
  • Dry Bath Incubator / Dry Block Heater
  • Hybridization Incubator
  • Hypoxia Incubator / Hyperoxia Incubators
  • Hypoxic Chamber
  • Incubators and Microbiology Incubators
  • Insect Growth Chamber
  • Laboratory Bioreactor / Cell Culture Bioreactor (Fermentor)
  • Laboratory Test Chambers / Stability Chambers
  • Modular Incubation Chamber (Incubator Chamber)
  • Plant Incubator / Environmental Growth Chambers
  • Radioactivity Containment Incubator
  • Refrigerated Incubator
  • Refrigerated Incubator Shakers
  • Rodent Incubators
  • Roller Bottle Incubator / Roller Bottle Apparatus
  • Shaking Incubator / Incubator Shakers
  • Single Use Bioreactor
  • Vortex Mixer (Incubator)
  • Water Jacketed Incubator
  • Laboratory Pumps
  • Continuous Flow Pump
  • Hazardous Location Pump
  • High Pressure Syringe Pumps
  • Laboratory Liquid Aspiration System
  • Laboratory Peristaltic Pump
  • Laboratory Vacuum Pumps
  • Liquid Pumps
  • Metering Pumps
  • Syringe Infusion Pump / Laboratory Infusion Pump
  • Syringe Pump / Programmable Syringe Pump
  • Laboratory Spray Dryer
  • Laboratory Sterilization Equipment
  • Agar sterilizer / Media Sterilizer
  • Autoclave Sterilizer / Laboratory Autoclaves
  • Cleaning-In-Place (CIP) System / Sterilization-In-Place (SIP) Systems
  • Dry Heat Sterilizer / Dry Heat Oven
  • Laboratory Steam Sterilizer
  • UV Chamber
  • Liquid Chromatography Mass Spectrometer (LC MS Instrument)
  • Liquid Handling Equipment
  • Automated Petri Dish Filler / Agar Plate Pourer
  • Automated Pharmaceutical Formulation Systems
  • Automated Solid Phase Extraction System (SPE System)
  • Automated TLC Spotting System (TLC Spotter)
  • Automated Vial Filling Machine
  • Laboratory Burette / Bottle-top Burettes
  • Laboratory Dispensers / Lab Dispenser
  • Laboratory Liquid Aspiration System
  • Liquid Handling Robotics (Automated Systems)
  • Dispenser / Multichannel Pipetting System (Automated Pipetting)
  • Stacker /  Handler
  • Washer / ELISA Plate Washer
  • Pipettes / Micropipettes
  • Mass Spectrometers
  • Clinical Mass Spectrometry / Clinical Diagnostics Mass Spectrometer
  • Electro-spray Ionization Quadrupole Mass Spectrometer
  • Inductively Coupled Plasma Mass Spectrometer (ICP MS)
  • Maldi TOF Mass Spectrometer (MALDI TOF MS)
  • Mass Spectrometers (by Ion Source)
  • Mass Spectrometers (by Mass Analyzer)
  • Mass Spectrometers (by Systems)
  • Proton Transfer Reaction Mass Spectrometer (PTR-MS)
  • Thermal Evolved Gas Analyzer / Mass Spectrometer (EGA-MS)
  • Mechanical Micro-dissection System / Piezo Power Micro-dissection Systems (PPMD)
  • Microarray Technology / Microarray Imaging
  • Hybridization Station / Microarray Hybridization
  • Microarray Reader / Microarray Scanner
  • Micro-encapsulator
  • Instrumentation
  • Automated Labeler
  • Automated Seal Piercer
  • Automated Sealer
  • Dried Blood Spot (DBS) Processor
  • ELISA System / ELISA Workstation
  • Fluorescent Plate Reader
  • Integrated Multi-Assay Workstation
  • Manual Sealer
  • Capper
  • Centrifuge
  • Dispenser / Multichannel Pipetting System (Automated Pipetting)
  • Incubator Shaker
  • Reader / Micro-titer Plate Reader
  • Micro-plate Reader Gas Control Module
  • Micro-plate Sealing Film
  • Micro-plate Stacker / Micro-plate Handler
  • Micro-plate Thawing Station
  • Micro-plate Transport System / Automated Micro-plate Mover
  • Micro-plate Washer / ELISA Plate Washer
  • Micro-plates / Microtiter Plate
  • Multimode Micro-plate Reader
  • Nephelometer / Micro-plate Nephelometry Reader
  • Plate Luminometer / Luminescence Reader
  • Tube Luminometer
  • Non-Invasive Carbon Dioxide Sensors
  • Non-Invasive pH Sensors
  • Nucleic Acid Sample Preparation
  • DNA Shearing Sonicator
  • Next Gen Sequencing Library Construction / Fragment Library System
  • Nucleic Acid Purification Instruments
  • Organic Synthesizer / Chemical Synthesizer
  • Oxygen Measurement / Oxygen Analysis
  • Dissolved Oxygen Analyzer / Dissolved Oxygen Monitor
  • Non-Invasive Oxygen Sensors
  • Oxygen Transmitter
  • Portable Dissolved Oxygen Meter
  • Shake Flask Monitoring System / Multidisc Monitoring Systems
  • Particle Analysis / Particle Characterization
  • Automatic Titrator / Auto titration (Autotitrator)
  • Chemisorption Analyzer
  • Magnetic Analyzer (Metallic Iron Analyzer)
  • Particle Analysis / Characterization Accessories
  • Particle Counting (Particle Counter)
  • Particle Imaging Systems (Particle Shape Analysis)
  • Particle Size Measurement / Particle Sizing Systems
  • Physisorption Analysis
  • Porisimeter
  • Surface Energy Analyzer (Inverse Gas Chromatograph)
  • Zeta Potential Analyzer
  • PCR Technology / PCR Systems
  • DNA Thermal Cycler / PCR Instrument
  • Gradient PCR Machine
  • PCR Workstation / PCR Cabinet
  • Real Time PCR Machine (qPCR Machine)
  • pH Transmitter
  • Physiology and Neurology Equipment
  • Brain Slice Chamber
  • Electrophysiology Equipment
  • Portable Laboratory Equipment / Field Testing Equipment
  • Hand Held TDS Meter / Portable TDS Meters
  • Leaf Area Meter / Portable Leaf Area Meters
  • Portable Balances
  • Portable Conductivity Meter (EC Meters)
  • Portable Density Meter / Handheld Density Meter
  • Portable Dissolved Oxygen Meter
  • Portable Fume Extractor / Laboratory Fume Extractors
  • Portable Fume Hood
  • Portable GC MS
  • Portable pH Meter / Hand Held pH Meter
  • Portable Photosynthesis System
  • Portable Raman Spectrometer
  • Portable Refractometer / Handheld Refractometers
  • Portable Spectrometer / Handheld Spectrometer
  • Portable TOC Analyzer
  • Portable Turbidity Meter (Portable Turbidimeter)
  • Portable Viscometer
  • Portable XRF Analyzer / Handheld XRF Analyzer
  • Soil Respiration / Soil CO2 Flux Systems
  • Powder Analysis (Powder Analyzer)
  • Powder Flow Tester / Powder Flow Analyzer
  • Powder Handling Equipment / Powder Dispensing Equipment
  • Automated Pharmaceutical Formulation Systems
  • Automated Powder Handling Systems
  • Laboratory Powder Dispenser / Benchtop Powder Dispensers
  • Powder Dispensing System / Semi-Automated Powder Dispensing Systems
  • Powder Flow Tester / Powder Flow Analyzer
  • Powder Pipette
  • Process Analyzer / Process Analysis
  • At-Line NIR Analyzer
  • Chromatography Process Analyzers
  • In Situ Raman Spectrometer
  • NIR Analysis Software
  • Online NIR Analyzers / Inline NIR Analyzer
  • Proton Transfer Reaction Mass Spectrometer (PTR-MS)
  • Refractometer / Brix Refractometers
  • Abbe Refractometer
  • Automatic Refractometer
  • Clinical Refractometer
  • Digital Refractometers
  • Portable Refractometer / Handheld Refractometers
  • TPN Refractometer / Total Parenteral Nutrition Refractometers
  • Rheometers / Viscometers
  • Capillary Rheometer
  • Cone and Plate Rheometer (Cone Plate Rheometers)
  • Cone and Plate Viscometer (Cone Plate Viscometers)
  • Controlled Stress Rheometer
  • Dynamic Shear Rheometer
  • Falling Ball Viscometer / Falling Sphere Viscometers
  • Krebs Viscometer
  • Portable Viscometer
  • Rotational Rheometer
  • Rotational Viscometer / Rotary Viscometers
  • Viscometer / Digital Viscometer
  • Viscometer / Rheometer Accessories
  • Shake Flask Monitoring System / Multidish Monitoring Systems
  • Solid Phase Extraction Equipment (SPE Equipment)
  • Automated Solid Phase Extraction System (SPE System)
  • Extraction System Controller
  • Solvent Recovery System / Bench Top Solvent Recovery Systems
  • SPE Cartridge / Solid Phase Extraction Cartridges
  • SPE HPLC Systems
  • SPE Manifold
  • SPME (Solid Phase Micro-extraction) Syringe
  • Vacuum Evaporator / Vortex Evaporator
  • Transfection Technology
  • Micro-porator / Microporation
  • Ultrasonic Homogenizer / Laboratory Homogenizers (Sonicator)
  • Veterinary Test Kits / Veterinary Diagnostic Kits

Present Scenario

Indian pharmaceutical-machine makers and their Western counterparts increasingly are exploring collaborations and partnerships with each other to innovate or share new technology. Together, they are targeting more price conscious products in developing countries. The number of joint ventures between foreign and Indian machinery manufacturers is a testimony of the Indian machinery industry that can produce international quality at affordable prices by understanding the stringent need of pharmaceutical industry. It is significant to note that compared to the US and Europe, India and China are making machinery which is 10-20 times less expensive. However, German made machines are unbeatable in quality, though the prices are undoubtedly more than India and it is difficult for Indian manufacturers to produce such quality machines presently.

In future, we can estimate the pharmaceutical companies waging an all-out war to gain a competitive leverage by slashing their production costs to increase their bottom line with little or no time to efficiently plan and design their manufacturing processes. This would set the machinery industry to make in-roads in the various markets of the world leading a manufacturing revolution just like the IT industry.

[#PDF PPT] Hot Air Oven Working Principle Sterilization Diagram SOP Uses Temperature

hot air oven working pdf

Hot Air Oven Working Principle Sterilization Labelled Diagram Temperature [ #PDF PPT ] is the main theme of this article. Sterilization and aseptic processing are essential practices for healthcare product manufacture and many healthcare services. The execution of these processes in an appropriate manner is essential for patient safety.

A hot air oven is used to sterilize equipment and materials used in the medical field. A hot air oven is a type of dry heat sterilization. Dry heat sterilization is used on equipment that cannot be wet, and on material that will not melt, catch fire, or change form when exposed to high temperatures. Moist heat sterilization uses water to boil items or steam them to sterilize and does not take as long as dry heat sterilization. Examples of items that are not sterilized in a hot air oven are surgical dressings, rubber items, or plastic material. Items that are sterilized in a hot air oven include:

Glassware (petri dishes, flasks, pipettes, and test tubes)
Powders (starch, zinc oxide, and sulfadiazine)
Materials that contain oils
Metal equipment (scalpels, scissors, and blades)
Glass test tubes can be sterilized using a hot air oven
Glass test tubes can be sterilized using a hot air oven
Hot air ovens use extremely high temperatures over several hours to destroy microorganisms and bacterial spores. The ovens use conduction to sterilize items by heating the outside surfaces of the item, which then absorbs the heat and moves it towards the center of the item.

The commonly-used temperatures and time that hot air ovens need to sterilize materials is 170 degrees Celsius for 30 minutes, 160 degrees Celsius for 60 minutes, and 150 degrees Celsius for 150 minutes.

hot air oven images

Principle of HOT AIR OVEN (Dry heat sterilization) 

Sterilizing by dry heat is accomplished by conduction. The heat is absorbed by the outside surface of the item, then passes towards the centre of the item, layer by layer. The entire item will eventually reach the temperature required for sterilization to take place.

Dry heat does most of the damage by oxidizing molecules. The essential cell constituents are destroyed and the organism dies. The temperature is maintained for almost an hour to kill the most difficult of the resistant spores.

The most common time-temperature relationships for sterilization with hot air sterilizers are

170°C (340°F) for 30 minutes,
160°C (320°F) for 60 minutes, and
150°C (300°F) for 150 minutes or longer depending up the volume.

Hot Air Oven ppt working principle uses diagam ppt

Hot Air Oven Working Principle Sterilization Labelled Diagram PDF ppt

Note: Bacillus atrophaeus spores should be used to monitor the sterilization process for dry heat because they are more resistant to dry heat than the spores of Geobacillus stearothermophilus. The primary lethal process is considered to be oxidation of cell constituents.

working principle of hot air oven

Types of HOT AIR OVEN

the static-air type and
the forced-air type.

There are two types of dry-heat sterilizers:

the static-air type and
the forced-air type.
The static-air type is referred to as the oven-type sterilizer as heating coils in the bottom of the unit cause the hot air to rise inside the chamber via gravity convection. This type of dry-heat sterilizer is much slower in heating, requires longer time to reach sterilizing temperature, and is less uniform in temperature control throughout the chamber than is the forced-air type.

The forced-air or mechanical convection sterilizer is equipped with a motor-driven blower that circulates heated air throughout the chamber at a high velocity, permitting a more rapid transfer of energy from the air to the instruments.

Hot Air Oven Labelled Diagram

hot air oven labelled diagram

Uses of HOT AIR OVEN (dry heat sterilization)

A dry heat cabinet is easy to install and has relatively low operating costs;
It penetrates materials
It is nontoxic and does not harm the environment;
And it is noncorrosive for metal and sharp instruments.
Disadvantages for dry heat sterilization

Time consuming method because of slow rate of heat penetration and microbial killing.
High temperatures are not suitable for most materials.

Working Principle of HOT AIR OVEN

Sterilizing by dry heat is accomplished by conduction. The heat is absorbed by the outside surface of the item, then passes towards the centre of the item, layer by layer. The entire item will eventually reach the temperature required for sterilization to take place.

Dry heat does most of the damage by oxidizing molecules. The essential cell constituents are destroyed and the organism dies. The temperature is maintained for almost an hour to kill the most difficult of the resistant spores.

The most common time-temperature relationships for sterilization with hot air sterilizers are

170°C (340°F) for 30 minutes,
160°C (320°F) for 60 minutes, and
150°C (300°F) for 150 minutes or longer depending up the volume.

Different Types of Hot Air Ovens
There are two types of hot air ovens. One is a forced air hot air oven and the other is a static air hot air oven. The forced air hot air oven is more effective than the static air hot air oven.

The forced air hot air oven works by heating the oven and using a fan to move the hot air around. This helps prevent the hot air from rising to the top of the oven and keeping the cooler air at the bottom. The fan keeps the hot air moving around at a consistent temperature throughout the oven.

The static air hot air oven works by using a heating coil at the bottom of the oven. The heat rises throughout the oven and takes a longer time to reach the desired temperature. Since the heat is not circulated as with a forced air hot air oven the temperature is not consistent throughout the oven.

STANDARD OPERATING PROCEDURE of HOT AIR OVEN

Aim:

To lay down the procedure for operation of Hot Air Oven.

Procedure:

1. Connect the power supply.
2. Switch “ON” the main power supply and instrument mains.
Temperature setting
3. Press SET POINT (x/w) key to set the required temperature. press ↑ to
increase the temperature and ↓ to reduce the temperature
4. The temp. Sensor will maintain the set temp which is indicated by the blinking
of set temp on the display screen.
5. The duration of time can also be adjusted using the time adjustment knob
6. After use,SWITCH OFF the power supply.

Safety & Precautions:

=> Maximum Temp. : 350o
C.
=> Ensure that the Exhaust blower is ON before starting the oven.
=> Ensure the GN2 plant is UP.
=> Ensure that temperature does not shoot higher than the set temperature

Cleaning:

# Wipe the surface, walls, top, bottom and trays of the oven with dry lint free
cloth on daily basis so that there will be no dust particles in the oven.
# Wipe all the parts and outer surface of the Oven with wet lint free cloth
soaked in purified water, on weekly basis and fill the weekly cleaning

Note: Bacillus atrophaeus spores should be used to monitor the sterilization process for dry heat because they are more resistant to dry heat than the spores of Geobacillus stearothermophilus. The primary lethal process is considered to be oxidation of cell constituents.

Hot Air Oven Uses ( Advantages) :

Items that are sterilized in a hot air oven include:

Glassware (petri dishes, flasks, pipettes, and test tubes)
Powders (starch, zinc oxide, and sulfadiazine)
Materials that contain oils
Metal equipment (scalpels, scissors, and blades)
Glass test tubes can be sterilized using a hot air oven
Glass test tubes can be sterilized using a hot air oven
Hot air ovens use extremely high temperatures over several hours to destroy microorganisms and bacterial spores. The ovens use conduction to sterilize items by heating the outside surfaces of the item, which then absorbs the heat and moves it towards the center of the item.

Note:Items that are not sterilized in a hot air oven are surgical dressings, rubber items, or plastic material.

Disadvantages for dry heat sterilization

Time consuming method because of slow rate of heat penetration and microbial killing.
High temperatures are not suitable for most materials.

Incoming Searches:

hot air oven , hotair oven, air oven principle, principle of hot air oven, hot air oven drawing , hot air oven sterilization , hot air oven uses , labelled diagram of hot air oven , hot air oven diagram , working principle of hot air oven pdf , hot air oven principle pdf, hot air oven temperature , uses of hot air oven , hot air oven temperature , hot air oven working , air oven, hot air oven working principle , hot air oven principle , hot air oven principle , hot air oven temperature and time , hotair oven , principle of hot air oven , principle of hot air oven, hot air oven pdf , hotair oven , hot air oven uses , working principle of hot air oven pdf , hot air oven working , hot air oven principle pdf, hot air oven principle pdf , hot air oven working principle , hot air oven principle pdf , uses of hot air oven , hot air oven images , hot air oven working , hot air oven working , hot air oven working principle , hot air oven working principle , laboratory hot air oven , calibration of hot air oven , validation of hot air oven pdf , hot air oven pdf , laboratory hot air oven diagram , oven working principle, hot air sterilization [#PDF PPT] Hot Air Oven Working Principle Sterilization Diagram SOP Uses Temperature

Tablet Hardness Tester SOP – Calibration Procedure| Standard operating procedure Tablet | Cleaning

monsanto hardness tester procedure Pfizer

Hardness has long been regarded as an important quality characteristic of tablets. Until recently, only two practical types of tablet hardness testers were available to the pharmaceutical industry. A new addition to this field of testing has just been made. An evaluation of the new instrument includes test comparisons against existing tablet hardness test equipment.Pharmaceutical Equipment Standard operating procedure of Tablet Hardness Tester for performance of tablet Hardness Tester of pfizer stokes monsanto strong cobb for quality control is given below.

Tablet Hardness Tester Standard operating procedure Pfizer Monsanto:

1. Scope:

Applicable to determination of weight, diameter, hardness and thickness of a tablet during in process checking.

2 Objective

This standard operating procedure is intended to provide operating instructions and safety information for the  Hardness tester apparatus. This document is intended as a guideline and supplement to proper training that must be provided by qualified personnel before the apparatus is operated. The aim of this document is to ensure that safe work practices have been developed for the apparatus experimental work. This SOP is primarily concerned with the apparatus operating procedure, hazards involved with the apparatus use and safety precautions that must be taken to avoid injuries.

3.RESPONSIBILITIES :

It is the responsibility of designated personnel in Research lab to train staff and students on this procedure and to ensure adherence to this procedure.  It is the responsibility of designated personnel (staff or Student) to follow the instructions of this procedure.

4. REFERENCES

Instruction Manual Tablet Hardness Tester Type:

5. DEFINITIONS Nil

6. PRECAUTIONS

During the test, parts of the body like fingers etc. can be squeezed between the movable test jaw and fixed jaw.
Please put in the samples by tweezers or a similar tool.

To remove remaining tablet debris use the supplied brush.
During breaking the test samples fragments of the samples can spring off. Use only protective glasses

monsanto hardness tester procedure Pfizer

PDF PPT SOP Pharmaceutical Equipment Tablet Hardness Tester Standard operating procedure Pfizer Monsanto:

See the list below for detailed procedures in PDF format. Check all the documents if some thing has misfiled.

Click below

pfizer hardness tester procedure,
monsanto hardness tester mechanism,
monsanto hardness tester procedure,
monsanto hardness tester calibration,
monsanto hardness tester units,
pfizer tablet hardness tester,
strong cobb hardness tester,
stokes monsanto hardness tester parts

monsanto hardness tester mechanism

monsanto hardness tester procedure

monsanto hardness tester units

pfizer hardness tester procedure

pfizer hardness tester

pfizer tablet hardness tester

sop for pfizer hardness tester Friability

sop for pfizer hardness tester sop for tablet hardness tester

tablet hardness tester

Tablet Hardness Tester SOP – Calibration Procedure| Standard operating procedure Tablet | Cleaning
Tablet Hardness Tester SOP – Calibration Procedure| Standard operating procedure Tablet | Cleaning

7.TECHNICAL INFORMATION

Units Conversion List

The following list shows the relationship between the various units that the hardness tester is capable of measuring in: 1 Kilo Pond = 9.807 Newtons 1 Kilo Pond = 1.4 Strong Cobbs 1 Strong Cobb = 0.714 Kilo Ponds 1 Strong Cobb = 7.005 Newtons 1 Newton = 0.102 Kilo Ponds 1 Newton = 0.143 Strong Cobbs 1 Newton = 2.2048 Lbs. 8.2 RS-232 Serial Port The connector for the RS-232 serial port of the hardness tester is a 25 pin male Sub-D connector.

Interface Baud Rate 2400 Parity Even Data Bits 7 Stop Bits 1 Handshake Hardware RTS/CTS

Pin Assignments Pin Signal Description 1 Protective Ground 2 TXD Transmit Data 3 RXD Receive Data 4 RTS Request to Send 5 CTS Clear to Send 6 DSR Data Set Ready 7 GND Signal Ground 20 DTR Data Terminal Ready

 Data Output

All information printed on the built in printer is automatically sent to the serial port. Page 22 Model HT-300/500 Operation Manual Version 3.0

 Data Input

The following is a list of commands that can be used to control the hardness tester via the serial port: Command Function S Start Test – same as pressing START key A Stop Test – same as pressing STOP key P Printer On – turn the printer on N Printer Off – turn the printer off